{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:54:21Z","timestamp":1762001661002},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"786","license":[{"start":{"date-parts":[[1991,4,1]],"date-time":"1991-04-01T00:00:00Z","timestamp":670464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We report on 8 patients with giant lymph node hyperplasia (GLNH), diagnosed over a 10-year period. The age of the patients at diagnosis, the clinical presentation and the histological subtype varied, indicating that GNLH is a heterogeneous condition. One case was associated with liver cirrhosis, and in another patient bacterial endocarditis was diagnosed post mortem. Our study shows that GLNH is localized and benign in the young, and diffuse and aggressive in the elderly. It is concluded that GLNH should be separated into 3 clinical entities\u2014namely, localized, systemic and reactive GLNH\u2014defined by their clinical presentation and course, and correlated or not correlated with the histological findings.<\/jats:p>","DOI":"10.1136\/pgmj.67.786.366","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"366-370","source":"Crossref","is-referenced-by-count":12,"title":["Giant lymph node hyperplasia (Castleman's disease): a clinical study of eight patients"],"prefix":"10.1093","volume":"67","author":[{"given":"Y","family":"Baruch","sequence":"first","affiliation":[{"name":"Department of Internal Medicine B, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology , Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Ben-Arie","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology , Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Kerner","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology , Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Lorber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology , Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L-A","family":"Best","sequence":"additional","affiliation":[{"name":"Department of Chest Surgery, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology , Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Gershoni-Baruch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics A, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology , Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,4,1]]},"reference":[{"key":"ref_1","first-page":"26","article-title":"Case 40011 [hyperplasia of mediastinal lymph nodes]","volume":"250","author":"Castleman, B.","year":"1954","unstructured":"Castleman, B. Case 40011 [hyperplasia of mediastinal lymph nodes]. N Engl J Med 1954, 250: 26-30.","journal-title":"N Engl J Med"},{"issue":"9","key":"ref_2","first-page":"822","article-title":"Localized mediastinal lymph-node hyperplasia resembling thymoma","volume":"1956","author":"Castleman, B.; Iverson, L.; Menedex, V.","unstructured":"Castleman, B., Iverson, L. & Menedex, V. Localized mediastinal lymph-node hyperplasia resembling thymoma. Cancer 1956, 9: 822-830.","journal-title":"Cancer"},{"key":"ref_3","first-page":"296","article-title":"Benign giant lymphoma: clinicopathological correlation study","volume-title":"Year Book of Cancer","author":"Flendrig, J.A.","year":"1970","unstructured":"Flendrig, J.A. Benign giant lymphoma: clinicopathological correlation study. In: Clark, R.L. & Cumley, R.S. (eds) Year Book of Cancer. Year Book Medical Publishers, Chicago, 1970, pp. 296-299."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/1097-0142(197203)29:3<670::AID-CNCR2820290321>3.0.CO;2-#","article-title":"Hyalinevascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations","volume":"29","author":"Keller, A.R.; Hochholzer, L.; Castleman, B.","year":"1972","unstructured":"Keller, A.R., Hochholzer, L. & Castleman, B. Hyalinevascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer 1972, 29: 670-683.","journal-title":"Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00000478-198304000-00001","article-title":"A systemic lymphoproliferative disorder with morphologic features of Castleman's disease: pathological findings in 15 patients","volume":"7","author":"Frizzera, G.; Banks, P.M.; Massarelli, G.; Rosai, J.","year":"1983","unstructured":"Frizzera, G., Banks, P.M., Massarelli, G. & Rosai, J. A systemic lymphoproliferative disorder with morphologic features of Castleman's disease: pathological findings in 15 patients. Am J Surg Pathol 1983, 7: 211-231.","journal-title":"Am J Surg Pathol"},{"key":"ref_6","first-page":"129","author":"Joachim, H.L.Lymph Node Biopsy J.B.Lippincott; Philadelphia","year":"1982","unstructured":"Joachim, H.L. Lymph Node Biopsy. J.B. Lippincott, Philadelphia, 1982, pp. 129-137."},{"issue":"73","key":"ref_7","first-page":"423","article-title":"Multicentric giant lymph node hyperplasia: a hyperimmune syndrome with a rapidly progressive course","volume":"1980","author":"Bartoli, E.; Massarelli, G.; Soggia, G.; Tanda, F.","unstructured":"Bartoli, E., Massarelli, G., Soggia, G. & Tanda, F. Multicentric giant lymph node hyperplasia: a hyperimmune syndrome with a rapidly progressive course. Am J Clin Pathol 1980,73: 423-426.","journal-title":"Am J Clin Pathol"},{"issue":"16","key":"ref_8","first-page":"202","article-title":"Castleman's disease: more questions than answers","volume":"1985","author":"Frizzera, G.","unstructured":"Frizzera, G. Castleman's disease: more questions than answers. Hum Pathol 1985, 16: 202-205.","journal-title":"Hum Pathol"},{"key":"ref_9","first-page":"1053","article-title":"Multicentric giant lymph node hyperplasia: an immunohistochemical study","volume":"14","author":"Tanda, F.; Massarelli, G.; Costanzi, G.","year":"1983","unstructured":"Tanda, F., Massarelli, G. & Costanzi, G. Multicentric giant lymph node hyperplasia: an immunohistochemical study. Hwn Pathol 1983, 14: 1053-1059.","journal-title":"Hwn Pathol"},{"key":"ref_10","first-page":"317","article-title":"Mesenteric angiofollicular lymph node hyperplasia (lymphoid hamartoma) with nephrotic syndrome","volume-title":"Mayo Clin Proc 1975","volume":"50","author":"Humphreys, S.R.; Holley, R.E.; Smith, L.H.; McIlrath, D.C.","unstructured":"Humphreys, S.R., Holley, R.E., Smith, L.H. & McIlrath, D.C. Mesenteric angiofollicular lymph node hyperplasia (lymphoid hamartoma) with nephrotic syndrome. Mayo Clin Proc 1975, 50: 317-321."},{"key":"ref_11","first-page":"591","article-title":"Membranous nephropathy: its association with multicentric angiofollicular lymph node hyperplasia","volume":"103","author":"Weisenburger, D.","year":"1979","unstructured":"Weisenburger, D. Membranous nephropathy: its association with multicentric angiofollicular lymph node hyperplasia. Arch Pathol Lab Med 1979, 103: 591-594.","journal-title":"Arch Pathol Lab Med"},{"issue":"3","key":"ref_12","first-page":"1202","article-title":"A systemic lymphoproliferative disorder with morphologic features of Castleman's disease: clinical findings and clinicopathologic correlations in 15 patients","volume":"1985","author":"Frizzera, G.; Peterson, B.A.; Bayrd, E.D.; Goldman, A.","unstructured":"Frizzera, G., Peterson, B.A., Bayrd, E.D. & Goldman, A. A systemic lymphoproliferative disorder with morphologic features of Castleman's disease: clinical findings and clinicopathologic correlations in 15 patients. J Clin Oncol 1985, 3: 1202-1216.","journal-title":"J Clin Oncol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/ajcp\/91.3.344","article-title":"Giant lymph node hyperplasia of the hyaline-vascular type with plasma-cytoid T cells and presentation in infancy","volume":"91","author":"Hunt, S.J.; Anderson, W.D.","year":"1989","unstructured":"Hunt, S.J. & Anderson, W.D. Giant lymph node hyperplasia of the hyaline-vascular type with plasma-cytoid T cells and presentation in infancy. Am J Clin Pathol 1989, 91: 344-347.","journal-title":"Am J Clin Pathol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1136\/ard.48.4.326","article-title":"Multicentric Castleman's disease associated with rheumatoid arthritis: a possible role of hepatitis B antigen","volume":"48","author":"Ben Chetrit, E.; Flussef, D.; Okon, E.; Ackerman, Z.; Rubinow, A.","year":"1989","unstructured":"Ben Chetrit, E., Flussef, D., Okon, E., Ackerman, Z. & Rubinow, A. Multicentric Castleman's disease associated with rheumatoid arthritis: a possible role of hepatitis B antigen. Ann Rhewn Dis 1989, 48: 326-330.","journal-title":"Ann Rhewn Dis"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/00000478-198404000-00006","article-title":"Multicentric Castleman's disease and Kaposi's sarcoma","volume":"8","author":"Chen, K.T.K.","year":"1984","unstructured":"Chen, K.T.K. Multicentric Castleman's disease and Kaposi's sarcoma. Am J Surg Pathol 1984, 8: 287-293.","journal-title":"Am J Surg Pathol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/ajcp\/74.3.340","article-title":"Giant lymph node hyperplasia associated with thrombotic thrombocytopenic purpura","volume":"74","author":"Couch, W.D.","year":"1980","unstructured":"Couch, W.D. Giant lymph node hyperplasia associated with thrombotic thrombocytopenic purpura. Am J Clin Pathol 1980, 74: 340-344.","journal-title":"Am J Clin Pathol"},{"issue":"83","key":"ref_17","first-page":"27","article-title":"Castleman's disease followed by Kaposi sarcoma in two homosexual males with AIDS","volume":"1985","author":"Lachant, N.; Sun, N.; Leong, L.; Oseas, R.; Prince, H.","unstructured":"Lachant, N., Sun, N., Leong, L., Oseas, R. & Prince, H. Castleman's disease followed by Kaposi sarcoma in two homosexual males with AIDS. Am J Clin Pathol 1985, 83: 27-33.","journal-title":"Am J Clin Pathol"},{"issue":"16","key":"ref_18","first-page":"162","article-title":"Multicentric angiofollicular lymph node hyperplasia: a clinicopathological study of 16 cases","volume":"1985","author":"Weisenburger, D.; Nathwani, B.; Winberg, C.; Rappaport, H.","unstructured":"Weisenburger, D., Nathwani, B., Winberg, C. & Rappaport, H. Multicentric angiofollicular lymph node hyperplasia: a clinicopathological study of 16 cases. Hum Pathol 1985, 16: 162-172.","journal-title":"Hum Pathol"},{"issue":"24","key":"ref_19","first-page":"243","article-title":"Follicular hyperplasia in lymph nodes from patients with rheumatoid arthritis: a clinicopathologic study","volume":"1969","author":"Nosanchuk, J.S.; Schnitzer, B.","unstructured":"Nosanchuk, J.S. & Schnitzer, B. Follicular hyperplasia in lymph nodes from patients with rheumatoid arthritis: a clinicopathologic study. Cancer 1969, 24: 243-254.","journal-title":"Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/1097-0142(197301)31:1<241::AID-CNCR2820310132>3.0.CO;2-T","article-title":"Extrathoracic angiofollicular lymphoid hyperplasia with coincidental myasthenia gravis","volume":"31","author":"Emson, H.E.","year":"1973","unstructured":"Emson, H.E., Extrathoracic angiofollicular lymphoid hyperplasia with coincidental myasthenia gravis. Cancer 1973, 31: 241-245.","journal-title":"Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1056\/NEJM196504152721502","article-title":"Refractory anemia with abnormal iron metabolism: its remission after resection of hyperplastic mediastinal lymph nodes","volume":"272","author":"Lee, S.L.; Rosner, F.; Rivero, I.; Feldman, F.; Hurwitz, A.","year":"1965","unstructured":"Lee, S.L., Rosner, F., Rivero, I., Feldman, F. & Hurwitz, A. Refractory anemia with abnormal iron metabolism: its remission after resection of hyperplastic mediastinal lymph nodes. N Engl J Med 1965, 272: 761-766.","journal-title":"N Engl J Med"},{"key":"ref_22","first-page":"542","article-title":"Intraabdominal angiofollicular lymph node hyperplasia (plasma cell variant) with an antierythropoietic","volume-title":"factor. Mayo Clin Proc 1975","volume":"50","unstructured":"Burgert, E.O. Jr, Gilchrist, G.S., Fairbanks, V.F., Lynn, H.B., Dukes, P.P. & Harrison, E.G. Intraabdominal angiofollicular lymph node hyperplasia (plasma cell variant) with an antierythropoietic factor. Mayo Clin Proc 1975, 50: 542-546."},{"key":"ref_23","first-page":"566","article-title":"Gastric Castleman's disease with a lupus-like circulating antiocoagulant","volume":"84","author":"Yebra, M.; Vargas, J.A.; Menendez, M.J.","year":"1989","unstructured":"Yebra, M., Vargas, J.A., Menendez, M.J. et al. Gastric Castleman's disease with a lupus-like circulating antiocoagulant. Am J Gastroenterol 1989, 84: 566-569.","journal-title":"Am J Gastroenterol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/786\/366\/50075579\/postgradmedj-67-366.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/786\/366\/50075579\/postgradmedj-67-366.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T16:24:03Z","timestamp":1682612643000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/67\/786\/366\/7061652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,4,1]]},"references-count":23,"journal-issue":{"issue":"786","published-online":{"date-parts":[[1991,4,1]]},"published-print":{"date-parts":[[1991,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.67.786.366","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1991,4]]},"published":{"date-parts":[[1991,4,1]]}}}