{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:20:08Z","timestamp":1757704808642},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"780","license":[{"start":{"date-parts":[[1990,10,1]],"date-time":"1990-10-01T00:00:00Z","timestamp":654739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Anticoagulation instability due to a change in intake of vitamin K after dietary modification was observed in 2 patients on long-term oral anticoagulants. One patient developed diffuse bruises treated conservatively with fresh frozen plasma transfusion and the other had a thrombosed aortic prosthesis which required emergency operation. To prevent such complications, dietary modification especially with food rich in vitamin K should be undertaken with care in patients on long-term oral anticoagulants.<\/jats:p>","DOI":"10.1136\/pgmj.66.780.855","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"855-857","source":"Crossref","is-referenced-by-count":24,"title":["Anticoagulation instability with life-threatening complication after dietary modification"],"prefix":"10.1093","volume":"66","author":[{"given":"W H","family":"Chow","sequence":"first","affiliation":[{"name":"Department of Medicine, The Grantham Hospital , 125 Wong Chuk Hang Road, Aberdeen, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T C","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Grantham Hospital , 125 Wong Chuk Hang Road, Aberdeen, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T M","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Grantham Hospital , 125 Wong Chuk Hang Road, Aberdeen, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y T","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Grantham Hospital , 125 Wong Chuk Hang Road, Aberdeen, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W T","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Grantham Hospital , 125 Wong Chuk Hang Road, Aberdeen, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,10,1]]},"reference":[{"issue":"141","key":"ref_1","first-page":"507","article-title":"Acquired warfarin resistance and weight-reducing diet","volume":"1981","author":"Qureshi, G.D.; Reinders, T.P.; Swint, J.J.","unstructured":"Qureshi, G.D., Reinders, T.P. & Swint, J.J. et al. Acquired warfarin resistance and weight-reducing diet. Arch Intern Med 1981, 141: 507-509.","journal-title":"Arch Intern Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1056\/NEJM198305193082016","article-title":"Warfarin resistance caused by broccoli","volume":"308","author":"Kempin, S.J.","year":"1983","unstructured":"Kempin, S.J. Warfarin resistance caused by broccoli. N EnglJ Med 1983, 308: 1229.","journal-title":"N EnglJ Med"},{"key":"ref_3","first-page":"170","article-title":"Modern Nutrition in Health and Disease. Lea and Febiger","author":"Olson, R.E.Vitamin K.","year":"1980","unstructured":"Olson, R.E. Vitamin K. In: Goodhart, R.S. & Shils, M.E. (eds) Modern Nutrition in Health and Disease. Lea and Febiger, Philadelphia, 1980, pp. 170-180."},{"key":"ref_4","first-page":"20","article-title":"Drug interference with warfarin therapy","volume":"77","author":"Udall, J.D.","year":"1970","unstructured":"Udall, J.D. Drug interference with warfarin therapy. Clin Med 1970, 77: 20-25.","journal-title":"Clin Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1136\/bmj.285.6347.1045-b","article-title":"Drug interaction with coumarin derivative anticoagulants","volume":"285","author":"Watson, P.G.; Lochan, R.G.; Redding, V.J.","year":"1982","unstructured":"Watson, P.G., Lochan, R.G. & Redding, V.J. Drug interaction with coumarin derivative anticoagulants. Br Med J 1982, 285: 1045-1046.","journal-title":"Br Med J"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/ajcn\/45.4.687","article-title":"Recommended dietary intakes (RDI) of vitamin","volume":"45","author":"Olson, J.A.","year":"1987","unstructured":"Olson, J.A. Recommended dietary intakes (RDI) of vitamin K in humans. Am J Clin Nutr 1987, 45: 687-692.","journal-title":"Am J Clin Nutr"},{"key":"ref_7","first-page":"2730","article-title":"dependent modifications of glutamic acid","volume-title":"residues in prothrombin. Proc Mol Acad Sci","volume":"71","author":"Stenflo, J.; Fennland, P.; Egan, W.; Roepstorff, P.Vitamin K.","year":"1974","unstructured":"Stenflo, J., Fennland, P., Egan, W. & Roepstorff, P. Vitamin K dependent modifications of glutamic acid residues in prothrombin. Proc Mol Acad Sci 1974, 71: 2730-2733."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1136\/jcp.30.12.1147","article-title":"Severe coagulation defect due to a dietary deficiency of vitamin K","volume":"30","author":"Colvin, B.T.; Lloyd, M.J.","year":"1977","unstructured":"Colvin, B.T. & Lloyd, M.J. Severe coagulation defect due to a dietary deficiency of vitamin K. J Clin Pathol 1977, 30: 1147-1148.","journal-title":"J Clin Pathol"},{"key":"ref_9","first-page":"803","article-title":"Dietary modification as cause of anticoagulation instability","volume":"ii:","author":"Kalra, P.A.; Cooklin, M.; Wood, G.; O'Shea, G.M.; Holmes, A.M.","year":"1988","unstructured":"Kalra, P.A., Cooklin, M., Wood, G., O'Shea, G.M. & Holmes, A.M. Dietary modification as cause of anticoagulation instability. Lancet 1988, ii: 803.","journal-title":"Lancet"},{"key":"ref_10","first-page":"171","article-title":"Inhibition of the hypoprothrombinemic effect of warfarin (Coumadin) by Ensure Plus, a dietary supplement","volume":"10","author":"Michaelson, R.; Kempin, S.J.; Navia, B.; Gold, J.W.M.","year":"1980","unstructured":"Michaelson, R., Kempin, S.J., Navia, B. & Gold, J.W.M. Inhibition of the hypoprothrombinemic effect of warfarin (Coumadin) by Ensure Plus, a dietary supplement. Clin Bull 1980, 10: 171-172.","journal-title":"Clin Bull"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1056\/NEJM198007173030317","article-title":"Resistance to warfarin due to unrecognized vitamin K supplementation","volume":"303","author":"O'Reilly, R.; Rytand, D.","year":"1980","unstructured":"O'Reilly, R. & Rytand, D. Resistance to warfarin due to unrecognized vitamin K supplementation. N Engl J Med 1980, 303: 160-161.","journal-title":"N Engl J Med"},{"key":"ref_12","first-page":"1871","article-title":"Do clotting factors in vitamin K-rich vegetables hinder anticoagulant therapy?","volume":"237","author":"Fletcher, D.C.","year":"1971","unstructured":"Fletcher, D.C. Do clotting factors in vitamin K-rich vegetables hinder anticoagulant therapy? JAMA 1971, 237: 1871.","journal-title":"JAMA"},{"issue":"220","key":"ref_13","first-page":"347","article-title":"On the influence of vitamin K-rich vegetables and wine on the effectiveness of warfarin treatment","volume":"1986","author":"Karlson, B.; Leijd, B.; Hellstrom, K.","unstructured":"Karlson, B., Leijd, B. & Hellstrom, K. On the influence of vitamin K-rich vegetables and wine on the effectiveness of warfarin treatment. 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