{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:36:40Z","timestamp":1780504600325,"version":"3.54.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"786","license":[{"start":{"date-parts":[[1991,4,1]],"date-time":"1991-04-01T00:00:00Z","timestamp":670464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We describe a 14 year old boy with antiphospholipid syndrome who initially presented at the age of 10 with recurrent loin pain, fever, weight loss, leucocytosis, thrombocytopenia, hypertension and haematuria. He had primary adrenal insufficiency with bilaterally enlarged adrenals on computed tomographic (CT) scan consistent with adrenal infarction. Renal and liver biopsies showed microthrombi in the glomerular capillaries and hepatic sinusoids respectively. The case is unusual in that hypertension rather than hypotension was dominant and a CT scan was consistent with bilateral adrenal infarction without haemorrhage. He represented with evidence of persistent hypertension with glomerulosclerosis and glomerular microthrombi on repeat renal biopsy. He continues to have permanent adrenal insufficiency with complete atrophy of his adrenals.<\/jats:p>","DOI":"10.1136\/pgmj.67.786.385","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"385-388","source":"Crossref","is-referenced-by-count":39,"title":["Addison's disease, hypertension, renal and hepatic microthrombosis in \u2018primary\u2019 antiphospholipid syndrome"],"prefix":"10.1093","volume":"67","author":[{"given":"S","family":"Inam","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Riyadh Armed Forces Hospital , Riyadh, Saudia Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Sidki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Riyadh Armed Forces Hospital , Riyadh, Saudia Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A R","family":"al-Marshedy","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Riyadh Armed Forces Hospital , Riyadh, Saudia Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Judzewitsch","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Riyadh Armed Forces Hospital , Riyadh, Saudia Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1991,4,1]]},"reference":[{"issue":"39","key":"ref_1","first-page":"261","article-title":"Antiphospholipid antibodies-autoantibodies with a difference","volume":"1988","author":"Harris, E.N.; Asherson, R.A.; Hughes, G.R.V.","unstructured":"Harris, E.N., Asherson, R.A. & Hughes, G.R.V. Antiphospholipid antibodies-autoantibodies with a difference. Ann Rev Med 1988, 39: 261-271.","journal-title":"Ann Rev Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/bmj.287.6399.1088","article-title":"Thrombosis, abortion, cerebral disease and the lupus anticoagulant","volume":"287","author":"Hughes, G.R.V.","year":"1983","unstructured":"Hughes, G.R.V. Thrombosis, abortion, cerebral disease and the lupus anticoagulant. Br Med J 1983, 287: 1088-1089.","journal-title":"Br Med J"},{"issue":"62","key":"ref_3","first-page":"1081","article-title":"Anticardiolipin antibodies: clinical associations","volume":"1986","author":"Asherson, R.A.; Harris, E.N.","unstructured":"Asherson, R.A. & Harris, E.N. Anticardiolipin antibodies: clinical associations. Postgrad Med J 1986, 62: 1081-1087.","journal-title":"Postgrad Med J"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/014107688708000716","article-title":"Antiphospholipid antibody syndrome: a review","volume":"80","author":"Bingley, P.J.; Hofibrand, B.I.","year":"1987","unstructured":"Bingley, P.J. & Hofibrand, B.I. Antiphospholipid antibody syndrome: a review. J R Soc Med 1987, 80: 445-448.","journal-title":"J R Soc Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1136\/ard.48.5.355","article-title":"Antiphospholipid syndrome: linking many specialties","volume":"48","author":"Hughes, G.R.V.; Asherson, R.A.; Khamashta, M.A.","year":"1989","unstructured":"Hughes, G.R.V., Asherson, R.A. & Khamashta, M.A. Antiphospholipid syndrome: linking many specialties. 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