{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:32:13Z","timestamp":1770064333203,"version":"3.49.0"},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"756","license":[{"start":{"date-parts":[[1988,10,1]],"date-time":"1988-10-01T00:00:00Z","timestamp":591667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The principles of management for acute liver failure are: 1. Accurate diagnosis of the type--fulminant, late onset, acute on chronic--and establishment of likely aetiology. 2. Early detection and treatment of complications, particularly metabolic acidosis (early), renal failure, cerebral oedema and infections (late). 3. Optimization of conditions for regeneration by maintenance of normal metabolic milieu (? removal of toxins). 4. Early consideration of an orthotopic liver transplant for poor prognosis group.<\/jats:p>","DOI":"10.1136\/pgmj.64.756.769","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"769-771","source":"Crossref","is-referenced-by-count":1,"title":["Management of acute liver failure"],"prefix":"10.1093","volume":"64","author":[{"given":"R","family":"Williams","sequence":"first","affiliation":[{"name":"Liver Unit, King\u2019s College Hospital , Denmark Hill, London SE5 9RS"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,10,1]]},"reference":[{"key":"ref_1","article-title":"Clinics in Critical Care Medicine -","year":"1986","unstructured":"Clinics in Critical Care Medicine - Liver Failure (Ed. Roger Williams), Churchill Livingstone, Edinburgh, London, 1986."},{"issue":"2","key":"ref_2","article-title":"Seminars in Liver Disease","volume":"6","author":"Berk, Paul D.","year":"1986","unstructured":"Seminars in Liver Disease (Eds. Paul D. Berk and Roger Williams), Vol. 6, No. 2. Thieme-Stratton, New York, 1986."},{"key":"ref_3","first-page":"481","article-title":"Management of acute liver failure","volume":"13","author":"O'Grady, J.G.; Williams, R.","year":"1987","unstructured":"O'Grady, J.G. & Williams, R. Management of acute liver failure. Hospital Update (Emergency Medicine) 1987, 13: 481-493.","journal-title":"Hospital Update (Emergency Medicine)"},{"key":"ref_4","first-page":"1186","article-title":"Controlled trials of charcoal haemoperfusion and prognostic factors","volume-title":"fulminant hepatic failure. Gastroenterology 1988","volume":"94","author":"O'Grady, J.G.; Gimson, A.E.S.; O'Brien, C.J.; Pucknell, A.; Hughes, R.D.; Williams, R.","unstructured":"O'Grady, J.G., Gimson, A.E.S., O'Brien, C.J., Pucknell, A., Hughes, R.D. & Williams, R. Controlled trials of charcoal haemoperfusion and prognostic factors in fulminant hepatic failure. Gastroenterology 1988, 94: 1186-1192."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/756\/769\/50079025\/postgradmedj-64-769.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/756\/769\/50079025\/postgradmedj-64-769.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T04:38:25Z","timestamp":1683261505000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/64\/756\/769\/7047630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10,1]]},"references-count":4,"journal-issue":{"issue":"756","published-online":{"date-parts":[[1988,10,1]]},"published-print":{"date-parts":[[1988,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.64.756.769","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,10]]},"published":{"date-parts":[[1988,10,1]]}}}