{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T21:33:19Z","timestamp":1753738399776},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"780","license":[{"start":{"date-parts":[[1990,10,1]],"date-time":"1990-10-01T00:00:00Z","timestamp":654739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Seven non-splenectomized patients with chronic refractory idiopathic thrombocytopenic purpura were treated with danazol 800 mg daily. All were glucocorticoid failures and four were refractory to all additional previous therapy. Five patients benefited from danazol and in two sustained normal platelet counts, for over 44 and 51 months, were observed. We conclude that danazol is useful for long term management of otherwise refractory idiopathic thrombocytopenic purpura. The advantage of danazol over splenectomy as a first line treatment in steroid failure is suggested.<\/jats:p>","DOI":"10.1136\/pgmj.66.780.827","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"827-830","source":"Crossref","is-referenced-by-count":11,"title":["Danazol in non-splenectomized patients with refractory idiopathic thrombocytopenic purpura"],"prefix":"10.1093","volume":"66","author":[{"given":"D Z","family":"Edelmann","sequence":"first","affiliation":[{"name":"Department of Hematology, The Edith Wolfson Medical Center , Holon 58100, Israel"},{"name":"Department of Medicine \u2018B\u2019, The Edith Wolfson Medical Center , Holon 58100, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Knobel","sequence":"additional","affiliation":[{"name":"Department of Medicine \u2018B\u2019, The Edith Wolfson Medical Center , Holon 58100, Israel"},{"name":"The Sackler Faculty of Medicine, Tel-Aviv University , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Virag","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Edith Wolfson Medical Center , Holon 58100, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Meytes","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Edith Wolfson Medical Center , Holon 58100, Israel"},{"name":"The Sackler Faculty of Medicine, Tel-Aviv University , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1056\/NEJM198105073041904","article-title":"Chronic idiopathic thrombocytopenic purpura","volume":"304","author":"McMillan, R.","year":"1981","unstructured":"McMillan, R. Chronic idiopathic thrombocytopenic purpura. N Engl J Med 1981, 304: 1135-1147.","journal-title":"N Engl J Med"},{"key":"ref_2","first-page":"75","article-title":"Generalized bleeding interpreting clinical findings. Hosp Pract","volume":"(IA):","author":"Harrington, W.J.","year":"1985","unstructured":"Harrington, W.J. Generalized bleeding interpreting clinical findings. Hosp Pract 1985, 20 (IA): 75-90."},{"issue":"61","key":"ref_3","first-page":"145","article-title":"The use of danazol in the management of chronic immune thrombocytopenic purpura","volume":"1985","author":"McVerry, B.A.; Auger, M.; Bellingham, A.J.","unstructured":"McVerry, B.A., Auger, M. & Bellingham, A.J. The use of danazol in the management of chronic immune thrombocytopenic purpura. Br J Haematol 1985, 61: 145-148.","journal-title":"Br J Haematol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1182\/blood.V56.3.329.329","article-title":"Autoimmune thrombocytopenic purpura","volume":"50","author":"Karpatkin, S.","year":"1980","unstructured":"Karpatkin, S. Autoimmune thrombocytopenic purpura. Blood 1980, 50: 329-343.","journal-title":"Blood"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev.me.28.020177.001503","article-title":"Treatment ofidiopathic thrombocytopenic purpura (ITP)","volume":"28","author":"Ahn, Y.S.; Harrington, W.J.","year":"1977","unstructured":"Ahn, Y.S. & Harrington, W.J. Treatment ofidiopathic thrombocytopenic purpura (ITP). Ann Rev Med 1977, 28: 299-309.","journal-title":"Ann Rev Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1056\/NEJM198306093082306","article-title":"Danazol for the treatment of idiopathic thrombocytopenic purpura","volume":"308","author":"Ahn, Y.S.; Harrington, W.J.; Simon, S.R.","year":"1983","unstructured":"Ahn, Y.S., Harrington, W.J., Simon, S.R. et al. Danazol for the treatment of idiopathic thrombocytopenic purpura. N Engl J Med 1983, 308: 1396-1399.","journal-title":"N Engl J Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"625","DOI":"10.7326\/0003-4819-96-5-625","volume":"96","author":"Madanes, A.E.; Farber, M.","year":"1982","unstructured":"Madanes, A.E. & Farber, M. Danazol. Ann Intern Med 1982, 96: 625-630.","journal-title":"Danazol. Ann Intern Med"},{"issue":"21","key":"ref_8","first-page":"418","article-title":"Use ofdanazol in the management of chronic idiopathic thrombocytopenic purpura","volume":"1985","author":"Heyd, J.; Hershko, C.","unstructured":"Heyd, J. & Hershko, C. Use ofdanazol in the management of chronic idiopathic thrombocytopenic purpura. Isr J Med Sci 1985, 21: 418-420.","journal-title":"Isr J Med Sci"},{"issue":"74","key":"ref_9","first-page":"97","article-title":"Danazol for the treatment of idiopathic thrombocytopenic purpura","volume":"1985","author":"Buelli, M.; Cortelazzo, S.; Viero, P.","unstructured":"Buelli, M., Cortelazzo, S., Viero, P. et al., Danazol for the treatment of idiopathic thrombocytopenic purpura. Acta Hematol (Basel) 1985, 74: 97-98.","journal-title":"Acta Hematol (Basel)"},{"issue":"74","key":"ref_10","first-page":"120","article-title":"Danazol in idiopathic thrombocytopenic purpura","volume":"1985","author":"Almagro, D.","unstructured":"Almagro, D. Danazol in idiopathic thrombocytopenic purpura. Acta Hematol (Basel) 1985, 74: 120.","journal-title":"Acta Hematol (Basel)"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1172\/JCI109838","article-title":"Danazolinduced augmentation of serum alpha I antitrypsin levels in individuals with marked deficiency ofthis antiprotease","volume":"66","author":"Gadek, J.E.; Fulmer, J.D.; Gelfand, J.A.","year":"1980","unstructured":"Gadek, J.E., Fulmer, J.D., Gelfand, J.A. et al., Danazolinduced augmentation of serum alpha I antitrypsin levels in individuals with marked deficiency ofthis antiprotease. J Clin Invest 1980, 66: 82-87.","journal-title":"J Clin Invest"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"809","DOI":"10.7326\/0003-4819-93-6-809","article-title":"Long-term therapy of hereditary angioedema with danazol","volume":"93","author":"Hosea, S.W.; Stantaella, M.L.; Brown, E.J.","year":"1980","unstructured":"Hosea, S.W., Stantaella, M.L., Brown, E.J. et al., Long-term therapy of hereditary angioedema with danazol. Ann Intern Med 1980, 93: 809-812.","journal-title":"Ann Intern Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1136\/bmj.284.6327.1431","article-title":"Systemic lupus erythematosus, two patients treated with danazol","volume":"284","author":"Morley, K.D.; Parke, A.; Hughes, G.R.V.","year":"1982","unstructured":"Morley, K.D., Parke, A. & Hughes, G.R.V. Systemic lupus erythematosus, two patients treated with danazol. 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Ann Intern Med 1988, 108: 703-706.","journal-title":"Ann Intern Med"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJM198702263160903","article-title":"Effect of danazol in immune thrombocytopenic purpura","volume":"316","author":"Schreiber, A.D.; Chien, P.; Tomaski, A.; Cines, D.B.","year":"1987","unstructured":"Schreiber, A.D., Chien, P., Tomaski, A. & Cines, D.B. Effect of danazol in immune thrombocytopenic purpura. N Engl J Med 1987, 316: 503-508.","journal-title":"N Engl J Med"},{"issue":"42","key":"ref_17","first-page":"281","article-title":"Immune modulation by danazol in autoimmune thrombocytopenia","volume":"1987","author":"Mylvaganam, R.; Ahn, Y.S.; Harrington, W.J.; Kim, C.J.","unstructured":"Mylvaganam, R., Ahn, Y.S., Harrington, W.J. & Kim, C.J. Immune modulation by danazol in autoimmune thrombocytopenia. Clin Immunol Immunopathol 1987,42:281-297.","journal-title":"Clin Immunol Immunopathol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/66\/780\/827\/50077522\/postgradmedj-66-827.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/66\/780\/827\/50077522\/postgradmedj-66-827.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T16:57:16Z","timestamp":1682614636000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/66\/780\/827\/7062244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10,1]]},"references-count":17,"journal-issue":{"issue":"780","published-online":{"date-parts":[[1990,10,1]]},"published-print":{"date-parts":[[1990,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.66.780.827","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1990,10]]},"published":{"date-parts":[[1990,10,1]]}}}