{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T01:41:03Z","timestamp":1698457263988},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"789","license":[{"start":{"date-parts":[[1991,7,1]],"date-time":"1991-07-01T00:00:00Z","timestamp":678326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,7,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Twenty-eight patients with atrial fibrillation of less than 1 month's duration were given a single intravenous bolus of flecainide (2 mg\/kg). Nineteen patients (68%) were successfully converted to sinus rhythm. Of the 19 patients with atrial fibrillation of less than 72 hours duration, 18 (95%) were successfully converted. Failure to cardiovert was associated with cardiomegaly on chest X-ray and larger left atrial diameter measured echocardiographically. Of the 9 patients who failed to convert, 2 had biochemical evidence of thyrotoxicosis and chronic obstructive pulmonary disease. Of the 19 patients successfully cardioverted, the atrial fibrillation complicated acute myocardial infarction in 3 cases and a pulmonary embolism in one. Six cases occurred post-operatively and in 3 out of 6 the patient was ventilated. No side effects were observed.<\/jats:p>\n               <jats:p>The use of intravenous flecainide should avoid the need for electrical DC conversion even in sick patients. Failure of conversion is associated with covert underlying predisposing factors and duration of atrial fibrillation of more than 72 hours.<\/jats:p>","DOI":"10.1136\/pgmj.67.789.659","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"659-662","source":"Crossref","is-referenced-by-count":9,"title":["Cardioversion of atrial fibrillation of recent onset with flecainide"],"prefix":"10.1093","volume":"67","author":[{"given":"B","family":"Carr","sequence":"first","affiliation":[{"name":"Department of Cardiology, Royal Hallamshire Hospital , Glossop Road, Sheffield S10 2JF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Hallamshire Hospital , Glossop Road, Sheffield S10 2JF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K S","family":"Channer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Hallamshire Hospital , Glossop Road, Sheffield S10 2JF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,7,1]]},"reference":[{"key":"ref_1","first-page":"1018","article-title":"Epidemiologic features of chronic atrial fibrillation","volume":"306","author":"Kannel, W.B.; Abbott, R.D.; Savage, D.D.; McNamara, P.M.","year":"1982","unstructured":"Kannel, W.B., Abbott, R.D., Savage, D.D. & McNamara, P.M. Epidemiologic features of chronic atrial fibrillation. The Framingham Study. N Engl J Med 1982, 306: 1018-1022.","journal-title":"The Framingham Study. N Engl J Med"},{"issue":"75","key":"ref_2","first-page":"1","article-title":"Atrial systole; its role in normal and diseased hearts","volume":"1988","author":"Channer, K.S.; Jones, J.V.","unstructured":"Channer, K.S. & Jones, J.V. Atrial systole; its role in normal and diseased hearts. Clin Sci 1988, 75: 1-4.","journal-title":"Clin Sci"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/01.STR.14.5.664","article-title":"Duration of atrial fibrillation and imminence of stroke","volume":"14","author":"Wolf, P.A.; Kanner, W.B.; McGee, D.L.; Meek, S.L.; Bharacha, N.E.; McNamara, P.M.","year":"1983","unstructured":"Wolf, P.A., Kanner, W.B., McGee, D.L., Meek, S.L., Bharacha, N.E. & McNamara, P.M. Duration of atrial fibrillation and imminence of stroke. The Framingham Study. Stroke 1983, 14: 664-667.","journal-title":"The Framingham Study. Stroke"},{"key":"ref_4","first-page":"233","article-title":"Clinical course of acute atrial fibrillation treated with rapid digitalisation","volume":"105","author":"Weiner, R.; Bassan, M.M.; Jarchovsky, J.; lusim, S.; Plavnick, L.","year":"1983","unstructured":"Weiner, R., Bassan, M.M., Jarchovsky, J., lusim, S. & Plavnick, L. Clinical course of acute atrial fibrillation treated with rapid digitalisation. Am Heart J 1983, 105: 233-237.","journal-title":"Am Heart J"},{"issue":"30","key":"ref_5","first-page":"653","article-title":"Cardiac output in auricular fibrillation with observations on the effects of conversion to sinus rhythm","volume":"1951","author":"Kory, R.C.; Meneely, G.R.","unstructured":"Kory, R.C. & Meneely, G.R. Cardiac output in auricular fibrillation with observations on the effects of conversion to sinus rhythm. J Clin Invest 1951, 30: 653.","journal-title":"J Clin Invest"},{"issue":"30","key":"ref_6","first-page":"647","article-title":"Cardiovascular adjustments in subjects with organic heart disease before and after conversion of atrial fibrillation to normal sinus rhythm","volume":"1951","author":"Hecht, H.H.; Osher, W.J.; Samuels, A.J.","unstructured":"Hecht, H.H., Osher, W.J. & Samuels, A.J. Cardiovascular adjustments in subjects with organic heart disease before and after conversion of atrial fibrillation to normal sinus rhythm. J Clin Invest 1951, 30: 647.","journal-title":"J Clin Invest"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0002-9149(89)90253-1","article-title":"Intravenous flecainide versus verapamil for acute conversion of paroxysmal atrial fibrillation or flutter to sinus rhythm","volume":"63","author":"Suttorp, M.J.; Kingma, J.H.; Lie-A-Huen, L.; Mast, E.G.","year":"1989","unstructured":"Suttorp, M.J., Kingma, J.H., Lie-A-Huen, L. & Mast, E.G Intravenous flecainide versus verapamil for acute conversion of paroxysmal atrial fibrillation or flutter to sinus rhythm. Am J Cardiol 1989, 63: 693-696.","journal-title":"Am J Cardiol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0002-9149(88)90503-6","article-title":"Restoration of sinus rhythm with flecainide in patients with atrial fibrillation","volume":"62","author":"Goy, J.J.; Kaufman, U.; Kappenberger, L.; Sigwart, U.","year":"1988","unstructured":"Goy, J.J., Kaufman, U., Kappenberger, L. & Sigwart, U. Restoration of sinus rhythm with flecainide in patients with atrial fibrillation. Am J Cardiol 1988; 62: 38D-40D.","journal-title":"Am J Cardiol"},{"issue":"59","key":"ref_9","first-page":"572","article-title":"Delayed improvement in exercise capacity after cardioversion of atrial fibrillation to sinus rhythm","volume":"1988","author":"Lipkin, D.P.; Frenneaux, M.; Stewart, R.; Joshi, J.; Lowe, T.; McKenna, W.J.","unstructured":"Lipkin, D.P., Frenneaux, M., Stewart, R., Joshi, J., Lowe, T. & McKenna, W.J. Delayed improvement in exercise capacity after cardioversion of atrial fibrillation to sinus rhythm. Br Heart J 1988, 59: 572-577.","journal-title":"Br Heart J"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1056\/NEJM198908103210629","article-title":"Preliminary report: effect of encainide and flecainide on mortality in a randomised trial of arrhythmia suppression after myocardial infarction","volume":"321","author":"investigators, C.A.S.T.","year":"1989","unstructured":"CAST investigators. Preliminary report: effect of encainide and flecainide on mortality in a randomised trial of arrhythmia suppression after myocardial infarction. N Engl J Med 1989, 321: 406-412.","journal-title":"N Engl J Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/789\/659\/50075403\/postgradmedj-67-659.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/789\/659\/50075403\/postgradmedj-67-659.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T16:37:19Z","timestamp":1682613439000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/67\/789\/659\/7061737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7,1]]},"references-count":10,"journal-issue":{"issue":"789","published-online":{"date-parts":[[1991,7,1]]},"published-print":{"date-parts":[[1991,7,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.67.789.659","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1991,7]]},"published":{"date-parts":[[1991,7,1]]}}}