{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:15:51Z","timestamp":1762017351413},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"789","license":[{"start":{"date-parts":[[1991,7,1]],"date-time":"1991-07-01T00:00:00Z","timestamp":678326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,7,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A case of histiocytosis X involving the thyroid and hypothalamus is reported. A 16 year old female presented with amenorrhoea and diabetes insipidus. She subsequently developed a painful goitre with biochemical hypothyroidism, and stridor. The stridor and goitre responded to cyclophosphamide. Previous publications on the use of cytotoxics in histiocytosis X involving the thyroid are reviewed. We describe for the first time both the ultrasound appearances of the thyroid in this condition and the use of serial volumetric measurements to monitor therapy.<\/jats:p>","DOI":"10.1136\/pgmj.67.789.680","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"680-682","source":"Crossref","is-referenced-by-count":20,"title":["Histiocytosis X involving the thyroid and hypothalamus"],"prefix":"10.1093","volume":"67","author":[{"given":"P","family":"Gaines","sequence":"first","affiliation":[{"name":"Department of Radiology, Prince of Wales Hospital , Shatin, New Territories, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C N","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Prince of Wales Hospital , Shatin, New Territories, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C S","family":"Cockram","sequence":"additional","affiliation":[{"name":"Department of Medicine, Prince of Wales Hospital , Shatin, New Territories, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1259\/0007-1285-60-714-525","article-title":"Changes in transplanted kidney volume measured by ultrasound","volume":"60","author":"Absy, M.; Metreweli, C.; Mathews, C.; Khader, A.A.","year":"1987","unstructured":"Absy, M., Metreweli, C., Mathews, C. & Khader, A.A. Changes in transplanted kidney volume measured by ultrasound. Br J Radiol 1987, 60: 525-529.","journal-title":"Br J Radiol"},{"issue":"14","key":"ref_2","first-page":"45","article-title":"Histiocytosis X: a review of the etiology, pathology, staging, and therapy","volume":"1986","author":"Grundy, R.; Ellis, R.","unstructured":"Grundy, R. & Ellis, R. Histiocytosis X: a review of the etiology, pathology, staging, and therapy. Med Pediatr Oncol 1986, 14: 45-50.","journal-title":"Med Pediatr Oncol"},{"key":"ref_3","article-title":"Clinical Pediatric Oncology","author":"Starling, K.A.","year":"1984","unstructured":"Starling, K.A. & Fernbach, D.S. Histiocytosis. In: Sutow, W. (ed.) Clinical Pediatric Oncology 3rd edition. C V Mosby Company, St Louis, 1984.","edition":"3"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/0002-9343(57)90115-8","article-title":"The course and prognosis of reticuloendotheliosis (eosinophilic granuloma, Schuller-Christian disease and Letterer-Siwe disease). A study of forty cases","volume":"22","author":"Avery, M.E.; McAfee, J.G.; Guild, H.G.","year":"1957","unstructured":"Avery, M.E., McAfee, J.G. & Guild, H.G. The course and prognosis of reticuloendotheliosis (eosinophilic granuloma, Schuller-Christian disease and Letterer-Siwe disease). A study of forty cases. Am J Med 1957, 22: 636-652.","journal-title":"Am J Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/000992287101000515","article-title":"Asymptomatic goitre as an expression ofa rare disease","volume":"10","author":"Whitaker, C.; Kenny, M.; Fetterman, G.H.","year":"1971","unstructured":"Whitaker, C., Kenny, M. & Fetterman, G.H. Asymptomatic goitre as an expression ofa rare disease. Clin Pediatr 1971, 10: 290-292.","journal-title":"Clin Pediatr"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.7326\/0003-4819-88-4-512","article-title":"Hypothalamic endocrinopathy in Hand-Schuller-Christian disease","volume":"88","author":"Rothman, J.G.; Snyder, P.J.; Utiger, R.D.","unstructured":"Rothman, J.G., Snyder, P.J. & Utiger, R.D. Hypothalamic endocrinopathy in Hand-Schuller-Christian disease. Ann Intern Med 88: 512-513.","journal-title":"Ann Intern Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1001\/archderm.1980.01640260094026","article-title":"Multifocal eosinophilic granuloma with skin ulceration. Histiocytosis X of the Hand-Schuller-Christian type","volume":"116","author":"Mahzoon, S.; Wood, M.G.","year":"1980","unstructured":"Mahzoon, S. & Wood, M.G. Multifocal eosinophilic granuloma with skin ulceration. Histiocytosis X of the Hand-Schuller-Christian type. Arch Dermatol 1980, 116: 218-220.","journal-title":"Arch Dermatol"},{"issue":"12","key":"ref_8","first-page":"1137","article-title":"Involvement of the thyroid gland in histiocytosis X","volume":"1981","author":"Teja, K.; Sabio, H.; Langdon, D.R.; Johanson, A.J.","unstructured":"Teja, K., Sabio, H., Langdon, D.R. & Johanson, A.J. Involvement of the thyroid gland in histiocytosis X. Hum Pathol 1981, 12: 1137-1139.","journal-title":"Hum Pathol"},{"key":"ref_9","first-page":"449","article-title":"Localisation thyroidienne d'une histiocytosis X","volume":"39","author":"Demeocq, F.; Boespflug, O.; Vanlieferinghen, P.","year":"1982","unstructured":"Demeocq, F., Boespflug, O., Vanlieferinghen, P. et al. Localisation thyroidienne d'une histiocytosis X. Arch Fr Pediatr 1982, 39: 449.","journal-title":"Arch Fr Pediatr"},{"issue":"15","key":"ref_10","first-page":"72","article-title":"Primary hypothyroidism and essential hypernatraemia in a patient with histiocytosis X","volume":"1985","author":"Ma, J.T.C.; Wang, C.; Ho, F.C.S.; Lam, K.S.L.; Yeung, R.T.T.","unstructured":"Ma, J.T.C., Wang, C., Ho, F.C.S., Lam, K.S.L. & Yeung, R.T.T. Primary hypothyroidism and essential hypernatraemia in a patient with histiocytosis X. Aust NZ J Med 1985, 15: 72-74.","journal-title":"Aust NZ J Med"},{"issue":"8","key":"ref_11","first-page":"257","article-title":"Involvement of the thyroid in histiocytosis X","volume":"1986","author":"Lahey, M.E.; Rallison, M.L.; Hilding, D.A.; Ater, J.","unstructured":"Lahey, M.E., Rallison, M.L., Hilding, D.A. & Ater, J. Involvement of the thyroid in histiocytosis X. Am J Pediatr Hematol Oncol 1986, 8: 257-259.","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0046-8177(88)80355-1","article-title":"Histiocytosis X of the thyroid masquerading as thyroid carcinoma","volume":"19","author":"Coode, P.E.; Shaikh, M.U.","year":"1988","unstructured":"Coode, P.E. & Shaikh, M.U. Histiocytosis X of the thyroid masquerading as thyroid carcinoma. Hum Pathol 1988, 19: 239-241.","journal-title":"Hum Pathol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0009-9260(05)80935-3","article-title":"Ultrasound appearances of De Quervain's thyroiditis","author":"Birchall, I.W.J.; Chow, C.C.; Metreweli, C.","year":"1990","unstructured":"Birchall, I.W.J., Chow, C.C. & Metreweli, C. Ultrasound appearances of De Quervain's thyroiditis. Clin Radiol 1990, 57-59.","journal-title":"Clin Radiol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0889-8588(18)30683-X","article-title":"Natural history of histiocytosis X","volume":"1","author":"Berry, D.H.; Becton, D.L.","year":"1987","unstructured":"Berry, D.H. & Becton, D.L. Natural history of histiocytosis X. 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