{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:29:00Z","timestamp":1775561340538,"version":"3.50.1"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"782","license":[{"start":{"date-parts":[[1990,12,1]],"date-time":"1990-12-01T00:00:00Z","timestamp":660009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Typhoid fever continues to escape swift diagnosis, even in an endemic country, and its multi-system nature led to delayed diagnosis in 25% of the patients in this study. This may have been an avoidable factor, leading to death in some patients through delay in instituting appropriate antimicrobial therapy. Neurological features and diarrhoea were particularly common in this paediatric population. Relative bradycardia has been shown to be a highly statistically significant finding for our group as a whole. Amoxycillin remains an effective and useful alternative to chloramphenicol. The mortality rate of 2.5% remains unchanged over the last 10 years. The relative inaccessibility to good primary health care, acceptable water supplies and sanitation that the black South African child encounters cannot be ruled out as a co-factor.<\/jats:p>","DOI":"10.1136\/pgmj.66.782.1032","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"1032-1036","source":"Crossref","is-referenced-by-count":9,"title":["A review of typhoid fever in South African black children"],"prefix":"10.1093","volume":"66","author":[{"given":"M E","family":"Ellis","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, King Faisal Specialist Hospital & Research Centre , PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Moosa","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Natal Medical School , Durban, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Hillier","sequence":"additional","affiliation":[{"name":"University of Manchester Medical School , Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,12,1]]},"reference":[{"key":"ref_1","first-page":"384","article-title":"In: Manson's Tropical DiseasesBailliere Tindall","author":"Manson-Bahr, T.E.C.; Apted, F.I.C.Salmonellosis","year":"1982","unstructured":"Manson-Bahr, T.E.C. & Apted, F.I.C. Salmonellosis. In: Manson's Tropical Diseases, 18th edition. Bailliere Tindall, Edinburgh, London, 1982, p. 384.","edition":"18"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1097\/00007611-197607000-00037","article-title":"Gastrointestinal phenomena in childhood typhoid fever","volume":"69","author":"Colon, A.R.","year":"1976","unstructured":"Colon, A.R. Gastrointestinal phenomena in childhood typhoid fever. South Med J 1976, 69: 914.","journal-title":"South Med J"},{"key":"ref_3","first-page":"662","article-title":"Typhoid fever","author":"Hornick, R.B.","year":"1983","unstructured":"Hornick, R.B. Typhoid fever. In: Hoeprich, L. (ed.) Infectious Disease, 3rd edition. Harper and Rowe, Philadelphia, 1983, pp. 662-673.","edition":"3rd edition","journal-title":"Harper and Rowe, Philadelphia; Infectious Disease"},{"issue":"214","key":"ref_4","first-page":"2192","article-title":"Diagnostic specificity of Widals reaction for typhoid fever","volume":"1970","author":"Reynolds, D.W.; Carpenter, R.L.; Simon, W.H.","unstructured":"Reynolds, D.W., Carpenter, R.L. & Simon, W.H. Diagnostic specificity of Widals reaction for typhoid fever. JAMA 1970, 214: 2192-2196.","journal-title":"JAMA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1136\/bmj.2.6043.1031","article-title":"Further experience with amoxycillin in typhoid fever in children","volume":"2","author":"Scragg, J.N.","year":"1976","unstructured":"Scragg, J.N. Further experience with amoxycillin in typhoid fever in children. Br Med J 1976, 2: 1031.","journal-title":"Br Med J"},{"key":"ref_6","first-page":"556","article-title":"Typhoid fever and its management with special reference to the disease in childhood","author":"Scragg, J.N.","year":"1976","unstructured":"Scragg, J.N. Typhoid fever and its management with special reference to the disease in childhood. S Afr J Hosp Med 1976, 556-561.","journal-title":"S Afr J Hosp Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/66\/782\/1032\/50077629\/postgradmedj-66-1032.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/66\/782\/1032\/50077629\/postgradmedj-66-1032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T16:55:23Z","timestamp":1682614523000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/66\/782\/1032\/7061495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12,1]]},"references-count":6,"journal-issue":{"issue":"782","published-online":{"date-parts":[[1990,12,1]]},"published-print":{"date-parts":[[1990,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.66.782.1032","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1990,12]]},"published":{"date-parts":[[1990,12,1]]}}}