{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:00:08Z","timestamp":1765666808035},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"762","license":[{"start":{"date-parts":[[1989,4,1]],"date-time":"1989-04-01T00:00:00Z","timestamp":607392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,4,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A 41 year old female developed reactive haemophagocytic histiocytosis secondary to herpes simplex infection, during remission induction for acute lymphoblastic leukaemia. She recovered fully with acyclovir and supportive treatment. Previous publications on the association between acute lymphoblastic leukaemia and haemophagocytic syndrome are reviewed, and the nature of the haemophagocytic disorder is discussed.<\/jats:p>","DOI":"10.1136\/pgmj.65.762.249","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"249-252","source":"Crossref","is-referenced-by-count":4,"title":["Haemophagocytic syndrome complicating acute lymphoblastic leukaemia"],"prefix":"10.1093","volume":"65","author":[{"given":"R","family":"Stark","sequence":"first","affiliation":[{"name":"Department of Clinical Haematology, St George Hospital, University of New South Wales , Sydney , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Manoharan","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology, St George Hospital, University of New South Wales , Sydney , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1989,4,1]]},"reference":[{"key":"ref_1","first-page":"194","article-title":"Histiocytic medullary reticulosis","volume":"ii:","author":"Scott, R.B.; Robb-Smith, A.H.T.","unstructured":"Scott, R.B. & Robb-Smith, A.H.T. Histiocytic medullary reticulosis. Lancet 1939, ii: 194-198.","journal-title":"Lancet 1939"},{"key":"ref_2","first-page":"49","article-title":"Tumors of the hemopoietic system. In: Atlas of Tumor Pathology, Sect III, Fasc 8","author":"Rappaport, H.","year":"1966","unstructured":"Rappaport, H. (ed.) Tumors of the hemopoietic system. In: Atlas of Tumor Pathology, Sect III, Fasc 8. Armed Forces Institute ofPathology, Washington, 1966, pp. 49, 442.","journal-title":"Armed Forces Institute ofPathology, Washington"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2141.1978.tb03640.x","article-title":"Malignant histiocytosis: a clinico-pathological study of 12 cases","volume":"40","author":"Lampert, I.A.; Catovsky, D.; Bergier, N.","year":"1978","unstructured":"Lampert, I.A., Catovsky, D. & Bergier, N. Malignant histiocytosis: a clinico-pathological study of 12 cases. Br J Haematol 1978, 40: 65-77.","journal-title":"Br J Haematol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/1097-0142(197909)44:3<993::AID-CNCR2820440329>3.0.CO;2-5","article-title":"Virus-associated hemophagocytic syndrome. A benign histiocytic proliferation distinct from malignant histiocytosis","volume":"44","author":"Risdall, R.J.; McKenna, R.W.; Nexbit, M.E.","year":"1979","unstructured":"Risdall, R.J., McKenna, R.W., Nexbit, M.E. et al. Virus-associated hemophagocytic syndrome. A benign histiocytic proliferation distinct from malignant histiocytosis. Cancer 1979, 44: 993-1002.","journal-title":"Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1002\/1097-0142(19841215)54:12<2968::AID-CNCR2820541226>3.0.CO;2-4","article-title":"Bacteria-associated hemophagocytic syndrome","volume":"54","author":"Risdall, R.J.; Brunning, R.D.; Hernandez, J.I.; Gordon, D.H.","year":"1984","unstructured":"Risdall, R.J., Brunning, R.D., Hernandez, J.I. & Gordon, D.H. Bacteria-associated hemophagocytic syndrome. Cancer 1984, 54: 2968-2972.","journal-title":"Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1600-0609.1979.tb02744.x","article-title":"'Lennert's lymphoma' terminating as malignant histiocytosis","volume":"23","author":"Economopoulos, T.C.; Stathakis, N.; Stathopoulos, E.; Alexopoulos, C.","year":"1979","unstructured":"Economopoulos, T.C., Stathakis, N., Stathopoulos, E. & Alexopoulos, C. 'Lennert's lymphoma' terminating as malignant histiocytosis. Scand J Haematol 1979, 23: 427-432.","journal-title":"Scand J Haematol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/0002-9343(83)90402-3","article-title":"Malignant lymphoma and erythrophagocytosis simulating malignant histiocytosis","volume":"75","author":"Jaffe, E.S.; Costa, J.; Fauci, A.S.; Cossman, J.; Tsokos, M.","year":"1983","unstructured":"Jaffe, E.S., Costa, J., Fauci, A.S., Cossman, J., Tsokos, M. Malignant lymphoma and erythrophagocytosis simulating malignant histiocytosis. Am J Med 1983, 75: 741-649.","journal-title":"Am J Med"},{"issue":"58","key":"ref_8","first-page":"1289","article-title":"Reactive histiocytosis in acute lymphoblastic leukemia and nonHodgkin's lymphoma","volume":"1986","author":"Liang, D.C.; Chu, M.L.; Shih, C.C.","unstructured":"Liang, D.C., Chu, M.L. & Shih, C.C. Reactive histiocytosis in acute lymphoblastic leukemia and nonHodgkin's lymphoma. Cancer 1986, 58: 1289-1294.","journal-title":"Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/1097-0142(197710)40:4<1735::AID-CNCR2820400450>3.0.CO;2-F","article-title":"Acute myelomonocytic leukemia terminating in histiocytic medullary reticulosis. Cytochemical, cytogenetic and electron microscopic studies","volume":"40","author":"Castoldi, G.; Grusovin, G.D.; Scapoli, G.; Gualandi, M.; Spanedda, R.; Anzanel, D.","year":"1977","unstructured":"Castoldi, G., Grusovin, G.D., Scapoli, G., Gualandi, M., Spanedda, R. & Anzanel, D. Acute myelomonocytic leukemia terminating in histiocytic medullary reticulosis. Cytochemical, cytogenetic and electron microscopic studies. Cancer 1977, 40: 1735-1747.","journal-title":"Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-0609.1981.tb01617.x","article-title":"Histiocytic medullary reticulosis complicating chronic lymphocytic leukaemia: malignant or reactive","volume":"26","author":"Manoharan, A.; Catovsky, D.; Lampert, I.A.; Mashadhani, A.; Gordon-Smith, E.C.; Galton, D.A.G.","year":"1981","unstructured":"Manoharan, A., Catovsky, D., Lampert, I.A., Mashadhani, A., Gordon-Smith, E.C. & Galton, D.A.G. Histiocytic medullary reticulosis complicating chronic lymphocytic leukaemia: malignant or reactive. Scand J Haematol 1981, 26: 5-13.","journal-title":"Scand J Haematol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.7326\/0003-4819-91-1-60","article-title":"Hodgkin's disease: intramedullary phagocytosis with pancytopenia","volume":"91","author":"Korman, L.Y.; Robert-Smith, J.; Landaw, S.A.; Davey, F.R.","year":"1979","unstructured":"Korman, L.Y., Robert-Smith, J., Landaw, S.A. & Davey, F.R. Hodgkin's disease: intramedullary phagocytosis with pancytopenia. Ann Intern Med 1979, 91: 60-61.","journal-title":"Ann Intern Med"},{"key":"ref_12","article-title":"Histiocytic medullary reticulosis","volume":"58","author":"Schumacher, H.R.; Stass, S.A.","year":"1979","unstructured":"Schumacher, H.R. & Stass, S.A. Histiocytic medullary reticulosis. Lancet 1979, i: 58.","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-3-642-81696-3_23","article-title":"Histiocytic medullary reticulosis revisited","volume":"27","author":"Manoharan, A.; Catovsky, D.","year":"1981","unstructured":"Manoharan, A. & Catovsky, D. Histiocytic medullary reticulosis revisited. In: Schmalze, Huhn & Schaeffer (eds) Haematology and Blood Transfusion, vol. 27. Disorders ofthe Monocyte Macrophage System. Springer Verlag, Berlin, 1981, pp. 205-210.","journal-title":"Transfusion; Haematology and Blood"},{"key":"ref_14","first-page":"47","article-title":"Histiocytic medullary reticulosis presenting with a leukemic blood picture","volume":"1969","author":"Clark, B.S.; Dawson, P.J.","unstructured":"Clark, B.S. & Dawson, P.J. Histiocytic medullary reticulosis presenting with a leukemic blood picture. Am J Med 1969, 47: 314-317.","journal-title":"Am J Med"},{"key":"ref_15","first-page":"256","article-title":"Acute leukemia terminating in histiocytic medullary reticulosis","volume":"93","author":"Skarin, A.T.; Karb, K.; Reynolds, E.S.","year":"1972","unstructured":"Skarin, A.T., Karb, K. & Reynolds, E.S. Acute leukemia terminating in histiocytic medullary reticulosis. Arch Pathol 1972, 93: 256-260.","journal-title":"Arch Pathol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/1097-0142(197501)35:1<215::AID-CNCR2820350127>3.0.CO;2-H","article-title":"Malignant histiocytosis (histiocytic medullary reticulosis): clinicopathologic study of 29 cases","volume":"35","author":"Warnke, R.A.; Kim, H.; Dorfinan, R.F.","year":"1975","unstructured":"Warnke, R.A., Kim, H. & Dorfinan, R.F. Malignant histiocytosis (histiocytic medullary reticulosis): clinicopathologic study of 29 cases. Cancer 1975, 35: 215-230.","journal-title":"Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1001\/jama.1975.03240200036022","article-title":"Acute lymphoblastic leukemia terminating as histiocytic medullary reticulosis","volume":"231","author":"Sheriner, D.P.","year":"1975","unstructured":"Sheriner, D.P. Acute lymphoblastic leukemia terminating as histiocytic medullary reticulosis. JAMA 1975, 231: 838-840.","journal-title":"JAMA"},{"key":"ref_18","first-page":"1262","article-title":"Histiocytic medullary reticulosis in acute lymphocytic leukemia of T cell origin","volume":"130","author":"Chen, T.K.; Nesbit, M.E.; McKenna, R.; Kersey, J.H.","year":"1976","unstructured":"Chen, T.K., Nesbit, M.E., McKenna, R. & Kersey, J.H. Histiocytic medullary reticulosis in acute lymphocytic leukemia of T cell origin. Am J Dis Child 1976, 130: 1262-1264.","journal-title":"Am J Dis Child"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1002\/1097-0142(197805)41:5<1967::AID-CNCR2820410542>3.0.CO;2-7","article-title":"Malignant histiocytosis occurring in patients with acute lymphocytic leukemia","volume":"41","author":"Karcher, D.S.; Head, D.R.; Mullins, J.D.","year":"1978","unstructured":"Karcher, D.S., Head, D.R. & Mullins, J.D. Malignant histiocytosis occurring in patients with acute lymphocytic leukemia. Cancer 1978, 41: 1967-1973.","journal-title":"Cancer"},{"key":"ref_20","first-page":"47","article-title":"Histiocytic medullary reticulosis following acute lymphoblastic leukemia","volume":"1981","author":"Starkie, C.M.; Kenny, M.W.; Mann, J.R.; Cameron, A.M.; Hill, F.G.H.","unstructured":"Starkie, C.M., Kenny, M.W., Mann, J.R., Cameron, A.M. & Hill, F.G.H. Histiocytic medullary reticulosis following acute lymphoblastic leukemia. Cancer 1981, 47: 537-544.","journal-title":"Cancer"},{"key":"ref_21","first-page":"186","article-title":"Histiocytic medullary reticulosis (malignant histiocytosis) as a sequel of acute lymphoblastic leukemia in childhood","volume":"50","author":"Chesney, T.M.","year":"1979","unstructured":"Chesney, T.M. Histiocytic medullary reticulosis (malignant histiocytosis) as a sequel of acute lymphoblastic leukemia in childhood. Blood 1979, 50 (suppl): 186.","journal-title":"Blood"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/0002-9343(78)90590-9","article-title":"T-cell acute lymphocytic leukemia terminating as malignant histiocytosis","volume":"64","author":"Skoog, D.P.; Feagler, J.R.","year":"1978","unstructured":"Skoog, D.P. & Feagler, J.R. T-cell acute lymphocytic leukemia terminating as malignant histiocytosis. Am J Med 1978, 64: 678-682.","journal-title":"Am J Med"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0002-9343(78)90527-2","article-title":"Development of a histiocytic medullary reticulosis-like syndrome during the course of acute lymphocytic leukemia","volume":"64","author":"Griffin, J.D.; Ellman, L.; Long, J.C.; Dvorak, A.M.","year":"1978","unstructured":"Griffin, J.D., Ellman, L., Long, J.C. & Dvorak, A.M. Development of a histiocytic medullary reticulosis-like syndrome during the course of acute lymphocytic leukemia. Am J Med 1978, 64: 851-858.","journal-title":"Am J Med"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/ajcp\/73.5.725","article-title":"Null cell (non-T, non-B) acute lymphoblastic leukemia terminating as malignant histiocytosis","volume":"73","author":"Trubowitz, S.; Sobel, H.; Davis, S.","year":"1980","unstructured":"Trubowitz, S., Sobel, H. & Davis, S. Null cell (non-T, non-B) acute lymphoblastic leukemia terminating as malignant histiocytosis. Am J Clin Pathol 1980, 73: 725-730.","journal-title":"Am J Clin Pathol"},{"key":"ref_25","first-page":"446","article-title":"Is histiocytic medullary reticulosis an infectious disease?","volume":"ii:","author":"Martelli, M.F.; Tabilio, A.; Aversa, F.; Falini, B.; Rocchi, F.","year":"1982","unstructured":"Martelli, M.F., Tabilio, A., Aversa, F., Falini, B. & Rocchi, F. Is histiocytic medullary reticulosis an infectious disease? Lancet 1982, ii: 446-447.","journal-title":"Lancet"},{"key":"ref_26","first-page":"200","article-title":"Complete recovery of histiocytic medullary reticulosis-like syndrome in a child with acute lymphoblastic leukemia","volume":"51","author":"Yin, J.A.L.; Kumaran, T.O.; Marsh, G.W.; Rossiter, M.; Catovsky, D.","year":"1982","unstructured":"Yin, J.A.L., Kumaran, T.O., Marsh, G.W., Rossiter, M. & Catovsky, D. Complete recovery of histiocytic medullary reticulosis-like syndrome in a child with acute lymphoblastic leukemia. Cancer 1982, 51: 200-202.","journal-title":"Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/0002-9343(84)90541-2","article-title":"Association of T-cell acute lymphoblastic leukemia and histiocytic medullary reticulosis","volume":"77","author":"Rosner, F.; Grunwald, H.W.","year":"1984","unstructured":"Rosner, F. & Grunwald, H.W. Association of T-cell acute lymphoblastic leukemia and histiocytic medullary reticulosis. Am J Med 1984, 77: 910-914.","journal-title":"Am J Med"},{"issue":"61","key":"ref_28","first-page":"2071","article-title":"High serum ferritin level as a marker of malignant histiocytosis and virus-associated hemophagocytic syndrome","volume":"1988","author":"Esumi, N.; Ikushima, S.; Hibi, S.; Todo, S.; Imashuru, S.","unstructured":"Esumi, N., Ikushima, S., Hibi, S., Todo, S. & Imashuru, S. High serum ferritin level as a marker of malignant histiocytosis and virus-associated hemophagocytic syndrome. Cancer 1988, 61: 2071-2076.","journal-title":"Cancer"},{"issue":"94","key":"ref_29","first-page":"95","article-title":"The histiocytic disorder: A pathophysiological analysis","volume":"1981","author":"Groopman, J.E.; Gold, D.W.","unstructured":"Groopman, J.E. & Gold, D.W. The histiocytic disorder: A pathophysiological analysis. Ann Intern Med 1981,94: 95-107.","journal-title":"Ann Intern Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/65\/762\/249\/49243867\/postgradmedj-65-249.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/65\/762\/249\/49243867\/postgradmedj-65-249.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:09:19Z","timestamp":1709867359000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/65\/762\/249\/7044322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4,1]]},"references-count":29,"journal-issue":{"issue":"762","published-online":{"date-parts":[[1989,4,1]]},"published-print":{"date-parts":[[1989,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.65.762.249","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1989,4]]},"published":{"date-parts":[[1989,4,1]]}}}