{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:51:03Z","timestamp":1762865463165},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"765","license":[{"start":{"date-parts":[[1989,7,1]],"date-time":"1989-07-01T00:00:00Z","timestamp":615254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,7,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Because of its anti-androgenic activity spironolactone 50-200 mg daily is advocated widely for the management of female hirsutism but this practice lacks adequately controlled experimental support. In a double-blind placebo controlled study of the efficacy of spironolactone 100 mg daily in idiopathic hirsutism we were unable to demonstrate objective benefit from spironolactone treatment. The mean effect of spironolactone given over a 9 month period was to increase hair shaft diameter by +15% with 95% CI (-0.4% to +29%). In addition there were no changes in circulating serum androgen concentrations.<\/jats:p>","DOI":"10.1136\/pgmj.65.765.459","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"459-462","source":"Crossref","is-referenced-by-count":22,"title":["Lack of effect of spironolactone on hair shaft diameter in hirsute females"],"prefix":"10.1093","volume":"65","author":[{"given":"A R","family":"McLellan","sequence":"first","affiliation":[{"name":"University Department of Medicine, Western Infirmary , Glasgow G11 6NT , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Rentoul","sequence":"additional","affiliation":[{"name":"University Department of Dermatology, Western Infirmary , Glasgow G11 6NT , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"MacKie","sequence":"additional","affiliation":[{"name":"University Department of Dermatology, Western Infirmary , Glasgow G11 6NT , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G T","family":"McInnes","sequence":"additional","affiliation":[{"name":"University Department of Medicine, Western Infirmary , Glasgow G11 6NT , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1989,7,1]]},"reference":[{"key":"ref_1","article-title":"Type of Spironalactone Assessment hirsutism n Dose (mg\/day) Semi-objective Objective Control group included","unstructured":"Type of Spironalactone Assessment hirsutism n Dose (mg\/day) Semi-objective Objective Control group included Boisselle & Tremblay (1979)3 mixed 31"},{"key":"ref_2","article-title":"mixed 30 b Cumming","author":"Shapiro; Evron","year":"1980","unstructured":"Shapiro & Evron (1980)4 mixed 30 b Cumming et al. (1982)5 mixed 11 b","journal-title":"et al"},{"key":"ref_3","article-title":"mixed 21 a","author":"Nielsen","year":"1982","unstructured":"Nielsen (1982)6 mixed 21 a"},{"key":"ref_4","author":"Messina","year":"1983","unstructured":"Messina et al. (1983)"},{"key":"ref_5","author":"Milewicz","year":"1983","unstructured":"Milewicz et al. (1983)9"},{"key":"ref_6","first-page":"9","volume":"mixed","author":"Spandri","year":"1984","unstructured":"Spandri et al. (1984)10 mixed 9"},{"key":"ref_7","author":"Lobo","year":"1985","unstructured":"Lobo et al. (1985)"},{"key":"ref_8","first-page":"100","volume":"10","author":"Pittaway","year":"1985","unstructured":"Pittaway et al. (1985)12 mixed 10 100-150 a"},{"key":"ref_9","author":"Dorrington-Ward","year":"1985","unstructured":"Dorrington-Ward et al. (1985)'3 idiopathic 14 b"},{"key":"ref_10","author":"Evans; Burke","year":"1986","unstructured":"Evans & Burke (1986)'4 mixed 48 a,b"},{"key":"ref_11","year":"1986","unstructured":"Tremblay (1986)"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1210\/endo-97-6-1521","article-title":"Interaction of spironolactone and digitalis with the 5-dihydrotestosterone receptor of rat ventral prostate","volume":"97","author":"Pita, J.C.; Lipmann, M.E.; Thomson, E.B.; Loriaux, D.L.","year":"1975","unstructured":"Pita, J.C., Lipmann, M.E., Thomson, E.B. & Loriaux, D.L. Interaction of spironolactone and digitalis with the 5-dihydrotestosterone receptor of rat ventral prostate. Endocrinology 1975, 97: 1521-1527.","journal-title":"Endocrinology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1210\/endo-97-1-52","article-title":"Antiandrogenic effect of spironolactone: mechanism of action","volume":"97","author":"Corvol, P.; Michaud, A.; Menard, J.; Friefeld, M.; Mahoudean, J.","year":"1975","unstructured":"Corvol, P., Michaud, A., Menard, J., Friefeld, M. & Mahoudean, J. Antiandrogenic effect of spironolactone: mechanism of action. Endocrinology 1975, 97: 52-58.","journal-title":"Endocrinology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0015-0282(16)44232-9","article-title":"New therapeutic approach to the hirsute patient","volume":"32","author":"Boiselle, A.; Tremblay, R.R.","year":"1979","unstructured":"Boiselle, A. & Tremblay, R.R. New therapeutic approach to the hirsute patient. Fertil Steril 1979, 32: 276-279.","journal-title":"Fertil Steril"},{"issue":"51","key":"ref_15","first-page":"429","article-title":"A novel use of spironolactone: treatment ofhirsutism","volume":"1980","author":"Shapiro, G.; Evron, S.","unstructured":"Shapiro, G. & Evron, S. A novel use of spironolactone: treatment ofhirsutism. J Clin Endocrinol Metab 1980,51: 429-432.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/jama.1982.03320340049034","article-title":"Treatment of hirsutism with spironolactone","volume":"247","author":"Cumming, D.C.; Yang, J.C.; Rebar, R.W.; Yen, S.S.C.","year":"1982","unstructured":"Cumming, D.C., Yang, J.C., Rebar, R.W. & Yen, S.S.C. Treatment of hirsutism with spironolactone. JAMA 1982, 247: 1295-1298.","journal-title":"JAMA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000249940","article-title":"Treatment of idiopathic hirsutism with spironolactone","volume":"165","author":"Nielsen, P.G.","year":"1982","unstructured":"Nielsen, P.G. Treatment of idiopathic hirsutism with spironolactone. Dermatologica 1982, 165: 194-196.","journal-title":"Dermatologica"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF03350556","article-title":"Antiandrogenic properties of spironolactone. Clinical trial in the management of female hirsutism","volume":"6","author":"Messina, M.; Manieri, C.; Biffignandi, P.; Massucchetti, C.; Novi, R.F.; Molinatti, G.M.","year":"1983","unstructured":"Messina, M., Manieri, C., Biffignandi, P., Massucchetti, C., Novi, R.F. & Molinatti, G.M. Antiandrogenic properties of spironolactone. Clinical trial in the management of female hirsutism. J Endocrinol Invest 1983, 6: 23-27.","journal-title":"J Endocrinol Invest"},{"key":"ref_19","first-page":"393","article-title":"La spironolactone dans l'hirsutism idiopathique, evaluations clinique et biologique du traitement","volume":"44","author":"Abramovici, Y.; Guillet, F.; Matte, R.; Chaieb, L.; Belanger, R.","year":"1983","unstructured":"Abramovici, Y., Guillet, F., Matte, R., Chaieb, L. & Belanger, R. La spironolactone dans l'hirsutism idiopathique, evaluations clinique et biologique du traitement. Ann Endocrinol (Paris) 1983, 44: 393-396.","journal-title":"Ann Endocrinol (Paris)"},{"key":"ref_20","first-page":"429","article-title":"Therapeutic effects ofspironolactone in polycystic ovarian syndrome","volume":"61","author":"Milewicz, A.; Silber, D.; Kirchner, M.A.","year":"1983","unstructured":"Milewicz, A., Silber, D. & Kirchner, M.A. Therapeutic effects ofspironolactone in polycystic ovarian syndrome. 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Fertil Steril 1985, 43: 200-205.","journal-title":"Fertil Steril"},{"key":"ref_23","first-page":"43","article-title":"Spironolactone in combination drug therapy for unresponsive hirsutism","volume":"1985","author":"Pittaway, D.E.; Maxson, W.S.; Wentz, A.C.","unstructured":"Pittaway, D.E., Maxson, W.S. & Wentz, A.C. Spironolactone in combination drug therapy for unresponsive hirsutism. Fertil Steril 1985, 43: 878-882.","journal-title":"Fertil Steril"},{"issue":"23","key":"ref_24","first-page":"161","article-title":"The effect of spironolactone on hirsutism and female androgen metabolism","volume":"1985","author":"Dorrington-Ward, P.; McCartney, A.C.E.; Holland, S.","unstructured":"Dorrington-Ward, P., McCartney, A.C.E., Holland, S. et al. The effect of spironolactone on hirsutism and female androgen metabolism. Clin Endocrinol 1985, 23: 161-167.","journal-title":"Clin Endocrinol"},{"issue":"79","key":"ref_25","first-page":"451","article-title":"Spironolactone in the treatment of idiopathic hirsutism and the polycystic ovary syndrome","volume":"1986","author":"Evans, D.J.; Burke, C.W.","unstructured":"Evans, D.J. & Burke, C.W. Spironolactone in the treatment of idiopathic hirsutism and the polycystic ovary syndrome. J R Soc Med 1986, 79: 451-453.","journal-title":"J R Soc Med"},{"key":"ref_26","first-page":"363","article-title":"Treatment of hirsutism with spironolactone. Clin Endocrinol Metab","volume":"15","author":"Tremblay, R.R.","year":"1986","unstructured":"Tremblay, R.R. Treatment of hirsutism with spironolactone. Clin Endocrinol Metab 1986, 15: 363-371."},{"issue":"21","key":"ref_27","first-page":"1440","article-title":"Clinical assessment of body hair growth in women","volume":"1961","author":"Ferriman, D.; Gallwey, J.D.","unstructured":"Ferriman, D. & Gallwey, J.D. Clinical assessment of body hair growth in women. J Clin Endocrinol 1961, 21: 1440-1447.","journal-title":"J Clin Endocrinol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2133.1977.tb14244.x","article-title":"Effect of cyproterone acetate on hair growth, sebaceous secretion and endocrine parameters in a hirsute subject","volume":"97","author":"Ebling, F.J.; Thomas, A.K.; Cooke, I.D.; Randall, V.A.; Skinner, J.; Cawood, M.","year":"1977","unstructured":"Ebling, F.J., Thomas, A.K., Cooke, I.D., Randall, V.A., Skinner, J. & Cawood, M. Effect of cyproterone acetate on hair growth, sebaceous secretion and endocrine parameters in a hirsute subject. Br J Dermatol 1977, 97: 371-381.","journal-title":"Br J Dermatol"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1136\/adc.42.224.397","article-title":"Hair growth in kwashiorkor","volume":"42","author":"Sims, R.T.","year":"1967","unstructured":"Sims, R.T. Hair growth in kwashiorkor. Arch Dis Child 1967, 42: 397-400.","journal-title":"Arch Dis Child"},{"issue":"93","key":"ref_30","first-page":"119","article-title":"Hair growth measurement using intradermal sulphur 35 cystine","volume":"1966","author":"Munro, D.D.","unstructured":"Munro, D.D. Hair growth measurement using intradermal sulphur 35 cystine. Arch Dermatol 1966, 93: 119-122.","journal-title":"Arch Dermatol"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1365-2265.1976.tb03869.x","article-title":"Transplacental gradients of sex hormone binding globulin in human and simian pregnancy","volume":"5","author":"Anderson, D.C.; Lasley, B.L.; Fisher, R.A.; Shepherd, J.H.; Newman, L.; Hendricks, A.G.","year":"1976","unstructured":"Anderson, D.C., Lasley, B.L., Fisher, R.A., Shepherd, J.H., Newman, L. & Hendricks, A.G. Transplacental gradients of sex hormone binding globulin in human and simian pregnancy. 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