{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T19:25:32Z","timestamp":1770492332941,"version":"3.49.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"775","license":[{"start":{"date-parts":[[1990,5,1]],"date-time":"1990-05-01T00:00:00Z","timestamp":641520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A kindred with Type I protein S deficiency is described in which the index case developed skin necrosis during induction of oral anticoagulant therapy for deep venous thrombosis. Two other family members with protein S deficiency have been detected, and demonstrate the clinical variability of this condition.<\/jats:p>","DOI":"10.1136\/pgmj.66.775.389","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"389-391","source":"Crossref","is-referenced-by-count":18,"title":["Type I protein S deficiency and skin necrosis"],"prefix":"10.1093","volume":"66","author":[{"given":"A","family":"Craig","sequence":"first","affiliation":[{"name":"Department of Haematology, Withington Hospital , Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Taberner","sequence":"additional","affiliation":[{"name":"Department of Haematology, Withington Hospital , Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A H","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Haematology, Withington Hospital , Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D N","family":"Foster","sequence":"additional","affiliation":[{"name":"Birch Hill Hospital , Rochdale, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Mitra","sequence":"additional","affiliation":[{"name":"Birch Hill Hospital , Rochdale, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,5,1]]},"reference":[{"key":"ref_1","first-page":"244","article-title":"Protein C and the development of skin necrosis during anticoagulant therapy","volume":"49","author":"Broekmans, A.W.; Bertina, R.M.; Loeliger, E.A.; Hofmann, V.; Klingemann, H.-G.","year":"1983","unstructured":"Broekmans, A.W., Bertina, R.M., Loeliger, E.A., Hofmann, V., & Klingemann, H-G. Protein C and the development of skin necrosis during anticoagulant therapy. (letter) Thromb Haemost 1983, 49: 244.","journal-title":"(letter) Thromb Haemost"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/bmj.298.6668.233","article-title":"Necrosis of skin induced by coumarin in a patient deficient in protein S","volume":"298","author":"Grimaudo, V.; Gueissaz, F.; Hauert, J.; Sarraj, A.; Kruithof, E.K.O.; Bachmann, F.","year":"1989","unstructured":"Grimaudo, V., Gueissaz, F., Hauert, J., Sarraj, A., Kruithof, E.K.O. & Bachmann, F. Necrosis of skin induced by coumarin in a patient deficient in protein S. Br Med J 1989, 298: 233-234.","journal-title":"Br Med J"},{"issue":"42","key":"ref_3","first-page":"257","article-title":"Protein C: a simplified semi-automated activity assay","volume":"1986","author":"Odegard, O.R.; Try, K.; Abildgaard, U.","unstructured":"Odegard, O.R., Try, K. & Abildgaard, U. Protein C: a simplified semi-automated activity assay. Thromb Res 1986, 42: 257-262.","journal-title":"Thromb Res"},{"issue":"67","key":"ref_4","first-page":"504","article-title":"An abnormal plasma distribution of protein S occurs in functional protein S deficiency","volume":"1986","author":"Comp, P.C.; Doray, D.; Patton, D.; Esmon, C.T.","unstructured":"Comp, P.C., Doray, D., Patton, D. & Esmon, C.T. An abnormal plasma distribution of protein S occurs in functional protein S deficiency. Blood 1986, 67: 504-508.","journal-title":"Blood"},{"key":"ref_5","first-page":"2","article-title":"Formation of the fibrin clot: The balance of procoagulant and inhibitory factors","volume-title":"Clinics in Haematology","volume":"14","author":"Lammle, B.; Griffin, J.H.","year":"1985","unstructured":"Lammle, B. & Griffin, J.H. Formation of the fibrin clot: The balance of procoagulant and inhibitory factors. In: Ruggeri, Z.M. (ed) Clinics in Haematology. W.B. Saunders, Philadelphia 1985, 14:2, 281-342."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1172\/JCI110385","article-title":"Deficiency of protein C in congenital thrombotic disease","volume":"68","author":"Griffin, J.H.; Evatt, B.; Zimmerman, T.S.; Kleiss, A.J.; Wideman, C.","year":"1981","unstructured":"Griffin, J.H., Evatt, B., Zimmerman, T.S., Kleiss, A.J. & Wideman, C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 1981, 68: 1370-1373.","journal-title":"J Clin Invest"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1056\/NEJM198412133112401","article-title":"Recurrent venous thromboembolism in patients with a partial deficiency of protein S","volume":"311","author":"Comp, P.C.; Esmon, C.T.","year":"1984","unstructured":"Comp, P.C. & Esmon, C.T. Recurrent venous thromboembolism in patients with a partial deficiency of protein S. N Engi J Med 1984, 311: 1525-1528.","journal-title":"N Engi J Med"},{"issue":"59","key":"ref_8","first-page":"18","article-title":"The frequency of Type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis","volume":"1988","author":"Gladson, C.L.; Scharrer, I.; Hach, V.; Beck, K.H.; Griffin, J.H.","unstructured":"Gladson, C.L., Scharrer, I., Hach, V., Beck, K.H. & Griffin, J.H. The frequency of Type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis. Thromb Haemost 1988, 59: 18-22.","journal-title":"Thromb Haemost"},{"issue":"45","key":"ref_9","first-page":"783","article-title":"Decline of proteins C & S and factors II VII IX and X during the intiation ofwarfarin therapy","volume":"1987","author":"Weiss, P.; Soff, G.A.; Halkin, H.; Seligsohn, U.","unstructured":"Weiss, P., Soff, G.A., Halkin, H. & Seligsohn, U. Decline of proteins C & S and factors II VII IX and X during the intiation ofwarfarin therapy. Thromb Res 1987,45:783-790.","journal-title":"Thromb Res"},{"key":"ref_10","first-page":"203","article-title":"Hereditary protein S deficiency","volume-title":"Protein C and Related Proteins","author":"Briet, E.; Broekmans, A.W.; Engesser, L.","year":"1988","unstructured":"Briet, E., Broekmans, A.W. & Engesser, L. Hereditary protein S deficiency. In: Bertina, R.M. (ed) Protein C and Related Proteins. Churchill Livingstone, Edinburgh, London, 1988, pp. 203-212."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/66\/775\/389\/50077058\/postgradmedj-66-389.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/66\/775\/389\/50077058\/postgradmedj-66-389.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T15:07:51Z","timestamp":1682694471000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/66\/775\/389\/7062105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5,1]]},"references-count":10,"journal-issue":{"issue":"775","published-online":{"date-parts":[[1990,5,1]]},"published-print":{"date-parts":[[1990,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.66.775.389","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1990,5]]},"published":{"date-parts":[[1990,5,1]]}}}