{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T22:11:14Z","timestamp":1771971074580,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"770","license":[{"start":{"date-parts":[[1989,12,1]],"date-time":"1989-12-01T00:00:00Z","timestamp":628473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Metabolic and toxicological data were obtained during the first 24 hours following severe and eventually fatal cyanide poisoning. Initial blood cyanide concentrations were 804 mumol\/l but fell rapidly over 24 hours following cobalt edetate therapy to 15 mumol\/l. However, plasma thiocyanate concentrations rose over 24 hours (147-267 mumol\/l) suggesting continued tissue detoxification. The major metabolic abnormality was lactic acidosis (initial pH 7.21, blood lactate 17.5 mmol\/l) which corrected over 12 hours. Despite high circulating insulin concentrations the responses of blood glucose, plasma non-esterified fatty acid, blood glycerol and 3-hydroxybutyrate suggested marked insulin resistance.<\/jats:p>","DOI":"10.1136\/pgmj.65.770.923","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"923-925","source":"Crossref","is-referenced-by-count":33,"title":["The metabolic effects of fatal cyanide poisoning"],"prefix":"10.1093","volume":"65","author":[{"given":"B M","family":"Singh","sequence":"first","affiliation":[{"name":"The General Hospital, Steelhouse Lane , Birmingham B4 6NH , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Coles","sequence":"additional","affiliation":[{"name":"The General Hospital, Steelhouse Lane , Birmingham B4 6NH , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Lewis","sequence":"additional","affiliation":[{"name":"The General Hospital, Steelhouse Lane , Birmingham B4 6NH , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Braithwaite","sequence":"additional","affiliation":[{"name":"Regional Laboratory for Toxicology, Dudley Road Hospital , Birmingham B18 7QH , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Nattrass","sequence":"additional","affiliation":[{"name":"The General Hospital, Steelhouse Lane , Birmingham B4 6NH , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M G","family":"FitzGerald","sequence":"additional","affiliation":[{"name":"The General Hospital, Steelhouse Lane , Birmingham B4 6NH , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1989,12,1]]},"reference":[{"issue":"294","key":"ref_1","first-page":"1325","article-title":"Successful cadaveric renal transplantation from a donor who died ofcyanide poisoning","volume":"1987","author":"Brown, P.W.G.; Buckles, J.A.C.; Jain, A.B.; McMaster, P.","unstructured":"Brown, P.W.G., Buckles, J.A.C., Jain, A.B. & McMaster, P. Successful cadaveric renal transplantation from a donor who died ofcyanide poisoning. Br MedJ 1987, 294: 1325.","journal-title":"Br MedJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1001\/archinte.1977.03630200055016","article-title":"Acute cyanide poisoning complicated by lactic acidosis and pulmonary oedema","volume":"137","author":"Graham, D.L.; Laman, D.; Theodore, J.; Robin, E.","year":"1977","unstructured":"Graham, D.L., Laman, D., Theodore, J. & Robin, E. Acute cyanide poisoning complicated by lactic acidosis and pulmonary oedema. Arch Int Med 1977, 137: 1051-1055.","journal-title":"Arch Int Med"},{"key":"ref_3","first-page":"239","article-title":"Phosphofructokinase","volume-title":"The Enzymes","volume":"8","author":"Bloxham, D.P.; Lardy, H.A.","year":"1973","unstructured":"Bloxham, D.P. & Lardy, H.A. Phosphofructokinase. In: Boyer, P.D. (ed.) The Enzymes, volume 8. Academic Press, New York, 1973, pp. 239-278."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2337\/diab.32.2.181","article-title":"Lactic acidosis revisited","volume":"32","author":"Cohen, R.D.; Woods, H.F.","year":"1983","unstructured":"Cohen, R.D. & Woods, H.F. Lactic acidosis revisited. Diabetes 1983, 32: 181-191.","journal-title":"Diabetes"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1432-1033.1979.tb04270.x","article-title":"Transport of D-lactate in perfused rat liver","volume":"102","author":"Schwab, A.J.; Bracht, A.; Scholz, R.","year":"1979","unstructured":"Schwab, A.J., Bracht, A. & Scholz, R. Transport of D-lactate in perfused rat liver. Eur J Biochem 1979, 102: 537-547.","journal-title":"Eur J Biochem"},{"issue":"33","key":"ref_6","first-page":"393","article-title":"Release of lactate by the liver in metabolic acidosis","volume":"1984","author":"Fine, A.; Brosnan, J.T.; Herzberg, G.R.","unstructured":"Fine, A., Brosnan, J.T. & Herzberg, G.R. Release of lactate by the liver in metabolic acidosis. Metabolism 1984, 33: 393-396.","journal-title":"Metabolism"},{"issue":"239","key":"ref_7","first-page":"245","article-title":"The content of NADH in rat skeletal muscle at rest and after cyanide poisoning","volume":"1986","author":"Sahlin, K.; Katz, A.","unstructured":"Sahlin, K. & Katz, A. The content of NADH in rat skeletal muscle at rest and after cyanide poisoning. Biochem J 1986, 239: 245-248.","journal-title":"Biochem J"},{"issue":"34","key":"ref_8","first-page":"1133","article-title":"Differences in insulin sensitivity between normal men and women","volume":"1985","author":"Hale, P.J.; Wright, J.V.; Nattrass, M.","unstructured":"Hale, P.J., Wright, J.V. & Nattrass, M. Differences in insulin sensitivity between normal men and women. Metabolism 1985, 34: 1133-1138.","journal-title":"Metabolism"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/65\/770\/923\/50076880\/postgradmedj-65-923.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/65\/770\/923\/50076880\/postgradmedj-65-923.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T16:06:52Z","timestamp":1682698012000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/65\/770\/923\/7044589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,12,1]]},"references-count":8,"journal-issue":{"issue":"770","published-online":{"date-parts":[[1989,12,1]]},"published-print":{"date-parts":[[1989,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.65.770.923","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1989,12]]},"published":{"date-parts":[[1989,12,1]]}}}