{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:28:03Z","timestamp":1772782083556,"version":"3.50.1"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"771","license":[{"start":{"date-parts":[[1990,1,1]],"date-time":"1990-01-01T00:00:00Z","timestamp":631152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A fatal case of acetonitrile ingestion is reported. The patient presented having apparently taken an overdose but was well until around 24 hours after the supposed ingestion, when cardiovascular collapse and profound metabolic acidosis developed. Later investigation revealed that the patient had taken acetone and acetonitrile. Acetone is known to slow the metabolism of acetonitrile to cyanide, thereby delaying the appearance of toxicity.<\/jats:p>","DOI":"10.1136\/pgmj.66.771.40","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"40-41","source":"Crossref","is-referenced-by-count":11,"title":["Acetonitrile ingestion: delayed onset of cyanide poisoning due to concurrent ingestion of acetone"],"prefix":"10.1093","volume":"66","author":[{"given":"M D","family":"Boggild","sequence":"first","affiliation":[{"name":"Department of Medicine, Leicester Royal Infirmary , Leicester LE2 7LX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R W","family":"Peck","sequence":"additional","affiliation":[{"name":"Department of Medicine, Leicester Royal Infirmary , Leicester LE2 7LX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C R V","family":"Tomson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Leicester Royal Infirmary , Leicester LE2 7LX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,1,1]]},"reference":[{"issue":"260","key":"ref_1","first-page":"3470","article-title":"Pediatric cyanide intoxication and death from an acetonitrile-containing cosmetic","volume":"1988","author":"Caravati, E.M.; Litovitz, T.L.","unstructured":"Caravati, E.M. & Litovitz, T.L. Pediatric cyanide intoxication and death from an acetonitrile-containing cosmetic. JAMA 1988, 260: 3470-3473.","journal-title":"JAMA"},{"key":"ref_2","first-page":"91","article-title":"Les intoxications par I'acetonitrile a propos d'un cas mortel","volume":"7","author":"Dequidt, J.; Furon, D.; Wattel, F.","year":"1974","unstructured":"Dequidt, J., Furon, D., Wattel, F. et al. Les intoxications par I'acetonitrile a propos d'un cas mortel. J Eur Toxicol 1974, 7: 91-97.","journal-title":"J Eur Toxicol"},{"issue":"1","key":"ref_3","first-page":"627","article-title":"Accidental group exposure to acetonitrile","volume":"1959","author":"Amdur, M.L.","unstructured":"Amdur, M.L. Accidental group exposure to acetonitrile. J Occup Med 1959, 1: 627-633.","journal-title":"J Occup Med"},{"issue":"18","key":"ref_4","first-page":"991","article-title":"Inhalation toxicology of acute exposure to aliphatic nitriles","volume":"1981","author":"Willhite, C.C.","unstructured":"Willhite, C.C. Inhalation toxicology of acute exposure to aliphatic nitriles. Clin Toxicol 1981, 18: 991-1003.","journal-title":"Clin Toxicol"},{"issue":"41","key":"ref_5","first-page":"340","article-title":"Acute voluntary intoxication by acetonitrile","volume":"1977","author":"Jaeger, A.; Tempe, J.D.; Porte, A.; Stoeckel, L.; Mantz, J.M.","unstructured":"Jaeger, A., Tempe, J.D., Porte, A., Stoeckel, L. & Mantz, J.M. Acute voluntary intoxication by acetonitrile. Acta Pharmacol Toxicol (Copenh) 1977, 41 (Suppl): 340.","journal-title":"Acta Pharmacol Toxicol (Copenh)"},{"issue":"15","key":"ref_6","first-page":"609","article-title":"Acetone potentiation of acute acetonitrile toxicity in rats","volume":"1985","author":"Freeman, J.J.; Hayes, E.P.","unstructured":"Freeman, J.J. & Hayes, E.P. Acetone potentiation of acute acetonitrile toxicity in rats. J Toxicol Environ Health 1985, 15: 609-621.","journal-title":"J Toxicol Environ Health"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/66\/771\/40\/50076922\/postgradmedj-66-40.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/66\/771\/40\/50076922\/postgradmedj-66-40.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T15:59:56Z","timestamp":1682697596000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/66\/771\/40\/7061994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1,1]]},"references-count":6,"journal-issue":{"issue":"771","published-online":{"date-parts":[[1990,1,1]]},"published-print":{"date-parts":[[1990,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.66.771.40","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1990,1]]},"published":{"date-parts":[[1990,1,1]]}}}