{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:33:52Z","timestamp":1757586832046},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"758","license":[{"start":{"date-parts":[[1988,12,1]],"date-time":"1988-12-01T00:00:00Z","timestamp":596937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 42 year old heterosexual male with symptomatic human immunodeficiency virus infection presented with a 2-week history of tense blistering skin lesions following azidothymidine therapy. Urinary porphyrin excretion confirmed the diagnosis of porphyria cutanea tarda. The blisters resolved following the withdrawal of the drug but recurred when rechallenged. Three other cases of porphyria cutanea tarda, not associated with azidothymidine, who subsequently developed acquired immunodeficiency syndrome have recently been described. If azidothymidine is not the precipitating agent, it is possible that human immunodeficiency virus itself can impair porphyrin metabolism, leading to the clinical and biochemical features of porphyria cutanea tarda.<\/jats:p>","DOI":"10.1136\/pgmj.64.758.956","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"956-957","source":"Crossref","is-referenced-by-count":7,"title":["Porphyria cutanea tarda in association with the human immunodeficiency virus infection"],"prefix":"10.1093","volume":"64","author":[{"given":"E L C","family":"Ong","sequence":"first","affiliation":[{"name":"Regional Department of Infectious Diseases and Tropical Medicine, Monsall Hospital , Manchester MJO 8WR , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E","family":"Ellis","sequence":"additional","affiliation":[{"name":"Regional Department of Infectious Diseases and Tropical Medicine, Monsall Hospital , Manchester MJO 8WR , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"McDowell","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Hope Hospital, Eccles Old Road , Salford M6 8HD , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Gebril","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Hope Hospital, Eccles Old Road , Salford M6 8HD , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Weinkove","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Hope Hospital, Eccles Old Road , Salford M6 8HD , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Ead","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Monsall Hospital , Manchester MJO 8WR , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,12,1]]},"reference":[{"key":"ref_1","first-page":"pp","article-title":"The porphyrias","volume-title":"The Metabolic Basis of Inherited Disease","author":"Kappas, A.; Sassa, S.; Anderson, K.E.","year":"1982","unstructured":"Kappas, A., Sassa, S. & Anderson, K.E. The porphyrias. In: Stansbury, J.B., Wyngaarden, J.B., Frederickson, D.S., Goldstein, J.L., & Brown, M.S. (eds) The Metabolic Basis of Inherited Disease, 5th edition. McGraw-Hill, New York, 1982, pp 1301.","edition":"5th edition"},{"key":"ref_2","first-page":"227","article-title":"Porphyria metabolism in porphyria cutanea tarda","volume":"14","author":"Elder, G.H.","year":"1977","unstructured":"Elder, G.H. Porphyria metabolism in porphyria cutanea tarda. Semin Haematol 1977, 14: 227.","journal-title":"Semin Haematol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/326200a0","article-title":"Suppression of in vitro haematopoiesis following human immunodeficiency virus factors","volume":"326","author":"Donahue, R.E.; Johnson, M.M.; Zon, L.I.; Clark, S.C.; Groopman, J.E.","year":"1987","unstructured":"Donahue, R.E., Johnson, M.M., Zon, L.I., Clark, S.C. & Groopman, J.E. Suppression of in vitro haematopoiesis following human immunodeficiency virus factors. Nature 1987, 326: 200-203.","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ajh.2830250112","article-title":"Porphyria cutanea tarda associated with the acquired immune deficiency syndrome","volume":"25","author":"Wissel, P.S.; Sordillo, P.; Anderson, K.E.; Sassa, S.; Savillo, R.L.; Kappas, A.","year":"1987","unstructured":"Wissel, P.S., Sordillo, P., Anderson, K.E., Sassa, S., Savillo, R.L. & Kappas, A. Porphyria cutanea tarda associated with the acquired immune deficiency syndrome. Am J Hematol 1987, 25: 107-113.","journal-title":"Am J Hematol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/758\/956\/50078791\/postgradmedj-64-956.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/758\/956\/50078791\/postgradmedj-64-956.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T04:49:31Z","timestamp":1683262171000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/64\/758\/956\/7047841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12,1]]},"references-count":4,"journal-issue":{"issue":"758","published-online":{"date-parts":[[1988,12,1]]},"published-print":{"date-parts":[[1988,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.64.758.956","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,12]]},"published":{"date-parts":[[1988,12,1]]}}}