{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:35:05Z","timestamp":1761561305299},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"784","license":[{"start":{"date-parts":[[1991,2,1]],"date-time":"1991-02-01T00:00:00Z","timestamp":665366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>In this article we report on the development, introduction, and maintenance of a policy to promote rational use of thrombolytic drugs by hospital doctors. The work was undertaken within the framework of the voluntarily operated Riverside East drugs guide (formulary) management system (FMS). The policy was introduced in October 1988 and revised in November 1989 to coincide with the launch of the new, expensive thrombolytic drugs, alteplase (rt-PA, Actilyse) in 1988 and antistreplase (APSAC, Eminase) in 1989. Streptokinase was recommended as the first-line drug for patients who had not received it within the last 6 months. The policy was communicated to all staff in meetings and a drugs guide bulletin and reinforced by ward pharmacists.<\/jats:p>\n               <jats:p>Results over a 15 month period show voluntary compliance by prescribers with the recommended policy. One hundred and seventy-four patients (22% cardiac admissions) presented with acute myocardial infarction. Of these 43 (25%) received streptokinase, the first-line recommended drug, 7 received alteplase and none received anistreplase. The savings in drug expenditure from using streptokinase rather than alteplase or anistreplase for the 15-month period of investigation were over pounds 27,000. This work represents an example of the effectiveness of the Riverside East FMS model in influencing prescribing behaviour.<\/jats:p>","DOI":"10.1136\/pgmj.67.784.165","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"165-169","source":"Crossref","is-referenced-by-count":3,"title":["Medical audit and formulary management: a policy for rational use of thrombolytic drugs"],"prefix":"10.1093","volume":"67","author":[{"given":"D J R","family":"Morgan","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics, Charing Cross and Westminster Medical School , 17 Page Street, London SW1P 2AP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A","family":"Sutters","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics, Charing Cross and Westminster Medical School , 17 Page Street, London SW1P 2AP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Pugh","sequence":"additional","affiliation":[{"name":"Academic Department of Cardiovascular Medicine, Charing Cross and Westminster Medical School , 17 Page Street, London SW1P 2AP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,2,1]]},"reference":[{"key":"ref_1","first-page":"246","article-title":"Peer group review of drugs and the way forward","volume":"244","author":"Sutters, C.A.","year":"1989","unstructured":"Sutters, C.A. Peer group review of drugs and the way forward. Pharm J 1989, 244: 246-248.","journal-title":"Pharm J"},{"key":"ref_2","first-page":"297","article-title":"Seventeen years' experience of a voluntarily based drug rationalisation programme in hospital","volume":"1988","author":"Baker, J.A.; Lant, A.F.; Sutters, C.A.","unstructured":"Baker, J.A., Lant, A.F. & Sutters, C.A. Seventeen years' experience of a voluntarily based drug rationalisation programme in hospital. Br Med J 1988, 297: 465-469.","journal-title":"Br Med J"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2710.1990.tb00357.x","article-title":"The management ofa hospital formulary","volume":"15","author":"Sutters, C.A.","year":"1990","unstructured":"Sutters, C.A. The management ofa hospital formulary. J Clin Pharm Therap 1990, 15: 59-77.","journal-title":"J Clin Pharm Therap"},{"key":"ref_4","first-page":"349","article-title":"ISIS-2 Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases ofsuspected acute myocardial infarction","volume":"Hi:","year":"1988","unstructured":"ISIS-2 Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases ofsuspected acute myocardial infarction. Lancet 1988, Hi: 349-360.","journal-title":"Lancet"},{"key":"ref_5","first-page":"545","article-title":"Effect of intravenous APSAC on mortality after acute myocardial infarction: preliminary report of a placebo-controlled clinical trial","volume":"ii:","author":"Group, A.I.M.S.Trial Study","year":"1988","unstructured":"AIMS Trial Study Group. Effect of intravenous APSAC on mortality after acute myocardial infarction: preliminary report of a placebo-controlled clinical trial. Lancet 1988, ii: 545-549.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0140-6736(88)92656-6","article-title":"Trial of tissue plasminogen activator for mortality reduction in acute myocardial infarction, Anglo-Scandinavian Study of Early Thrombolytics","volume":"is:","author":"Wilcox, R.G.; Olsson, C.G.; Skene, A.M.","year":"1988","unstructured":"Wilcox, R.G., Olsson, C.G., Skene, A.M. et al. Trial of tissue plasminogen activator for mortality reduction in acute myocardial infarction, Anglo-Scandinavian Study of Early Thrombolytics. (ASSET). Lancet 1988, is: 525-533.","journal-title":"(ASSET). Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1136\/bmj.300.6719.237","article-title":"Districts' use of thrombolytic agents","volume":"300","author":"Burrell, C.J.; Skehan, J.D.; Cowley, M.L.","year":"1990","unstructured":"Burrell, C.J., Skehan, J.D., Cowley, M.L. et al. Districts' use of thrombolytic agents. Br Med J 1990, 300: 237-238.","journal-title":"Br Med J"},{"issue":"19","key":"ref_8","first-page":"251","article-title":"Audit reviewed: does feedback on performance change clinical behaviour?","volume":"1985","author":"Mitchell, M.W.; Fowkes, F.G.R.","unstructured":"Mitchell, M.W. & Fowkes, F.G.R. Audit reviewed: does feedback on performance change clinical behaviour? J R Coil Physicians 1985, 19: 251-254.","journal-title":"J R Coil Physicians"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1177\/106002807300701102","article-title":"Prescribing habits of physicians: a review of studies on prescribing of drugs (parts 1-3)","volume":"7","author":"Miller, R.R.","year":"1987","unstructured":"Miller, R.R. Prescribing habits of physicians: a review of studies on prescribing of drugs (parts 1-3). Drug Intell Clin Pharm 1987, 7: 492-500.","journal-title":"Drug Intell Clin Pharm"},{"issue":"9","key":"ref_10","first-page":"1","article-title":"Social processes in physicians adoption of a new drug","volume":"1959","author":"Coleman, J.; Menzel, H.; Katz, E.","unstructured":"Coleman, J., Menzel, H. & Katz, E. Social processes in physicians adoption of a new drug. J Chron Dis 1959, 9: 1.","journal-title":"J Chron Dis"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1136\/bmj.1.6019.1198","article-title":"Continuing education in therapeutics; aids to discussions on prescribing","volume":"i:","author":"Herxheimer, A.; Twycross, R.","year":"1976","unstructured":"Herxheimer, A. & Twycross, R. Continuing education in therapeutics; aids to discussions on prescribing. Br Med J 1976, i: 1198-1199.","journal-title":"Br Med J"},{"key":"ref_12","first-page":"93","article-title":"Intervention strategies aimed at modifying prescribing behaviour","volume":"14","author":"Plumridge, R.J.","year":"1984","unstructured":"Plumridge, R.J. Intervention strategies aimed at modifying prescribing behaviour. Aust J Pharm 1984; 14: 93-100.","journal-title":"Aust J Pharm"},{"issue":"7","key":"ref_13","first-page":"4","article-title":"Assuring rational antibiotic use: the impact of a joint microbiology - pharmacy surveillance programme","volume":"1984","author":"Plumridge, R.J.; McGehie, D.B.","unstructured":"Plumridge, R.J. & McGehie, D.B. Assuring rational antibiotic use: the impact of a joint microbiology - pharmacy surveillance programme. Aust Health Rev 1984, 7: 4.","journal-title":"Aust Health Rev"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/784\/165\/50075211\/postgradmedj-67-165.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/784\/165\/50075211\/postgradmedj-67-165.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T16:17:26Z","timestamp":1682612246000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/67\/784\/165\/7061569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,2,1]]},"references-count":13,"journal-issue":{"issue":"784","published-online":{"date-parts":[[1991,2,1]]},"published-print":{"date-parts":[[1991,2,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.67.784.165","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1991,2]]},"published":{"date-parts":[[1991,2,1]]}}}