{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:44:37Z","timestamp":1770979477284,"version":"3.50.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"775","license":[{"start":{"date-parts":[[1990,5,1]],"date-time":"1990-05-01T00:00:00Z","timestamp":641520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The adverse effect of topical methylsalicylate ointment on warfarin anticoagulation is studied in 11 patients. All patients had an abnormally elevated international normalized ratio after significant usage of topical methylsalicylate ointment as obvious from both the clinical history and a positive blood level of salicylate. Out of the 11 patients, 3 had bleeding manifestation; 2 with bruises and 1 with gastrointestinal bleeding. It is concluded that topical methylsalicylate ointment should be prescribed with care to patients on warfarin and excessive usage is to be avoided since potentially dangerous drug interaction could occur.<\/jats:p>","DOI":"10.1136\/pgmj.66.775.367","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"367-369","source":"Crossref","is-referenced-by-count":41,"title":["Adverse effect of topical methylsalicylate ointment on warfarin anticoagulation: an unrecognized potential hazard"],"prefix":"10.1093","volume":"66","author":[{"given":"A S B","family":"Yip","sequence":"first","affiliation":[{"name":"Department of Medicine, Grantham Hospital , 125 Wong Chuk Hang Road, Aberdeen, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W H","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Medicine, Grantham Hospital , 125 Wong Chuk Hang Road, Aberdeen, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y T","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Grantham Hospital , 125 Wong Chuk Hang Road, Aberdeen, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K L","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Grantham Hospital , 125 Wong Chuk Hang Road, Aberdeen, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/014107688908200821","article-title":"Potentiation of warfarin anticoagulation by topical methylsalicylate ointment","volume":"82","author":"Chow, W.H.; Cheung, K.L.; Ling, H.M.; See, T.","year":"1989","unstructured":"Chow, W.H., Cheung, K.L., Ling, H.M. & See, T. Potentiation of warfarin anticoagulation by topical methylsalicylate ointment. J R Soc Med 1989, 82: 501-502.","journal-title":"J R Soc Med"},{"issue":"131","key":"ref_2","first-page":"857","article-title":"Combining NSAIDS with anticoagulants: yes and","volume":"1984","author":"O'Callaghan, J.W.; Thompson, R.N.; Russell, A.S.","unstructured":"O'Callaghan, J.W., Thompson, R.N. & Russell, A.S. Combining NSAIDS with anticoagulants: yes and no. Can Med Assoc J 1984, 131: 857-859.","journal-title":"no. Can Med Assoc J"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.0954-6820.1970.tb08058.x","article-title":"Salicylate-induced hypoprothrombinaemia","volume":"188","author":"Fausa, 0","year":"1970","unstructured":"Fausa, 0. Salicylate-induced hypoprothrombinaemia. Acta Med Scand 1970, 188: 403-408.","journal-title":"Acta Med Scand"},{"key":"ref_4","first-page":"236","article-title":"The Extra Pharmacopoeia","author":"Reynolds, J.E.FMartindale","year":"1982","unstructured":"Reynolds, J.E.F. (ed.). Martindale. The Extra Pharmacopoeia. The Pharmaceutical Press, London, 1982, p. 236."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1056\/NEJM197108262850905","article-title":"Drug interaction with coumarin antocoagulants (First of two parts)","volume":"285","author":"Koch-Weser, J.; Sellers, E.M.","year":"1971","unstructured":"Koch-Weser, J. & Sellers, E.M. Drug interaction with coumarin antocoagulants (First of two parts). N Engl J Med 1971, 285: 487-498.","journal-title":"N Engl J Med"},{"key":"ref_6","first-page":"204","article-title":"Aspirin and platelet aggregation","volume":"i:","author":"O'Brien, J.R.","unstructured":"O'Brien, J.R. Aspirin and platelet aggregation. Lancet 1968, i: 204-205.","journal-title":"Lancet 1968"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0140-6736(67)91658-3","article-title":"Impaired platelet\/connectivetissue reaction in man after aspirin ingestion","volume":"ii:","author":"Weiss, H.J.; Aledort, L.M.","year":"1967","unstructured":"Weiss, H.J. & Aledort, L.M. Impaired platelet\/connectivetissue reaction in man after aspirin ingestion. Lancet 1967, ii: 495-497.","journal-title":"Lancet"},{"issue":"4","key":"ref_8","first-page":"133","article-title":"Drug interactions in patients on long-term oral anticoagulant and antihypertensive adrenergic neurone-blocking drugs","volume":"1972","author":"Starr, K.J.; Petrie, J.C.","unstructured":"Starr, K.J. & Petrie, J.C. Drug interactions in patients on long-term oral anticoagulant and antihypertensive adrenergic neurone-blocking drugs. Br Med J 1972, 4: 133-135.","journal-title":"Br Med J"},{"key":"ref_9","first-page":"20","article-title":"Drug interference with warfarin therapy","volume":"77","author":"Udall, J.A.","year":"1970","unstructured":"Udall, J.A. Drug interference with warfarin therapy. Clin Med 1970, 77: 20-25.","journal-title":"Clin Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/66\/775\/367\/50077412\/postgradmedj-66-367.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/66\/775\/367\/50077412\/postgradmedj-66-367.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T15:08:09Z","timestamp":1682694489000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/66\/775\/367\/7062107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5,1]]},"references-count":9,"journal-issue":{"issue":"775","published-online":{"date-parts":[[1990,5,1]]},"published-print":{"date-parts":[[1990,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.66.775.367","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1990,5]]},"published":{"date-parts":[[1990,5,1]]}}}