{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:21Z","timestamp":1761058881728},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"787","license":[{"start":{"date-parts":[[1991,5,1]],"date-time":"1991-05-01T00:00:00Z","timestamp":673056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Gastrointestinal disease is a well recognized feature in patients with common variable immunodeficiency, and is often due to infection with a variety of organisms. Symptoms usually improve with appropriate antibiotic therapy and replacement gammaglobulin. We describe three middle-aged female patients with common variable immunodeficiency who had protracted diarrhoea and weight loss. Despite extensive investigation no infectious cause was found.<\/jats:p>\n               <jats:p>All patients had granulomas distributed throughout the gastrointestinal tract, but no features of inflammatory bowel disease. There was a poor response to gammaglobulin replacement therapy, antibiotics or symptomatic treatment. We suggest that granulomatous enteropathy is another gastrointestinal manifestation of common variable immunodeficiency.<\/jats:p>","DOI":"10.1136\/pgmj.67.787.446","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"446-449","source":"Crossref","is-referenced-by-count":12,"title":["Granulomatous enteropathy in common variable immunodeficiency: a cause of chronic diarrhoea"],"prefix":"10.1093","volume":"67","author":[{"given":"N","family":"Mike","sequence":"first","affiliation":[{"name":"Departments of Gastroenterology, Immunology and Histopathology, East Birmingham Hospital , Bordesley Green East, Birmingham B9 5ST, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T T","family":"Hansel","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology, Immunology and Histopathology, East Birmingham Hospital , Bordesley Green East, Birmingham B9 5ST, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Newman","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology, Immunology and Histopathology, East Birmingham Hospital , Bordesley Green East, Birmingham B9 5ST, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Asquith","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology, Immunology and Histopathology, East Birmingham Hospital , Bordesley Green East, Birmingham B9 5ST, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,5,1]]},"reference":[{"key":"ref_1","first-page":"61","article-title":"Gastrointestinal tract in hypogammaglobulinaemia. 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Am J Med 1976, 61: 221-237.","journal-title":"Am J Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00005792-197305000-00004","article-title":"Structure and function of the gastrointestinal tract in primary immunodeficiency syndrome; a study of 39 patients","volume":"53","author":"Ament, M.E.; Ochs, H.D.; Davis, S.D.","year":"1973","unstructured":"Ament, M.E., Ochs, H.D. & Davis, S.D. Structure and function of the gastrointestinal tract in primary immunodeficiency syndrome; a study of 39 patients. Medicine 1973, 53: 227-248.","journal-title":"Medicine"},{"issue":"71","key":"ref_9","first-page":"581","article-title":"Regional enteritis","volume":"1969","author":"Eggert, R.C.; Wilson, I.D.; Good, R.A.","unstructured":"Eggert, R.C., Wilson, I.D. & Good, R.A. Regional enteritis. 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Dis Colon Rectum 1982, 25: 723-727.","journal-title":"Dis Colon Rectum"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/787\/446\/50075307\/postgradmedj-67-446.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/787\/446\/50075307\/postgradmedj-67-446.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T16:23:07Z","timestamp":1682612587000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/67\/787\/446\/7061779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,5,1]]},"references-count":23,"journal-issue":{"issue":"787","published-online":{"date-parts":[[1991,5,1]]},"published-print":{"date-parts":[[1991,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.67.787.446","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1991,5]]},"published":{"date-parts":[[1991,5,1]]}}}