{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:59:00Z","timestamp":1768553940273,"version":"3.49.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"758","license":[{"start":{"date-parts":[[1988,12,1]],"date-time":"1988-12-01T00:00:00Z","timestamp":596937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>In a prospective study, three antral biopsies were taken from 175 dyspeptic patients during routine endoscopy. One biopsy was inserted immediately into a gel-containing well of a CLOtest slide and two biopsies were sent to histopathology. Using the CLOtest, 84 of the 175 samples (48%) detected urease activity in the gastric biopsy, suggesting infection with Campylobacter pylori. Histopathological examination by two independent observers reported that 93 (52%) of the biopsies contained Campylobacter-like organisms. The CLOtest was found to have a specificity of 1.0 and sensitivity of 0.91, providing a rapid identification of most patients harbouring the organism in their gastric mucus.<\/jats:p>","DOI":"10.1136\/pgmj.64.758.935","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"935-936","source":"Crossref","is-referenced-by-count":11,"title":["Rapid urease test provides specific identification of Campylobacter pylori in antral mucosal biopsies"],"prefix":"10.1093","volume":"64","author":[{"given":"M L","family":"Szeto","sequence":"first","affiliation":[{"name":"Academic Department of Medicine, Rowland Hill Street , London NW3 2PF , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R E","family":"Pounder","sequence":"additional","affiliation":[{"name":"Academic Department of Medicine, Rowland Hill Street , London NW3 2PF , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S J","family":"Hamilton-Dutoit","sequence":"additional","affiliation":[{"name":"Academic Department of Histopathology, Royal Free Hospital School of Medicine, Rowland Hill Street , London NW3 2PF , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Academic Department of Histopathology, Royal Free Hospital School of Medicine, Rowland Hill Street , London NW3 2PF , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,12,1]]},"reference":[{"issue":"1","key":"ref_1","first-page":"527","article-title":"Significance of Campylobacter pylori","volume":"1","author":"Tytgat, G.N.J.; Rauws, E.A.J.","year":"1987","unstructured":"Tytgat, G.N.J. & Rauws, E.A.J. Significance of Campylobacter pylori. Aliment Pharmacol Therap 1987, 1 (suppl 1): 527S-539S.","journal-title":"Aliment Pharmacol Therap"},{"issue":"108","key":"ref_2","first-page":"70","article-title":"The clinical significance of Campylobacter pylori","volume":"1988","author":"Dooley, C.P.; Cohen, H.","unstructured":"Dooley, C.P. & Cohen, H. The clinical significance of Campylobacter pylori. Ann Int Med 1988, 108: 70-79.","journal-title":"Ann Int Med"},{"issue":"94","key":"ref_3","first-page":"229","article-title":"Campylobacter pylori: fact or fancy?","volume":"1988","author":"Bartlett, J.E.","unstructured":"Bartlett, J.E. Campylobacter pylori: fact or fancy? Gastroenterology 1988, 94: 229-238.","journal-title":"Gastroenterology"},{"key":"ref_4","first-page":"200","article-title":"Rapid urease test in the management of Campylobacter pyloridisassociated gastritis","volume":"82","author":"Marshall, B.J.; Warren, J.R.; Francis, G.J.; Langton, S.R.; Goodwin, C.S.; Blincow, E.D.","year":"1987","unstructured":"Marshall, B.J., Warren, J.R., Francis, G.J., Langton, S.R., Goodwin, C.S. & Blincow, E.D. Rapid urease test in the management of Campylobacter pyloridisassociated gastritis. Am J Gastroenterol 1987, 82: 200-210.","journal-title":"Am J Gastroenterol"},{"key":"ref_5","first-page":"236","article-title":"Comparison of biopsy urease test and histologic examination for detection of Campylobacter pylori in duodenal, antral and fundic biopsies","volume":"34","author":"Borsch, G.; Adamek, R.; Sandmann, M.","year":"1987","unstructured":"Borsch, G., Adamek, R., Sandmann, M. et al. Comparison of biopsy urease test and histologic examination for detection of Campylobacter pylori in duodenal, antral and fundic biopsies. Hepatogastroenterol 1987, 34: 236-241.","journal-title":"Hepatogastroenterol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/758\/935\/50078765\/postgradmedj-64-935.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/758\/935\/50078765\/postgradmedj-64-935.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T04:48:11Z","timestamp":1683262091000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/64\/758\/935\/7047901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12,1]]},"references-count":5,"journal-issue":{"issue":"758","published-online":{"date-parts":[[1988,12,1]]},"published-print":{"date-parts":[[1988,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.64.758.935","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,12]]},"published":{"date-parts":[[1988,12,1]]}}}