{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:25:24Z","timestamp":1773285924487,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"784","license":[{"start":{"date-parts":[[1991,2,1]],"date-time":"1991-02-01T00:00:00Z","timestamp":665366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We report a patient with fulminant Lassa fever who responded dramatically to a 2.5-litre exchange transfusion of whole blood. On admission he was semicomatose with facial oedema and oral haemorrhage; his platelets showed markedly depressed aggregation to ADP; and his plasma inhibited the aggregation responses of normal platelets in vitro. Exchange transfusion resulted in rapid clinical improvement, recovery of platelet function, and disappearance of platelet-inhibitory activity in plasma. The patient died 2 weeks later from an acute encephalopathy. His initial response was sufficiently impressive to suggest that further evaluation of this therapeutic approach is justified in selected patients with overwhelming Lassa virus infection.<\/jats:p>","DOI":"10.1136\/pgmj.67.784.193","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"193-194","source":"Crossref","is-referenced-by-count":11,"title":["Exchange transfusion of a patient with fulminant Lassa fever"],"prefix":"10.1093","volume":"67","author":[{"given":"D","family":"Cummins","sequence":"first","affiliation":[{"name":"Department of Haematology, University College and Middlesex School of Medicine , London, UK"},{"name":"Nixon Memorial Hospital and Lassa Fever Research Project , Sierra Leone , West Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Bennett","sequence":"additional","affiliation":[{"name":"Nixon Memorial Hospital and Lassa Fever Research Project , Sierra Leone , West Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S J","family":"Machin","sequence":"additional","affiliation":[{"name":"Department of Haematology, University College and Middlesex School of Medicine , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/infdis\/155.3.445","article-title":"A case-control study of the clinical diagnosis and course of Lassa fever","volume":"155","author":"McCormick, J.B.; King, I.J.; Webb, P.A.","year":"1987","unstructured":"McCormick, J.B., King, I.J., Webb, P.A. et al. A case-control study of the clinical diagnosis and course of Lassa fever. J Infect Dis 1987, 155: 445-455.","journal-title":"J Infect Dis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJM198601023140104","article-title":"Lassa fever: effective therapy with ribavarin","volume":"314","author":"McCormick, J.B.; King, I.J.; Webb, P.A.","year":"1986","unstructured":"McCormick, J.B., King, I.J., Webb, P.A. et al. Lassa fever: effective therapy with ribavarin. N Engl J Med 1986, 314: 20-26.","journal-title":"N Engl J Med"},{"key":"ref_3","first-page":"349","article-title":"Pathologic and virologic study of Lassa fever in man","volume":"107","author":"Walker, D.H.; McCormick, J.B.; Johnson, K.M.","year":"1982","unstructured":"Walker, D.H., McCormick, J.B., Johnson, K.M. et al. Pathologic and virologic study of Lassa fever in man. Am J Pathol 1982, 107: 349-356.","journal-title":"Am J Pathol"},{"key":"ref_4","first-page":"541","article-title":"A plasma inhibitor of platelet aggregation in patients with Lassa fever","volume":"72","author":"Cummins, D.; Fisher-Hoch, S.P.; Walshe, K.J.","year":"1989","unstructured":"Cummins, D., Fisher-Hoch, S.P., Walshe, K.J. et al. A plasma inhibitor of platelet aggregation in patients with Lassa fever. Br J Haematol 1989, 72: 541-548.","journal-title":"Br J Haematol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1365-2141.1989.tb00245.x","article-title":"Plasma from patients with severe Lassa fever profoundly modulates f-metleu-phe-induced superoxide generation in neutrophils","volume":"73","author":"Roberts, P.J.; Cummins, D.; Bainton, A.L.","year":"1989","unstructured":"Roberts, P.J., Cummins, D., Bainton, A.L. et al. Plasma from patients with severe Lassa fever profoundly modulates f-metleu-phe-induced superoxide generation in neutrophils. Br J Haematol 1989, 73: 152-157.","journal-title":"Br J Haematol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4269\/ajtmh.1970.19.677","article-title":"Report of a new virus disease of man from West Africa. II. Report of a laboratoryacquired infection treated with plasma from a person recently recovered from the disease","volume":"19","author":"Leifer, E.; Gocke, D.J.; Bourne, H.","year":"1970","unstructured":"Leifer, E., Gocke, D.J. & Bourne, H. Report of a new virus disease of man from West Africa. II. Report of a laboratoryacquired infection treated with plasma from a person recently recovered from the disease. Am J Trop Med Hyg 1970, 19: 677-679.","journal-title":"Am J Trop Med Hyg"},{"issue":"78","key":"ref_7","first-page":"319","article-title":"The use of Lassa fever convalescent plasma in Nigeria","volume":"1984","author":"Frame, J.D.; Verbrugge, G.P.; Gill, R.G.; Pinneo, L.","unstructured":"Frame, J.D., Verbrugge, G.P., Gill, R.G. & Pinneo, L. The use of Lassa fever convalescent plasma in Nigeria. Transcr R Soc Trop Med Hyg 1984, 78: 319-324.","journal-title":"Transcr R Soc Trop Med Hyg"},{"key":"ref_8","first-page":"1227","article-title":"Safe intensive-care management of a severe case of Lassa fever with simple barrier nursing techniques","volume":"ii:","author":"Fisher-Hoch, S.P.; Craven, R.B.; Forthall, D.N.","unstructured":"Fisher-Hoch, S.P., Craven, R.B., Forthall, D.N. et al. Safe intensive-care management of a severe case of Lassa fever with simple barrier nursing techniques. 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