{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:22Z","timestamp":1761058882639},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"764","license":[{"start":{"date-parts":[[1989,6,1]],"date-time":"1989-06-01T00:00:00Z","timestamp":612662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>There are three types of histological change in the carotid bodies which appear to have physiological and clinical associations. A prominence of the dark variant of chief cells with their contents of met-enkephalin and other peptides appears to be associated with acute exposure to hypoxia. Proliferation of sustentacular cells around the clusters of chief cells appears to be related to ageing and also to systemic hypertension.<\/jats:p>\n               <jats:p>Recently we have described a new condition of chronic carotid glomitis which is characterized by follicles of lymphocytes and may have a basis in auto-immunity. In the present review we report for the first time plasma cell activity in the carotid bodies of an elderly man, especially around nerve fibrils and unmyelinated axons ensheathed in sustentacular cells. Such appearances are consistent with the view that ageing nerve fibrils may be the antigenic stimulus for the development of chronic carotid glomitis.<\/jats:p>","DOI":"10.1136\/pgmj.65.764.353","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"353-357","source":"Crossref","is-referenced-by-count":5,"title":["Carotid body disease and the physician--chronic carotid glomitis"],"prefix":"10.1093","volume":"65","author":[{"given":"D","family":"Heath","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Liverpool, Duncan Building, Royal Liverpool Hospital , Liverpool L69 3BX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Liverpool, Duncan Building, Royal Liverpool Hospital , Liverpool L69 3BX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Nash","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Liverpool, Duncan Building, Royal Liverpool Hospital , Liverpool L69 3BX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Liverpool, Duncan Building, Royal Liverpool Hospital , Liverpool L69 3BX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1989,6,1]]},"reference":[{"key":"ref_1","article-title":"High-Altitude Medicine and Pathology","author":"Heath, D.; Williams, D.R.","year":"1989","unstructured":"Heath, D. & Williams, D.R. High-Altitude Medicine and Pathology. Butterworths, London, 1989."},{"key":"ref_2","first-page":"113","article-title":"Almitrine, hypoxia, systemic hypertension and the carotid body","author":"Barer, G.; Wach, R.; Pallot, D.; Bee, D.","year":"1986","unstructured":"Barer, G., Wach, R., Pallot, D. & Bee, D. Almitrine, hypoxia, systemic hypertension and the carotid body. In: Heath, D. (ed.) Aspects ofHypoxia. Liverpool University Press, Liverpool, 1986, pp. 113 - 129."},{"key":"ref_3","first-page":"19","article-title":"Pathology ofthe Carotid Body and Sinus","author":"Heath, D.; Smith, P.","year":"1985","unstructured":"Heath, D. & Smith, P. Pathology ofthe Carotid Body and Sinus. Edward Arnold, London, 1985, pp. 19-25."},{"issue":"32","key":"ref_4","first-page":"254","article-title":"The histology of the carotid bodies in highlanders from Ladakh","volume":"1988","author":"Khan, Q.; Heath, D.; Smith, P.; Norboo, T.","unstructured":"Khan, Q., Heath, D., Smith, P. & Norboo, T. The histology of the carotid bodies in highlanders from Ladakh. Int J Biometeorol 1988, 32: 254-259.","journal-title":"Int J Biometeorol"},{"issue":"95","key":"ref_5","first-page":"259","article-title":"Comparative pathology of the enlarged carotid body","volume":"1985","author":"Heath, D.; Smith, P.; Fitch, R.; Harris, P.","unstructured":"Heath, D., Smith, P., Fitch, R. & Harris, P. Comparative pathology of the enlarged carotid body. J Comp Pathol 1985, 95: 259-271.","journal-title":"J Comp Pathol"},{"issue":"10","key":"ref_6","first-page":"831","article-title":"The carotid bodies in a case of ventricular septal defect","volume":"1986","author":"Smith, P.; Hurst, G.; Heath, D.; Drewe, R.","unstructured":"Smith, P., Hurst, G., Heath, D. & Drewe, R. The carotid bodies in a case of ventricular septal defect. Histopathology 1986, 10: 831-840.","journal-title":"Histopathology"},{"key":"ref_7","article-title":"Ventilacion humana en hipoxia cronica. Etiopatogenia de la Enfermedad de Monge a desadaptacion cronica a la altura. Doctoral Thesis. Universidad Peruana Cayetano","author":"Sime, F.","year":"1973","unstructured":"Sime, F. Ventilacion humana en hipoxia cronica. Etiopatogenia de la Enfermedad de Monge a desadaptacion cronica a la altura. Doctoral Thesis. Universidad Peruana Cayetano Heredia, Lima, Peru, 1973."},{"issue":"147","key":"ref_8","first-page":"181","article-title":"Histological changes associated with ageing of the human carotid body","volume":"1985","author":"Hurst, G.; Heath, D.; Smith, P.","unstructured":"Hurst, G., Heath, D. & Smith, P. Histological changes associated with ageing of the human carotid body. J Pathol 1985, 147: 181-187.","journal-title":"J Pathol"},{"issue":"25","key":"ref_9","first-page":"217","article-title":"Irreversible respiratory insensitivity to acute hypoxia in man born at high altitude","volume":"1968","author":"Sorensen, S.C.; Severinghaus, J.W.","unstructured":"Sorensen, S.C. & Severinghaus, J.W. Irreversible respiratory insensitivity to acute hypoxia in man born at high altitude. J Appl Physiol 1968, 25: 217-220.","journal-title":"J Appl Physiol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/cvr\/16.3.163","article-title":"Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension","volume":"16","author":"Trzebski, A.; Tafil, M.; Zoltowski, M.; Przybylski, J.","year":"1982","unstructured":"Trzebski, A., Tafil, M., Zoltowski, M. & Przybylski, J. Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension. Cardiovase Res 1982, 16: 163-172.","journal-title":"Cardiovase Res"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/path.1711370404","article-title":"Anatomical variation and quantitative histology of the normal and enlarged carotid body","volume":"137","author":"Smith, P.; Jago, R.; Heath, D.","year":"1982","unstructured":"Smith, P., Jago, R. & Heath, D. Anatomical variation and quantitative histology of the normal and enlarged carotid body. J Pathol 1982, 137: 287-304.","journal-title":"J Pathol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0007-0971(86)90032-X","article-title":"The carotid bodies in coarctation of the aorta","volume":"80","author":"Heath, D.; Smith, P.; Hurst, G.","year":"1986","unstructured":"Heath, D., Smith, P. & Hurst, G. The carotid bodies in coarctation of the aorta. Br J Dis Chest 1986, 80: 122-130.","journal-title":"Br J Dis Chest"},{"issue":"1","key":"ref_13","first-page":"308","article-title":"Respiratory insensitivity to hypoxia in chronically hypoxic man","volume":"1966","author":"Severinghaus, J.W.; Bainton, C.R.; Carcelan, A.","unstructured":"Severinghaus, J.W., Bainton, C.R. & Carcelan, A. Respiratory insensitivity to hypoxia in chronically hypoxic man. Resp Physiol 1966, 1: 308-334.","journal-title":"Resp Physiol"},{"key":"ref_14","article-title":"Chronic carotid glomitis","author":"Khan, Q.; Heath, D.; Nash, J.; Smith, P.","year":"1989","unstructured":"Khan, Q., Heath, D., Nash, J. & Smith, P. Chronic carotid glomitis. Histopathology 1989 (in press).","journal-title":"Histopathology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/path.1711440408","article-title":"Focal lymphocytic thyroiditis in Southampton","volume":"144","author":"Mitchell, J.D.; Kirkham, N.; Machin, D.","year":"1984","unstructured":"Mitchell, J.D., Kirkham, N. & Machin, D. Focal lymphocytic thyroiditis in Southampton. J Pathol 1984, 144: 269-273.","journal-title":"J Pathol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1600-0714.1976.tb01785.x","article-title":"The incidence of focal chronic inflammatory changes in human submandibular salivary glands","volume":"5","author":"Scott, J.","year":"1976","unstructured":"Scott, J. The incidence of focal chronic inflammatory changes in human submandibular salivary glands. J Oral Pathol 1976, 5: 334-346.","journal-title":"J Oral Pathol"},{"issue":"108","key":"ref_17","first-page":"717","article-title":"Electron microscopy of carotid body hyperplasia","volume":"1984","author":"Jago, R.; Smith, P.; Heath, D.","unstructured":"Jago, R., Smith, P. & Heath, D. Electron microscopy of carotid body hyperplasia. Arch Pathol Lab Med 1984, 108: 717-722.","journal-title":"Arch Pathol Lab Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/65\/764\/353\/50076500\/postgradmedj-65-353.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/65\/764\/353\/50076500\/postgradmedj-65-353.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T10:37:29Z","timestamp":1683196649000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/65\/764\/353\/7138653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6,1]]},"references-count":17,"journal-issue":{"issue":"764","published-online":{"date-parts":[[1989,6,1]]},"published-print":{"date-parts":[[1989,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.65.764.353","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1989,6]]},"published":{"date-parts":[[1989,6,1]]}}}