{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T05:10:19Z","timestamp":1683263419024},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"758","license":[{"start":{"date-parts":[[1988,12,1]],"date-time":"1988-12-01T00:00:00Z","timestamp":596937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Two cases of primary hypothyroidism with hypopituitarism in elderly patients are reported. The elevated levels of thyroid stimulating hormone led to delay in the recognition of accompanying pituitary failure. Elderly patients should not be commenced on thyroxine replacement therapy until the possibility of hypopituitarism and cortisol deficiency has been excluded.<\/jats:p>","DOI":"10.1136\/pgmj.64.758.943","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"943-944","source":"Crossref","is-referenced-by-count":0,"title":["Hypopituitarism in the elderly in the presence of elevated thyroid stimulating hormone levels"],"prefix":"10.1093","volume":"64","author":[{"given":"T","family":"Beringer","sequence":"first","affiliation":[{"name":"Geriatric Medical Unit , Belfast BT12 6BA , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"McClements","sequence":"additional","affiliation":[{"name":"Geriatric Medical Unit , Belfast BT12 6BA , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Weir","sequence":"additional","affiliation":[{"name":"Geriatric Medical Unit , Belfast BT12 6BA , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Gilmore","sequence":"additional","affiliation":[{"name":"Geriatric Medical Unit , Belfast BT12 6BA , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Kennedy","sequence":"additional","affiliation":[{"name":"The Sir George E. Clark Metabolic Unit, Royal Victoria Hospital , Belfast BT12 6BA , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,12,1]]},"reference":[{"key":"ref_1","first-page":"211","article-title":"Thyroid disorders","volume-title":"Metabolic and Nutritional Disorders in the Elderly","author":"Hodkinson, M.","year":"1980","unstructured":"Hodkinson, M. Thyroid disorders. In: Exton-Smith, A.N. & Caird, F.I. (eds) Metabolic and Nutritional Disorders in the Elderly. John Wright, Bristol, 1980, pp 211-219."},{"issue":"291","key":"ref_2","first-page":"247","article-title":"Idiopathic hypopituitarism in the elderly","volume":"1985","author":"Belchetz, P.E.","unstructured":"Belchetz, P.E. Idiopathic hypopituitarism in the elderly. Br Med J 1985, 291: 247-248.","journal-title":"Br Med J"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/ageing\/3.3.152","article-title":"Evaluation of a ten-question mental test in institutionalised elderly","volume":"3","author":"Qureshi, K.N.; Hodkinson, H.M.","year":"1974","unstructured":"Qureshi, K.N. & Hodkinson, H.M. Evaluation of a ten-question mental test in institutionalised elderly. Age Ageing 1974, 3: 152-157.","journal-title":"Age Ageing"},{"key":"ref_4","first-page":"989","article-title":"Thyrotropin secretion in patients with central hypothyroidism: evidence for reduced biological activity of immunoreactive thyrotropin","volume":"48","author":"Faglia, G.; Bitensky, L.; Pinchera, A.","year":"1979","unstructured":"Faglia, G., Bitensky, L., Pinchera, A. et al. Thyrotropin secretion in patients with central hypothyroidism: evidence for reduced biological activity of immunoreactive thyrotropin. J Clin Endocrinol Metab 1979, 48: 989-998. The presence of an elevated TSH level in association with lowered thyroid hormone secretion cannot be assumed to indicate intact anterior pituitary function. These cases highlight the need to consider carefully the possibility of hypopituitarism in elderly patients with apparent primary hypothyroidism before commencing thyroxine replacement therapy.","journal-title":"J Clin Endocrinol Metab; The presence of an elevated TSH level in association with lowered thyroid hormone secretion cannot be assumed to indicate intact anterior pituitary function. These cases highlight the need to consider carefully the possibility of hypopituitarism in elderly patients with apparent primary hypothyroidism before commencing thyroxine replacement therapy"},{"issue":"291","key":"ref_5","first-page":"127","article-title":"Muscle contractures associated with glucocorticoid deficiency","volume":"1985","author":"Blandford, R.L.; Samanta, A.K.; Burden, A.C.; Rosenthal, F.D.","unstructured":"Blandford, R.L., Samanta, A.K., Burden, A.C. & Rosenthal, F.D. Muscle contractures associated with glucocorticoid deficiency. Br Med J 1985, 291: 127-128.","journal-title":"Br Med J"},{"issue":"83","key":"ref_6","first-page":"584","article-title":"Anterior hypophysitis and Hashimoto's disease in a young woman","volume":"1962","author":"Goudie, R.B.; Pinkerton, P.H.","unstructured":"Goudie, R.B. & Pinkerton, P.H. Anterior hypophysitis and Hashimoto's disease in a young woman. J Pathol Bact 1962, 83: 584-585.","journal-title":"J Pathol Bact"},{"key":"ref_7","first-page":"548550","article-title":"Hypophysitis and hypopituitarism: report of a case","volume":"2","author":"Hume, R.; Roberts, G.H.","year":"1967","unstructured":"Hume, R. & Roberts, G.H. Hypophysitis and hypopituitarism: report of a case. Br Med J 1967, 2: 548550.","journal-title":"Br Med J"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0002-9343(84)90710-1","article-title":"Primary hypothyroidism and hypopituitarism in a young woman","volume":"77","author":"Ludmerer, K.M.; Kissane, J.M.","year":"1984","unstructured":"Ludmerer, K.M. & Kissane, J.M. Primary hypothyroidism and hypopituitarism in a young woman. Am J Med 1984, 77: 319-330.","journal-title":"Am J Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/758\/943\/50079075\/postgradmedj-64-943.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/758\/943\/50079075\/postgradmedj-64-943.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T04:49:29Z","timestamp":1683262169000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/64\/758\/943\/7047859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12,1]]},"references-count":8,"journal-issue":{"issue":"758","published-online":{"date-parts":[[1988,12,1]]},"published-print":{"date-parts":[[1988,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.64.758.943","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,12]]},"published":{"date-parts":[[1988,12,1]]}}}