{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:13:37Z","timestamp":1758280417779},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"769","license":[{"start":{"date-parts":[[1989,11,1]],"date-time":"1989-11-01T00:00:00Z","timestamp":625881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 72 year old man developed acute organic brain syndrome associated with marked eosinophilia following self medication with a variety of drugs. Investigations revealed no other known causes of eosinophilia. Withdrawal of drugs resulted in dramatic drop in eosinophil count paralleled by clinical resolution of neurological problems. To our knowledge drug-induced eosinophilia has not previously been associated with acute organic brain syndrome.<\/jats:p>","DOI":"10.1136\/pgmj.65.769.843","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"843-844","source":"Crossref","is-referenced-by-count":1,"title":["Acute organic brain syndrome due to drug-induced eosinophilia"],"prefix":"10.1093","volume":"65","author":[{"given":"S C","family":"Ng","sequence":"first","affiliation":[{"name":"Haematology Division, Department of Pathology, University of Malaya , 59100 Kuala Lumpur , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M K","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical Faculty, University of Malaya , 59100 Kuala Lumpur , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Teh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical Faculty, University of Malaya , 59100 Kuala Lumpur , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1989,11,1]]},"reference":[{"issue":"521 -534","key":"ref_1","article-title":"Eosinophilia and allergic reactions to drugs","volume":"9","author":"Spry, C.J.F.","year":"1980","unstructured":"Spry, C.J.F. Eosinophilia and allergic reactions to drugs. Clin Haematol 1980, 9: 521 -534.","journal-title":"Clin Haematol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-197501000-00001","article-title":"The hypereosinophilic syndrome. Analysis of fourteen cases with review of the literature","volume":"54","author":"Chusid, M.J.; Dale, D.C.; West, B.C.; Wolff, S.M.","year":"1975","unstructured":"Chusid, M.J., Dale, D.C., West, B.C. & Wolff, S.M. The hypereosinophilic syndrome. Analysis of fourteen cases with review of the literature. Medicine 1975, 54: 1-27.","journal-title":"Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.7326\/0003-4819-97-1-78","article-title":"The idiopathic hypereosinophilic syndrome: clinical, pathophysiologic and therapeutic considerations","volume":"97","author":"Fauci, A.S.; Harley, J.B.; Roberts, W.C.; Ferrans, V.J.; Gralnick, H.R.; Bjornson, B.H.","year":"1982","unstructured":"Fauci, A.S., Harley, J.B., Roberts, W.C., Ferrans, V.J., Gralnick, H.R. & Bjornson, B.H. The idiopathic hypereosinophilic syndrome: clinical, pathophysiologic and therapeutic considerations. Ann Intern Med 1982, 97: 78-92.","journal-title":"Ann Intern Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1136\/bmj.2.6200.1262","article-title":"Tropical eosinophilia presenting with neurological features","volume":"79","author":"Ravindran, M.","year":"1979","unstructured":"Ravindran, M. Tropical eosinophilia presenting with neurological features. Br Med J 1979, 79: 1262.","journal-title":"Br Med J"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1073\/pnas.76.3.1443","volume":"76","author":"Durack, D.T.; Sumi, S.M.; Klebanoff, S.J.","year":"1979","unstructured":"Durack, D.T., Sumi, S.M. & Klebanoff, S.J. Neurotoxicity ofhuman eosinophils. Proc Natl Acad Sci USA 1979, 76: 1443-1447.","journal-title":"Neurotoxicity ofhuman eosinophils. Proc Natl Acad Sci USA"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/65\/769\/843\/50076582\/postgradmedj-65-843.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/65\/769\/843\/50076582\/postgradmedj-65-843.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T10:48:31Z","timestamp":1683197311000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/65\/769\/843\/7044493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11,1]]},"references-count":5,"journal-issue":{"issue":"769","published-online":{"date-parts":[[1989,11,1]]},"published-print":{"date-parts":[[1989,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.65.769.843","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1989,11]]},"published":{"date-parts":[[1989,11,1]]}}}