{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:47:44Z","timestamp":1773078464350,"version":"3.50.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"755","license":[{"start":{"date-parts":[[1988,9,1]],"date-time":"1988-09-01T00:00:00Z","timestamp":589075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 74 year old man with light-chain myeloma developed amyloidosis with macroglossia after 10 years of therapy with alkylating agents. Over a 2-year period his tongue enlarged to persistently protrude from his mouth, inhibit his speech, interfere with normal swallowing and eventually threaten his airway. As a life-saving procedure the tumorous anterior two-thirds of the tongue was resected, with excellent primary healing. Within two weeks the patient\u2019s speech became comprehensible and his ability to eat returned to normal. Although rare in amyloidosis, massive macroglossia may occur and surgical correction is easily achieved.<\/jats:p>","DOI":"10.1136\/pgmj.64.755.696","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"696-698","source":"Crossref","is-referenced-by-count":22,"title":["Massive macroglossia, amyloidosis and myeloma"],"prefix":"10.1093","volume":"64","author":[{"given":"P","family":"Jacobs","sequence":"first","affiliation":[{"name":"The University of Cape Town Leukaemia Centre , Cape , South Africa"},{"name":"Department of Haematology , Cape , South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sellars","sequence":"additional","affiliation":[{"name":"The University of Cape Town Leukaemia Centre , Cape , South Africa"},{"name":"Department of Otolaryngology , Cape , South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H S","family":"King","sequence":"additional","affiliation":[{"name":"The University of Cape Town Leukaemia Centre , Cape , South Africa"},{"name":"Radiotherapy, University of Cape Town and Groote Schuur Hospital, Observatory , Cape , South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1056\/NEJM198006053022305","article-title":"Amyloid deposits and amyloidosis; the beta fibrilosis","volume":"302","author":"Glenner, G.G.","year":"1980","unstructured":"Glenner, G.G. 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Am J Dig Dis 1968, 13: 619.","journal-title":"Am J Dig Dis"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0030-4220(80)90026-2","article-title":"Oral amyloidosis as initial symptom of multiple myeloma: a case report","volume":"49","author":"Flick, W.G.; Lawrence, F.R.","year":"1980","unstructured":"Flick, W.G. & Lawrence, F.R. Oral amyloidosis as initial symptom of multiple myeloma: a case report. Oral Surgery 1980, 49: 18.","journal-title":"Oral Surgery"},{"issue":"10","key":"ref_5","first-page":"98","article-title":"Deposition of amyloid in the gastrointestinal tract","volume":"1969","author":"Gilat, T.; Revach, M.; Sohar, E.","unstructured":"Gilat, T., Revach, M. & Sohar, E. Deposition of amyloid in the gastrointestinal tract. Gut 1969, 10: 98-104.","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00000441-195409000-00012","article-title":"Primary systemic amyloidosis","volume":"228","author":"Matthews, W.H.","year":"1954","unstructured":"Matthews, W.H. Primary systemic amyloidosis. Am J Med Sci 1954, 228: 317.","journal-title":"Am J Med Sci"},{"issue":"1","key":"ref_7","first-page":"3","article-title":"The pathogenesis of amyloidosis","volume":"1964","author":"Osserman, E.F.; Takatsuki, K.; Tallal, N.","unstructured":"Osserman, E.F., Takatsuki, K. & Tallal, N. The pathogenesis of amyloidosis. Sem Hematol 1964, 1: 3.","journal-title":"Sem Hematol"},{"issue":"2","key":"ref_8","first-page":"128","article-title":"Amyloidosis and plasma cell dyscrasias: gastrointestinal involvement","volume":"1986","author":"Carlson, H.C.; Breen, J.F.","unstructured":"Carlson, H.C. & Breen, J.F. Amyloidosis and plasma cell dyscrasias: gastrointestinal involvement. Sem Roentgen 1986, 2: 128.","journal-title":"Sem Roentgen"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/pgmj.63.738.281","article-title":"Surgical complications of amyloid disease","volume":"63","author":"O'Doherty, D.P.; Neoptolemos, J.P.; Bouch, D.C.; Wood, K.F.","year":"1987","unstructured":"O'Doherty, D.P., Neoptolemos, J.P., Bouch, D.C. & Wood, K.F. Surgical complications of amyloid disease. 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