{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:21Z","timestamp":1761058881859},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"759","license":[{"start":{"date-parts":[[1989,1,1]],"date-time":"1989-01-01T00:00:00Z","timestamp":599616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A severe hypersensitivity-like illness with acute renal failure, lymphadenopathy and skin rash is reported following minocycline treatment in a 16 year old male. Following haemodialysis and steroid therapy his illness remitted, only to recur on withdrawal of the steroids. With further steroid treatment he recovered completely. Lymphocyte function tests, performed in an attempt to positively incriminate minocycline, were inconclusive due to a general suppression of the patient\u2019s lymphocytes to in vitro stimulation. Hypersensitivity reactions attributed to minocycline include skin rashes, lymphadenopathy and one previous case of acute interstitial nephritis.<\/jats:p>","DOI":"10.1136\/pgmj.65.759.53","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"53-56","source":"Crossref","is-referenced-by-count":17,"title":["Protracted systemic illness and interstitial nephritis due to minocycline"],"prefix":"10.1093","volume":"65","author":[{"given":"S P","family":"Wilkinson","sequence":"first","affiliation":[{"name":"Department of Medicine , Dundee DDI 9SY , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W K","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Medicine , Dundee DDI 9SY , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E M","family":"Spiers","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ninewells Hospital and Medical School , Dundee DDI 9SY , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Pears","sequence":"additional","affiliation":[{"name":"Department of Medicine , Dundee DDI 9SY , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1989,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/bmj.1.6162.524","article-title":"Minocycline-induced acute interstitial nephritis","volume":"1","author":"Walker, R.G.; Thomson, N.M.; Dowling, J.P.; Ogg, C.S.","year":"1979","unstructured":"Walker, R.G., Thomson, N.M., Dowling, J.P. & Ogg, C.S. Minocycline-induced acute interstitial nephritis. Br Med J 1979, 1: 524.","journal-title":"Br Med J"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2125.1983.tb04975.x","article-title":"Some tetracycline drugs suppress mitogen-stimulated lymphocyte growth but others do not","volume":"16","author":"Potts, R.C.; MacConnachie, A.; Brown, R.A.","year":"1983","unstructured":"Potts, R.C., MacConnachie, A., Brown, R.A. et al. Some tetracycline drugs suppress mitogen-stimulated lymphocyte growth but others do not. Br J Clin Pharmacol 1983, 16: 127-132.","journal-title":"Br J Clin Pharmacol"},{"key":"ref_3","first-page":"194","article-title":"Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy. Q JMed 1983,52","author":"Pusey, C.D.; Saltissi, D.; Bloodworth, L.; Rainford, D.J.; Christie, J.L.","unstructured":"Pusey, C.D., Saltissi, D., Bloodworth, L., Rainford, D.J. & Christie, J.L. Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy. Q JMed 1983,52:194-211."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/0002-9343(78)90793-3","article-title":"Acute interstitial nephritis due to methicillin","volume":"65","author":"Galpin, J.E.; Shinaberger, J.H.; Stanley, T.M.","year":"1978","unstructured":"Galpin, J.E., Shinaberger, J.H., Stanley, T.M. et al. Acute interstitial nephritis due to methicillin. Am J Med 1978, 65: 756-765.","journal-title":"Am J Med"},{"issue":"66","key":"ref_5","first-page":"97","article-title":"Allergic interstitial nephritis: clinical features and pathogenesis","volume":"1988","author":"Cameron, J.S.","unstructured":"Cameron, J.S. Allergic interstitial nephritis: clinical features and pathogenesis. Q J Med 1988, 66: 97-115.","journal-title":"Q J Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1600-0560.1987.tb00493.x","article-title":"Minocycline-related cutaneous hyperpigmentation as demonstrated by light microscopy, electron microscopy and X-ray energy spectroscopy","volume":"14","author":"Argenyi, Z.B.; Finelli, L.; Bergfeld, W.F.","year":"1987","unstructured":"Argenyi, Z.B., Finelli, L., Bergfeld, W.F. et al. Minocycline-related cutaneous hyperpigmentation as demonstrated by light microscopy, electron microscopy and X-ray energy spectroscopy. J Cut Pathol 1987, 14: 176-180.","journal-title":"J Cut Pathol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1001\/archderm.1987.01660250022003","article-title":"Stevens-Johnson syndrome due to minocycline therapy (letter)","volume":"123","author":"Shoji, A.; Sormeda, Y.; Hamada, T.","year":"1987","unstructured":"Shoji, A., Sormeda, Y. & Hamada, T. Stevens-Johnson syndrome due to minocycline therapy (letter). Arch Dermatol 1987, 123: 18-20.","journal-title":"Arch Dermatol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.me.29.020178.001203","article-title":"Immunological aspects of renal tubular and interstitial diseases","volume":"29","author":"McLuskey, R.T.; Colvin, R.B.","year":"1978","unstructured":"McLuskey, R.T. & Colvin, R.B. Immunological aspects of renal tubular and interstitial diseases. Ann Rev Med 1978, 29: 191-203.","journal-title":"Ann Rev Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0022-3476(77)81318-8","article-title":"Interstitial nephritis due to phenytoin hypersensitivity","volume":"91","author":"Sheth, K.J.; Casper, J.T.; Good, T.A.","year":"1977","unstructured":"Sheth, K.J., Casper, J.T. & Good, T.A. Interstitial nephritis due to phenytoin hypersensitivity. J Pediatr 1977, 91: 438-441.","journal-title":"J Pediatr"},{"issue":"16","key":"ref_10","first-page":"94","article-title":"Diphenylhydantoin-induced hypersensitivity reaction with interstitial nephritis","volume":"1985","author":"Matson, J.R.; Krous, H.F.; Blackstock, R.","unstructured":"Matson, J.R., Krous, H.F. & Blackstock, R. Diphenylhydantoin-induced hypersensitivity reaction with interstitial nephritis. Hum Pathol 1985, 16: 94-97.","journal-title":"Hum Pathol"},{"key":"ref_11","first-page":"151","article-title":"A decade of penicillin related interstitial nephritis - more","volume":"13","author":"Appel, G.B.","year":"1980","unstructured":"Appel, G.B. A decade of penicillin related interstitial nephritis - more questions than answers. Clin Nephrol 1980, 13: 151-154.","journal-title":"questions than answers. Clin Nephrol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/65\/759\/53\/50076414\/postgradmedj-65-53.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/65\/759\/53\/50076414\/postgradmedj-65-53.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T09:42:59Z","timestamp":1683193379000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/65\/759\/53\/7044342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1,1]]},"references-count":11,"journal-issue":{"issue":"759","published-online":{"date-parts":[[1989,1,1]]},"published-print":{"date-parts":[[1989,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.65.759.53","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1989,1]]},"published":{"date-parts":[[1989,1,1]]}}}