{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T13:30:36Z","timestamp":1698240636550},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"761","license":[{"start":{"date-parts":[[1989,3,1]],"date-time":"1989-03-01T00:00:00Z","timestamp":604713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,3,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We describe two cases of dysgenesis of the corpus callosum demonstrated by magnetic resonance. The first patient presented with chronic hyponatraemia. Investigation demonstrated re-setting of the osmoreceptor and thirst centres. The calculated threshold for arginine vasopressin (AVP) release was reduced at 252 mosmol\/kg while severe thirst was perceived at a plasma osmolality of 260 mosmol\/kg. Insulin-induced hypoglycaemia produced an exaggerated AVP response. The second patient presented with hypothermia. The calculated threshold of AVP release was 296 mosmol\/kg with increased sensitivity of AVP response to hypertonic saline. The plasma AVP response to insulin-induced hypoglycaemia was absent. Both cases had normal anterior pituitary function and psychological assessment showed a similar prefrontal defect. Specific tests of callosal function were normal. These cases illustrate the importance of undertaking complete neuroradiological assessment of cases of unexplained hypothalamic disease regardless of the age of presentation to avoid overlooking this rare congenital association.<\/jats:p>","DOI":"10.1136\/pgmj.65.761.163","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"163-167","source":"Crossref","is-referenced-by-count":6,"title":["Hypothalamic disease in association with dysgenesis of the corpus callosum"],"prefix":"10.1093","volume":"65","author":[{"given":"S R","family":"Page","sequence":"first","affiliation":[{"name":"Department of Medicine II, St. George\u2019s Hospital Medical School , Cranmer Terrace, London SW17 ORE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S S","family":"Nussey","sequence":"additional","affiliation":[{"name":"Department of Medicine II, St. George\u2019s Hospital Medical School , Cranmer Terrace, London SW17 ORE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Medicine II, St. George\u2019s Hospital Medical School , Cranmer Terrace, London SW17 ORE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S G","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Neurology , Copse Hill, London SE20 ONE , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology, Atkinson Morley Hospital, Copse Hill , London SE20 ONE , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1989,3,1]]},"reference":[{"issue":"18","key":"ref_1","first-page":"745","article-title":"Clinicopathological correlations in agenesis of the corpus callosum","volume":"1968","author":"Loeser, J.D.; Ellsworth, Jr, C.A.","unstructured":"Loeser, J.D. & Ellsworth, C.A. Jr. Clinicopathological correlations in agenesis of the corpus callosum. Neurology 1968, 18: 745-756.","journal-title":"Neurology"},{"key":"ref_2","first-page":"691","article-title":"Inappropriate secretion of antidiuretic hormone, hypertension and hypoplastic corpus callosum","volume":"45","author":"Fyhrquist, F.; Holmberg, C.; Perheentupa, J.; Wallenius, M.","year":"1976","unstructured":"Fyhrquist, F., Holmberg, C., Perheentupa, J. & Wallenius, M. Inappropriate secretion of antidiuretic hormone, hypertension and hypoplastic corpus callosum. J Clin Endocrinol Metab 1976, 45: 691-694.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0022-3476(84)80601-0","article-title":"Chronic reset osmoreceptor response, agenesis of the corpus callosum, and hypothalamic cyst","volume":"104","author":"Bannister, P.; Sheridan, P.; Penney, M.D.","year":"1984","unstructured":"Bannister, P., Sheridan, P. & Penney, M.D. Chronic reset osmoreceptor response, agenesis of the corpus callosum, and hypothalamic cyst. J Pediatr 1984, 104: 97-99.","journal-title":"J Pediatr"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/brain\/96.2.359","article-title":"Agenesis of the corpus callosum associated with relapsing hypothermia. A clinicopathological study","volume":"96","author":"Noel, P.; Ectors, H.M.; Franken, L.; Flament-Durand, J.","year":"1973","unstructured":"Noel, P., Ectors, H.M., Franken, L. & Flament-Durand, J. Agenesis of the corpus callosum associated with relapsing hypothermia. A clinicopathological study. Brain 1973, 96: 359 - 368.","journal-title":"Brain"},{"issue":"291","key":"ref_5","first-page":"111","article-title":"oxytocin and neurophysins in the human brain and spinal cord","volume":"1984","author":"Jenkins, J.S.; Ang, V.T.Y.; Hawthorn, J.; Rosser, M.N.; Iverson, L.L.Vasopressin","unstructured":"Jenkins, J.S., Ang, V.T.Y., Hawthorn, J., Rosser, M.N. & Iverson, L.L. Vasopressin, oxytocin and neurophysins in the human brain and spinal cord. Brain Res 1984, 291: 111-117.","journal-title":"Brain Res"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0022-4731(84)90064-5","article-title":"Direct determination of aldosterone in human saliva","volume":"21","author":"Few, J.D.; Chaudrey, S.; James, V.H.T.","year":"1984","unstructured":"Few, J.D., Chaudrey, S. & James, V.H.T. Direct determination of aldosterone in human saliva. 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Kidney Int 1976, 10: 25-37.","journal-title":"Kidney Int"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0002-9343(78)90581-8","article-title":"The role of vasopressin in the impaired water excretion of myxoedema","volume":"64","author":"Skowsky, W.R.; Kiruchi, T.A.","year":"1978","unstructured":"Skowsky, W.R. & Kiruchi, T.A. The role of vasopressin in the impaired water excretion of myxoedema. Am J Med 1978, 64: 613.","journal-title":"Am J Med"},{"key":"ref_13","first-page":"136","article-title":"Regulation of aldosterone in the syndrome of inappropriate antidiuretic hormone secretion (SIADH)","volume":"39","author":"Fichman, M.P.; Michelakis, A.M.; Horton, R.","year":"1973","unstructured":"Fichman, M.P., Michelakis, A.M. & Horton, R. Regulation of aldosterone in the syndrome of inappropriate antidiuretic hormone secretion (SIADH). 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Disconnection syndromes in animals and man. Brain 1965, 88: 237-294; 585-644.","journal-title":"Brain"},{"issue":"26","key":"ref_17","first-page":"328","article-title":"Lipoma of the corpus callosum: A non surgical entity","volume":"1965","author":"Patel, A.N.","unstructured":"Patel, A.N. Lipoma of the corpus callosum: A non surgical entity. N Carolina Med J 1965, 26: 328.","journal-title":"N Carolina Med J"},{"issue":"44","key":"ref_18","first-page":"1094","article-title":"Spontaneous periodic hypothermia with lipoma of the corpus callosum","volume":"1981","author":"Summers, G.D.; Young, A.C.; Little, R.A.; Stoner, H.B.; Forbes, W.S.T.C.; Jones, R.A.C.","unstructured":"Summers, G.D., Young, A.C., Little, R.A., Stoner, H.B., Forbes, W.S.T.C. & Jones, R.A.C. Spontaneous periodic hypothermia with lipoma of the corpus callosum. 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Neurology 1978, 28: 1272-1279.","journal-title":"Neurology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0093-934X(80)90116-9","article-title":"A house divided? cognitive function with callosal agenesis","volume":"11","author":"Chiarello, C.","year":"1980","unstructured":"Chiarello, C. A house divided? cognitive function with callosal agenesis. Brain Lang 1980, 11: 128-158.","journal-title":"Brain Lang"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/brain\/95.2.327","article-title":"Agenesis of the corpus callosum: a behavioural investigation","volume":"95","author":"Ettlinger, G.; Blakemore, C.B.; Milner, A.D.; Wilson, J.","year":"1972","unstructured":"Ettlinger, G., Blakemore, C.B., Milner, A.D. & Wilson, J. Agenesis of the corpus callosum: a behavioural investigation. 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