{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:23:57Z","timestamp":1760189037159},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"777","license":[{"start":{"date-parts":[[1990,7,1]],"date-time":"1990-07-01T00:00:00Z","timestamp":646790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,7,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Fasting and stimulated insulin concentrations in four patients with acanthosis nigricans and polycystic ovary syndrome were compared with four patients, matched for weight and ovarian morphology, without acanthosis. The median fasting serum insulin concentrations were 114.2 and 25.1 mU\/l in the respective groups (P = 0.02). One additional patient was investigated before and after an 18% increase in weight which resulted in a 170% increase in fasting insulin concentrations and the development of acanthosis nigricans. These observations suggest that there is variation between individuals in the degree of obesity that results in the development of acanthosis and that obese patients with this skin condition represent the severe end of the spectrum of the polycystic ovary syndrome.<\/jats:p>","DOI":"10.1136\/pgmj.66.777.536","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"536-538","source":"Crossref","is-referenced-by-count":15,"title":["Acanthosis nigricans in obese women with the polycystic ovary syndrome: disease spectrum not distinct entity"],"prefix":"10.1093","volume":"66","author":[{"given":"G S","family":"Conway","sequence":"first","affiliation":[{"name":"Cobbold Laboratories, The Middlesex Hospital , Mortimer Street, London W1N 8AA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H S","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Cobbold Laboratories, The Middlesex Hospital , Mortimer Street, London W1N 8AA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,7,1]]},"reference":[{"issue":"121","key":"ref_1","first-page":"193","article-title":"Metabolic importance of acanthosis nigricans","volume":"1985","author":"Flier, J.S.","unstructured":"Flier, J.S. Metabolic importance of acanthosis nigricans. Arch Dermatol 1985, 121: 193-194.","journal-title":"Arch Dermatol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0002-9343(87)90903-X","article-title":"Spectrum of endocrine abnormalities associated with acanthosis nigricans","volume":"83","author":"Matsuoka, L.Y.; Wortsman, J.; Gavin, J.R.; Goldman, J.","year":"1987","unstructured":"Matsuoka, L.Y., Wortsman, J., Gavin, J.R. & Goldman, J. Spectrum of endocrine abnormalities associated with acanthosis nigricans. Am J Med 1987, 83: 719-725.","journal-title":"Am J Med"},{"issue":"11","key":"ref_3","first-page":"500","article-title":"Selective insulin action on skin, ovary and heart in insulin resistant states","volume":"1988","author":"Geffner, M.E.; Golde, D.W.","unstructured":"Geffner, M.E. & Golde, D.W. Selective insulin action on skin, ovary and heart in insulin resistant states. Diabetes Care 1988, 11: 500-505.","journal-title":"Diabetes Care"},{"issue":"35","key":"ref_4","first-page":"197","article-title":"Insulin resistance with acanthosis nigricans: the roles of obesity and androgen excess","volume":"1986","author":"Stuart, C.A.; Peters, E.J.; Prince, M.J.; Richards, G.; Cavallo, A.; Meyer, W.J.","unstructured":"Stuart, C.A., Peters, E.J., Prince, M.J., Richards, G., Cavallo, A. & Meyer, W.J. Insulin resistance with acanthosis nigricans: the roles of obesity and androgen excess. Metabolism 1986, 35: 197-205.","journal-title":"Metabolism"},{"issue":"35","key":"ref_5","first-page":"807","article-title":"Acanthosis nigricans and obesity: acquired and intrinsic defects in insulin action","volume":"1986","author":"Peters, E.J.; Stuart, C.A.; Prince, M.J.","unstructured":"Peters, E.J., Stuart, C.A. & Prince, M.J. Acanthosis nigricans and obesity: acquired and intrinsic defects in insulin action. Metabolism 1986, 35: 807-813.","journal-title":"Metabolism"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1210\/jcem-57-2-356","article-title":"Insulin resistance in nonobese patients with polycystic ovarian disease","volume":"57","author":"Chang, R.J.; Nakamura, R.M.; Judd, H.L.; Kaplan, S.A.","year":"1983","unstructured":"Chang, R.J., Nakamura, R.M., Judd, H.L. & Kaplan, S.A. Insulin resistance in nonobese patients with polycystic ovarian disease. J Clin Endocrinol Metab 1983, 57: 356-359.","journal-title":"J Clin Endocrinol Metab"},{"issue":"120","key":"ref_7","first-page":"115","article-title":"Immunoassay of insulin: two antibody systems","volume":"1963","author":"Morgan, C.R.; Lazarow, A.","unstructured":"Morgan, C.R. & Lazarow, A. Immunoassay of insulin: two antibody systems. Diabetes 1963, 120: 115-126.","journal-title":"Diabetes"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1365-2265.1989.tb00446.x","article-title":"Heterogeneity of the polycystic ovary syndrome: clinical, endocrine and ultrasound features in 556 patients","volume":"30","author":"Conway, G.S.; Honour, J.W.; Jacobs, H.S.","year":"1989","unstructured":"Conway, G.S., Honour, J.W. & Jacobs, H.S. Heterogeneity of the polycystic ovary syndrome: clinical, endocrine and ultrasound features in 556 patients. Clin Endocrinol 1989, 30: 459-470.","journal-title":"Clin Endocrinol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1056\/NEJM197604012941401","article-title":"The syndromes of insulin resistance and acanthosis nigricans","volume":"294","author":"Kahn, C.R.; Flier, J.S.; Bar, R.S.","year":"1976","unstructured":"Kahn, C.R., Flier, J.S., Bar, R.S. et al. The syndromes of insulin resistance and acanthosis nigricans. N Engl J Med 1976, 294: 739-745.","journal-title":"N Engl J Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2265.1982.tb02632.x","article-title":"Acanthosis nigricans, hirsutism, insulin resistance and insulin receptor defect","volume":"17","author":"Leme, C.E.; Wajchenberg, B.L.; Lerario, A.C.; Goldman, J.; Borges, J.L.C.","year":"1982","unstructured":"Leme, C.E., Wajchenberg, B.L., Lerario, A.C., Goldman, J. & Borges, J.L.C. Acanthosis nigricans, hirsutism, insulin resistance and insulin receptor defect. Clin Endocrinol 1982, 17: 43-49.","journal-title":"Clin Endocrinol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1210\/jcem-47-3-620","article-title":"Insulin resistance, acanthosis nigricans, and normal insulin receptors in a young woman: evidence for a postreceptor defect","volume":"47","author":"Bar, R.S.; Muggeo, M.; Roth, J.; Kahn, C.R.; Havrankova, J.; lmperato-McGinley, J.","year":"1978","unstructured":"Bar, R.S., Muggeo, M., Roth, J., Kahn, C. R., Havrankova, J. & lmperato-McGinley, J. Insulin resistance, acanthosis nigricans, and normal insulin receptors in a young woman: evidence for a postreceptor defect. J Clin Endocrinol Metab 1978, 47: 620-625.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0002-9378(83)90091-1","article-title":"Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common endocrinopathy with distinct pathophysiologic features","volume":"147","author":"Barbieri, R.L.; Ryan, K.J.","year":"1983","unstructured":"Barbieri, R.L. & Ryan, K.J. Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common endocrinopathy with distinct pathophysiologic features. Am J Obstet Gynecol 1983, 147: 90-101.","journal-title":"Am J Obstet Gynecol"},{"issue":"50","key":"ref_13","first-page":"197","article-title":"The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism","volume":"1988","author":"Barbieri, R.L.; Smith, S.; Ryan, K.J.","unstructured":"Barbieri, R.L., Smith, S. & Ryan, K.J. The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism. Fertil Steril 1988, 50: 197-212.","journal-title":"Fertil Steril"},{"issue":"34","key":"ref_14","first-page":"101","article-title":"Acanthosis nigricans in obese women with hyperandrogenism. Characterization of an insulin-resistant state distinct from the type A and B syndromes","volume":"1985","author":"Flier, J.S.; Eastman, R.C.; Minaker, K.L.; Matteson, D.; Rowe, J.W.","unstructured":"Flier, J.S., Eastman, R.C., Minaker, K.L., Matteson, D. & Rowe, J.W. Acanthosis nigricans in obese women with hyperandrogenism. Characterization of an insulin-resistant state distinct from the type A and B syndromes. Diabetes 1985, 34: 101-107.","journal-title":"Diabetes"},{"issue":"35","key":"ref_15","first-page":"127","article-title":"Characterization of binding and phosphorylation defects of erythrocyte insulin receptors in the type A syndrome of insulin resistance","volume":"1986","author":"Grigorescu, F.; Flier, J.S.; Kahn, C.R.","unstructured":"Grigorescu, F., Flier, J.S. & Kahn, C.R. Characterization of binding and phosphorylation defects of erythrocyte insulin receptors in the type A syndrome of insulin resistance. Diabetes 1986, 35: 127-138.","journal-title":"Diabetes"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/66\/777\/536\/50077112\/postgradmedj-66-536.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/66\/777\/536\/50077112\/postgradmedj-66-536.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T14:18:49Z","timestamp":1682691529000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/66\/777\/536\/7061532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,7,1]]},"references-count":15,"journal-issue":{"issue":"777","published-online":{"date-parts":[[1990,7,1]]},"published-print":{"date-parts":[[1990,7,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.66.777.536","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1990,7]]},"published":{"date-parts":[[1990,7,1]]}}}