{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T20:07:05Z","timestamp":1704830825618},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"784","license":[{"start":{"date-parts":[[1991,2,1]],"date-time":"1991-02-01T00:00:00Z","timestamp":665366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>While investigating the radiological appearances of globus pallidus calcification in an autopsy case, cortical-pia mater calcification was detected. There was no documentation of its existence in the literature of radiology, neurology and neuropathology. To establish its incidence and clinical significance, 20 consecutive autopsy brains (15 males, 5 females, age 32\u201373 years, mean age 56.7) were studied with high resolution radiography and histology. Clinical records, autopsy findings, in-life plain skull films and computed tomography of the brain (if available) were reviewed. Radiologically, the calcifications appeared as 1\u20132 mm irregular spots or tiny pin-point opacities in the pia mater and subcortical regions, either unilaterally or bilaterally in the frontal (15 cases), temporal (15), parietal (3) and occipital lobes (1). Similar calcification was detected in 1 of the 3 in-life computed tomographic scans available. Histologically, these cortical-pia mater calcifications were extracellular amorphous calcified masses of various sizes in necrotic neural tissue, frequently associated with microscopic haemorrhage and hypoxic neuronal changes in the adjacent brain tissue. Blood vessels in the region were not hyalinized or calcified. The occurrence was not related to age. Hospital stay was &amp;lt; 7 days in 14 and &amp;lt; 30 days in 2; 50% of patients died within 48 hours after admission. None of the patients had records of long term cytotoxic chemotherapy, radiotherapy or central nervous system infection. Two had stroke, one had cerebellar atrophy and one mild hypercalcaemia. The high incidence of calcifications in the temporal lobes, while asymptomatic, suggests that cortical calcification may be a pointer to the aetiology of idiopathic epilepsies in the elderly.<\/jats:p>","DOI":"10.1136\/pgmj.67.784.147","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"147-153","source":"Crossref","is-referenced-by-count":4,"title":["Asymptomatic cerebral calcification\u2014a previously unrecognized feature"],"prefix":"10.1093","volume":"67","author":[{"given":"M M","family":"Arnold","sequence":"first","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Kreel","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,2,1]]},"reference":[{"key":"ref_1","first-page":"499","article-title":"Calcium metabolism and heterotopic calcification","author":"Water, J.B.; Israel, M.S.","year":"1987","unstructured":"Water, J.B. & Israel, M.S. Calcium metabolism and heterotopic calcification. In: Water, J.B. & Israel, M.S. (eds) General Pathology. Churchill Livingstone, Edinburgh, 1987, p. 499.","journal-title":"General Pathology. Churchill Livingstone, Edinburgh"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2214\/ajr.122.1.52","article-title":"Cerebral calcification in childhood leukemia mimicking Sturge-Weber Syndrome","volume":"122","author":"Borns, P.F.; Rancier, L.F.","year":"1974","unstructured":"Borns, P.F. & Rancier, L.F. Cerebral calcification in childhood leukemia mimicking Sturge-Weber Syndrome. 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J Cancer Res Clin Oncol 1981, 102: 81-91.","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF00688063","article-title":"Characteristic residual neuropathological features of Japanese B encephalitis","volume":"38","author":"Ishii, T.; Matsushita, M.; Hamada, S.","year":"1977","unstructured":"Ishii, T., Matsushita, M. & Hamada, S. Characteristic residual neuropathological features of Japanese B encephalitis. Acta Neuropathol 1977, 38: 181-186.","journal-title":"Acta Neuropathol"},{"key":"ref_7","first-page":"87","article-title":"Familial occurrence of 'idiopathic' calcification of cerebral capillaries","volume":"30","author":"Bowman, M.S.","year":"1954","unstructured":"Bowman, M.S. Familial occurrence of 'idiopathic' calcification of cerebral capillaries. Am J Pathol 1954, 30: 87-97.","journal-title":"Am J Pathol"},{"issue":"5","key":"ref_8","first-page":"279","article-title":"Idiopathic nonarteriosclerotic calcification of cerebral vessels","volume":"1961","author":"Friede, R.L.; Magee, K.R.; Mich, A.A.; Mack, E.W.","unstructured":"Friede, R.L., Magee, K.R., Mich, A.A. & Mack, E.W. Idiopathic nonarteriosclerotic calcification of cerebral vessels. Arch Neurol 1961, 5: 279-286.","journal-title":"Arch Neurol"},{"issue":"45","key":"ref_9","first-page":"426","article-title":"Meningio-angiomatosis: a report of six cases with special references to the occurrence of neurofibrillary tangles","volume":"1986","author":"Halper, J.; Scheithauer, B.W.; Okazaki, H.; Laws, E.R.","unstructured":"Halper, J., Scheithauer, B.W., Okazaki, H. & Laws, E.R. Meningio-angiomatosis: a report of six cases with special references to the occurrence of neurofibrillary tangles. 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The epidemiology of epilepsy in Rochester, Minnesota, 1935 through 1967. Epilepsia 1975, 16: 1-66.","journal-title":"Epilepsia"},{"issue":"27","key":"ref_13","first-page":"458","article-title":"Etiology of seizures in the elderly","volume":"1986","author":"Luhdorf, K.; Jensen, L.K.; Plesner, A.","unstructured":"Luhdorf, K., Jensen, L.K. & Plesner, A. Etiology of seizures in the elderly. 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