{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T14:01:29Z","timestamp":1698501689873},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"788","license":[{"start":{"date-parts":[[1991,6,1]],"date-time":"1991-06-01T00:00:00Z","timestamp":675734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The efficacy and safety of fluconazole in the treatment of oesophageal candidiasis in patients with the acquired immunodeficiency syndrome (AIDS) was assessed in 36 patients. Fluconazole, 200 mg orally, was given on the first day, followed by 100 mg daily for 4 weeks. Clinical and mycological evaluation was performed in 31 patients at the end of treatment and 24 were also assessed after 8 weeks of starting treatment. In 1 patient fluconazole was discontinued, 5 patients were lost to follow-up and 6 patients died during the study.<\/jats:p>\n               <jats:p>Clinical and mycological cure was achieved in all patients; in 31 of 36 patients the clinical picture resolved within a week. The cure was confirmed in 27 patients by oesophagoscopy. Two patients relapsed 1 month after stopping fluconazole but the reinstitution of therapy achieved cure. Asymptomatic fungal oropharynx colonization was evident in about 40% of patients during treatment and follow-up period. Fluconazole was well tolerated by all patients but mild to moderate increase of liver enzymes values occurred in 16. Treatment had to be discontinued in 1 patient with hepatic tuberculosis because of severe liver function abnormalities, but their relation with the drug was uncertain.<\/jats:p>\n               <jats:p>Fluconazole is an effective and safe treatment of oesophageal candidiasis in AIDS patients.<\/jats:p>","DOI":"10.1136\/pgmj.67.788.548","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"548-552","source":"Crossref","is-referenced-by-count":9,"title":["Safety and efficacy of fluconazole treatment for Candida oesophagitis in AIDS"],"prefix":"10.1093","volume":"67","author":[{"given":"A","family":"Gil","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, La Paz Hospital, Universidad Aut\u00f3noma , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Lavilla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, La Paz Hospital, Universidad Aut\u00f3noma , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Valencia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, La Paz Hospital, Universidad Aut\u00f3noma , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Pintado","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, La Paz Hospital, Universidad Aut\u00f3noma , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L","family":"Dupla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, La Paz Hospital, Universidad Aut\u00f3noma , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Khamashta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, La Paz Hospital, Universidad Aut\u00f3noma , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Garc\u00eda-Puig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, La Paz Hospital, Universidad Aut\u00f3noma , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Ortiz-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, La Paz Hospital, Universidad Aut\u00f3noma , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1056\/NEJM198408093110602","article-title":"Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome","volume":"311","author":"Klein, R.S.; Harris, C.A.; Small, C.B.","year":"1984","unstructured":"Klein, R.S., Harris, C.A., Small, C.B. et al. Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. N Engl J Med 1984, 311: 354-358.","journal-title":"N Engl J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2165\/00003495-198733010-00004","article-title":"Management of infectious and immunological complications of acquired immunodeficiency syndrome (AIDS). Current and future prospects","volume":"33","author":"Tuazon, C.U.; Labriola, A.M.","year":"1987","unstructured":"Tuazon, C.U. & Labriola, A.M. Management of infectious and immunological complications of acquired immunodeficiency syndrome (AIDS). Current and future prospects. Drugs 1987, 33: 66-84.","journal-title":"Drugs"},{"key":"ref_3","first-page":"261","article-title":"Ketoconazole treatment of Candida esophagitis - a prospective study of 12 cases","volume":"78","author":"Fazio, R.A.; Wickremesinghe, P.C.; Arsura, E.L.","year":"1983","unstructured":"Fazio, R.A., Wickremesinghe, P.C. & Arsura, E.L. Ketoconazole treatment of Candida esophagitis - a prospective study of 12 cases. Am J Gastroenterol 1983, 78: 261-264.","journal-title":"Am J Gastroenterol"},{"issue":"443-445","key":"ref_4","first-page":"552","article-title":"Ketoconazole resistant Candida esophagitis in patients with acquired immunodeficiency syndrome","volume":"90","author":"Tavitian, A.; Raufman, J.P.; Rosenthal, L.E.; Weber, J.; Webber, C.A.; Dincsoy, H.P.","unstructured":"Tavitian, A., Raufman, J.P., Rosenthal, L.E., Weber, J., Webber, C.A. & Dincsoy, H.P. Ketoconazole resistant Candida esophagitis in patients with acquired immunodeficiency syndrome. Gastroenterology 1986, 90: 443-445. 552 A. GIL et al.","journal-title":"Gastroenterology"},{"issue":"7","key":"ref_5","first-page":"228","article-title":"Effect of food and gastric acidity on absorption of orally administered ketoconazole","volume":"1988","author":"Lelawongs, P.; Barone, J.A.; Izzi, J.L.","unstructured":"Lelawongs, P., Barone, J.A., Izzi, J.L. et al. Effect of food and gastric acidity on absorption of orally administered ketoconazole. Clin Pharm 1988, 7: 228-235.","journal-title":"Clin Pharm"},{"issue":"109","key":"ref_6","first-page":"471","article-title":"Gastropathy and ketoconazole malabsorption in the acquired immunodeficiency syndrome (AIDS)","volume":"1988","author":"Lake-Bakaar, G.; Tom, W.; Lake-Bakaar, D.","unstructured":"Lake-Bakaar, G., Tom, W., Lake-Bakaar, D. et al. Gastropathy and ketoconazole malabsorption in the acquired immunodeficiency syndrome (AIDS). 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Gastroenterology 1984, 86: 503-513.","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1056\/NEJM198412273112606","article-title":"Interaction of ketoconazole with rifampin and isoniazid","volume":"311","author":"Engelhard, D.; Stutman, H.R.; Marks, M.I.","year":"1984","unstructured":"Engelhard, D., Stutman, H.R. & Marks, M.I. Interaction of ketoconazole with rifampin and isoniazid. N Engi J Med 1984, 311: 1681-1683.","journal-title":"N Engi J Med"},{"issue":"7","key":"ref_10","first-page":"460","article-title":"Treatment of systemic fungal infections: recent progress and current problems","volume":"1988","author":"Walsh, T.J.; Pizzo, A.","unstructured":"Walsh, T.J. & Pizzo, A. Treatment of systemic fungal infections: recent progress and current problems. 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Fluconazole in the management of oropharyngeal candidiasis in a predominantly HIV antibody positive group ofpatients. JMed Vet Mycol 1988, 26: 67-71."},{"key":"ref_16","article-title":"Fluconazole: a new treatment for oropharyngeal candidiasis in AIDS and malignancy","volume-title":"Abst 949","author":"Farrow, P.R.; Brammer, K.W.; Feczko, J.M.","year":"1987","unstructured":"Farrow, P.R., Brammer, K.W. & Feczko, J.M. Fluconazole: a new treatment for oropharyngeal candidiasis in AIDS and malignancy. 27th ICAAC (Oct 4-7, New York) 1987; Abst 949.","edition":"27th ICAAC"},{"key":"ref_17","first-page":"15","article-title":"Centers for Disease Control: Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome","unstructured":"Centers for Disease Control: Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. 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Lancet 1984, i: 1253-1256.","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.314668","article-title":"Monoclonal antibodies defining distinctive human T cell surface antigens","volume":"206","author":"Kung, P.C.; Goldstein, G.; Reunherz, E.L.; Schlossman, S.F.","year":"1979","unstructured":"Kung, P.C., Goldstein, G., Reunherz, E.L. & Schlossman, S.F. Monoclonal antibodies defining distinctive human T cell surface antigens. Science 1979, 206: 347-349.","journal-title":"Science"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1128\/jcm.6.4.406-413.1977","article-title":"Automated microbiological detection identification system","volume":"6","author":"Aldridge, C.; Jones, P.W.; Gibson, S.F.","year":"1977","unstructured":"Aldridge, C., Jones, P.W., Gibson, S.F. et al. Automated microbiological detection identification system. J Clin Microbiol 1977, 6: 406-413.","journal-title":"J Clin Microbiol"},{"key":"ref_22","first-page":"19","article-title":"Fluconazole treatment of fungal infections in the immunocompromised host","volume":"6","author":"Meunier, F.","year":"1990","unstructured":"Meunier, F. Fluconazole treatment of fungal infections in the immunocompromised host. Semin Oncol 1990, 17 (Suppl 6): 19-23.","journal-title":"Semin Oncol"},{"key":"ref_23","first-page":"93","article-title":"Toxicology of fluconazole in experimental animals","volume-title":"Recent Trends in the Discovery, Development and Evaluation of Anti[ungal Agents","author":"Tachibana, M.; Noguchi, Y.; Monro, A.M.","year":"1987","unstructured":"Tachibana, M., Noguchi, Y. & Monro, A.M. Toxicology of fluconazole in experimental animals. In: Fromtling, R.A. (ed.) Recent Trends in the Discovery, Development and Evaluation of Anti[ungal Agents. JR Prous Science Pub SA, Barcelona, 1987, pp. 93-102."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/jac\/21.5.665","article-title":"A prospective study of the efficacy of fluconazole (UK-49858) against deep-seated fungal infections","volume":"21","author":"Van't Wout, J.W.; Mattie, H.; van Furth, R.","year":"1988","unstructured":"Van't Wout, J.W., Mattie, H. & van Furth, R. A prospective study of the efficacy of fluconazole (UK-49858) against deep-seated fungal infections. J Antimicrob Chemother 1988, 21: 665-672.","journal-title":"J Antimicrob Chemother"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.7326\/0003-4819-113-3-177","article-title":"Fluconazole, a new antifungal agent","volume":"113","author":"Galgiani, J.N.","year":"1990","unstructured":"Galgiani, J.N. Fluconazole, a new antifungal agent. 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J Infect Dis 1989, 159:. 806-807.","journal-title":"J Infect Dis"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/788\/548\/50075443\/postgradmedj-67-548.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/788\/548\/50075443\/postgradmedj-67-548.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T16:25:52Z","timestamp":1682612752000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/67\/788\/548\/7061710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6,1]]},"references-count":29,"journal-issue":{"issue":"788","published-online":{"date-parts":[[1991,6,1]]},"published-print":{"date-parts":[[1991,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.67.788.548","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1991,6]]},"published":{"date-parts":[[1991,6,1]]}}}