{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T23:06:59Z","timestamp":1757545619413},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"766","license":[{"start":{"date-parts":[[1989,8,1]],"date-time":"1989-08-01T00:00:00Z","timestamp":617932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Two cases of meningeal invasion by non-myelomatous plasma cell dyscrasias--a plasma cell leukaemia and an extramedullary plasmacytoma--are described. Both were secretors of IgD paraprotein and both were diagnosed in life, characteristics which we have not found in any other published case of plasma cell leptomeningitis. Analysis of our patients and of another 25 cases suggests as predisposing factors of meningeal invasion the male sex, presentation in the form of plasma cell leukaemia, presence of the IgD paraprotein and tumoral involvement of pleura, lung, pericardium and testicles.<\/jats:p>\n               <jats:p>Aggressive treatment of this neurological complication controlled the meningeal disorder in some cases. However, the majority died of disseminated disease in spite of systemic chemotherapy. Until an effective treatment can be found, able to maintain remission or cure the systemic disease, prophylaxis of the central nervous system in plasma cell dyscrasias does not appear to be advisable.<\/jats:p>","DOI":"10.1136\/pgmj.65.766.570","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"570-574","source":"Crossref","is-referenced-by-count":5,"title":["Meningeal infiltration by non-myelomatous IgD-secreting plasma cell dyscrasias"],"prefix":"10.1093","volume":"65","author":[{"given":"M","family":"Yebra","sequence":"first","affiliation":[{"name":"Servicio de Medicina Interna I, Cl\u00ednica Puerta de Hierro, Universidad Aut\u00f3noma de Madrid , San Martin de Porres, 4 28035 Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Manzano","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna I, Cl\u00ednica Puerta de Hierro, Universidad Aut\u00f3noma de Madrid , San Martin de Porres, 4 28035 Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"de la Torre","sequence":"additional","affiliation":[{"name":"Servicio de Radioterapia, Cl\u00ednica Puerta de Hierro, Universidad Aut\u00f3noma de Madrid , San Martin de Porres, 4 28035 Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hornedo","sequence":"additional","affiliation":[{"name":"Servicio de Radioterapia, Cl\u00ednica Puerta de Hierro, Universidad Aut\u00f3noma de Madrid , San Martin de Porres, 4 28035 Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Albarran","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna I, Cl\u00ednica Puerta de Hierro, Universidad Aut\u00f3noma de Madrid , San Martin de Porres, 4 28035 Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Men\u00e9ndez","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna I, Cl\u00ednica Puerta de Hierro, Universidad Aut\u00f3noma de Madrid , San Martin de Porres, 4 28035 Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1989,8,1]]},"reference":[{"key":"ref_1","first-page":"1753","article-title":"Plasma cell neoplasm","volume-title":"Cancer: Principles and Practice of Oncology","volume":"2","author":"Bergsagel, D.E.; Rider, W.D.","year":"1985","unstructured":"Bergsagel, D.E. & Rider, W.D. Plasma cell neoplasm. In: De Vita, T.V., Hellman, S. & Rosenberg, S.A. (eds) Cancer: Principles and Practice of Oncology, Vol. 2, 2nd edition. J.B. Lippincott, Philadelphia, 1985, pp. 1753-1795.","edition":"2nd edition"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/archinte.133.5.813","article-title":"Plasma cell leukemia: report on 17 cases","volume":"133","author":"Kyle, R.A.; Maldonado, J.E.; Bayrd, E.D.","year":"1974","unstructured":"Kyle, R.A., Maldonado, J.E. & Bayrd, E.D. Plasma cell leukemia: report on 17 cases. Arch Intern Med 1974, 133: 813-818.","journal-title":"Arch Intern Med"},{"key":"ref_3","first-page":"377","article-title":"Plasmocitoma extramedular IgD lambda simulando un adenoma de hip6fisis","volume":"79","author":"Hornedo, J.; Calvo, F.; Aramburu, P.","year":"1982","unstructured":"Hornedo, J., Calvo, F., Aramburu, P.. et al. Plasmocitoma extramedular IgD lambda simulando un adenoma de hip6fisis. 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Z Neurol 1972, 202: 229-240.","journal-title":"Z Neurol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/jcp.31.3.259","article-title":"Cerebral involvement in multiple myeloma: case report","volume":"31","author":"McCarthy, J.; Proctor, S.J.","year":"1978","unstructured":"McCarthy, J. & Proctor, S.J. Cerebral involvement in multiple myeloma: case report. J Clin Pathol 1978, 31: 259-264.","journal-title":"J Clin Pathol"},{"key":"ref_9","first-page":"680","article-title":"Leptomeningeal myeloma","volume":"103","author":"Slager, U.T.; Taylor, W.F.; Opfell, R.W.; Myers, A.","year":"1979","unstructured":"Slager, U.T., Taylor, W.F., Opfell, R.W. & Myers, A. Leptomeningeal myeloma. 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Cancer 1982, 49: 1710-1712.","journal-title":"Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/ajcp\/77.1.60","article-title":"IgD kappa plasma cell dyscrasies: extraosseous manifestations including isolated leptomeningitis","volume":"77","author":"Johnston, J.B.; Weinerman, B.; Cooney, T.; Bowman, D.M.; Pettigrew, N.M.; Orr, K.","year":"1982","unstructured":"Johnston, J.B., Weinerman, B., Cooney, T. & Bowman, D.M., Pettigrew, N.M. & Orr, K. IgD kappa plasma cell dyscrasies: extraosseous manifestations including isolated leptomeningitis. Am J Clin Pathol 1982, 77: 60-65.","journal-title":"Am J Clin Pathol"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/1097-0142(197909)44:3<1150::AID-CNCR2820440353>3.0.CO;2-U","article-title":"Pleural effusion in multiple myeloma","volume":"44","author":"Hughes, J.C.; Votaw, M.L.","year":"1979","unstructured":"Hughes, J.C. & Votaw, M.L. Pleural effusion in multiple myeloma. Cancer 1979, 44: 1150-1154.","journal-title":"Cancer"},{"key":"ref_16","first-page":"90","article-title":"Diagnostic cytology seminar","volume":"24","author":"Frable, W.J.; Bonfiglio, T.A.; Kaminsky, D.B.; Murphy, W.M.","year":"1980","unstructured":"Frable, W.J., Bonfiglio, T.A., Kaminsky, D.B. & Murphy, W.M. Diagnostic cytology seminar (case 7). Acta Cytol 1980, 24: 90-136.","journal-title":"Acta Cytol"},{"key":"ref_17","first-page":"117","article-title":"Meningite plasmocytaire au cours d'un myelome multiple. Observation anatomo-clinique","volume":"134","author":"Boudouresques, G.; Pellisier, J.F.; Gastaut, J.A.","year":"1983","unstructured":"Boudouresques, G., Pellisier, J.F., Gastaut, J.A. et al. Meningite plasmocytaire au cours d'un myelome multiple. Observation anatomo-clinique. 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