{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:05:42Z","timestamp":1759482342332},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"790","license":[{"start":{"date-parts":[[1991,8,1]],"date-time":"1991-08-01T00:00:00Z","timestamp":681004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 35 year old woman was admitted with acute radial artery occlusion necessitating two operations and thrombolytic therapy. Subsequently a diagnosis of primary hypothyroidism was made and she was commenced on thyroxine replacement therapy. Her condition, however, continued to deteriorate with the development of an Addisonian crisis heralded by, and complicated by, severe, life-threatening hypercalcaemia. This case highlights the importance of considering Addison's disease in any patient whose condition deteriorates after the introduction of thyroxine replacement, and illustrates the often forgotten association of hypercalcaemia and hypoadrenalism.<\/jats:p>","DOI":"10.1136\/pgmj.67.790.770","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"770-772","source":"Crossref","is-referenced-by-count":19,"title":["Life-threatening hypercalcaemia in association with Addisonian crisis"],"prefix":"10.1093","volume":"67","author":[{"given":"J","family":"Miell","sequence":"first","affiliation":[{"name":"Department of Medicine, King's College Hospital School of Medicine , Bessemer Road, London SE5 9PJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Wassif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"McGregor","sequence":"additional","affiliation":[{"name":"Department of Medicine, King's College Hospital School of Medicine , Bessemer Road, London SE5 9PJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, King's College Hospital School of Medicine , Bessemer Road, London SE5 9PJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Medicine, King's College Hospital School of Medicine , Bessemer Road, London SE5 9PJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,8,1]]},"reference":[{"issue":"76","key":"ref_1","first-page":"420","article-title":"Chemical changes in the blood in Addison's disease","volume":"1932","author":"Loeb, R.F.","unstructured":"Loeb, R.F. Chemical changes in the blood in Addison's disease. Science 1932, 76: 420-421.","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1365-2265.1981.tb00629.x","article-title":"Addison's disease presenting as hypercalcaemic crisis in a patient with idiopathic hypoparathyroidism","volume":"14","author":"Walker, D.A.; Davies, M.","year":"1981","unstructured":"Walker, D.A. & Davies, M. Addison's disease presenting as hypercalcaemic crisis in a patient with idiopathic hypoparathyroidism. Clin Endocrinol 1981, 14: 419-423.","journal-title":"Clin Endocrinol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1210\/jcem-42-5-953","article-title":"Cortisol-dihydrotachysterol antagonism in a patient with hypoparathyroidism and adrenal insufficiency: apparent inhibition ofbone resorption","volume":"42","author":"Farrell, P.M.; Rikkers, H.; Moel, D.","year":"1976","unstructured":"Farrell, P.M., Rikkers, H. & Moel, D. Cortisol-dihydrotachysterol antagonism in a patient with hypoparathyroidism and adrenal insufficiency: apparent inhibition ofbone resorption. J Clin Endocrinol Metab 1976, 42: 953-957.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_4","first-page":"145","article-title":"Hypercalcaemic crisis as a presentation of Addison's disease","volume":"i:","author":"Downie, W.W.; Gunn, A.; Paterson, G.R.; Howie, G.F.A.","year":"1977","unstructured":"Downie, W.W., Gunn, A., Paterson, G.R. & Howie, G.F.A. Hypercalcaemic crisis as a presentation of Addison's disease. Br Med J 1977, i: 145-146.","journal-title":"Br Med J"},{"issue":"42","key":"ref_5","first-page":"456","article-title":"The hypercalcaemia of adrenal insufficiency","volume":"1963","author":"Walser, M.; Robinson, B.H.B.; Ducket, J.W.","unstructured":"Walser, M., Robinson, B.H.B. & Ducket, J.W. The hypercalcaemia of adrenal insufficiency. J Clin Invest 1963, 42: 456-465.","journal-title":"J Clin Invest"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0954-6820.1947.tb06583.x","article-title":"A study of the metabolism in Addison's disease II. On the metabolism of lipids, nitrogen and minerals, and on the vitamin C household","volume":"128","author":"Helve, 0","year":"1947","unstructured":"Helve, 0. A study of the metabolism in Addison's disease II. On the metabolism of lipids, nitrogen and minerals, and on the vitamin C household. Acta Med Scand 1947, 128: 1-7.","journal-title":"Acta Med Scand"},{"issue":"156","key":"ref_7","first-page":"455","article-title":"Hypercalcaemia in adrenal insufficiency","volume":"1957","author":"Leeksma, C.H.W.; De Graeff, J.; De Cock, J.","unstructured":"Leeksma, C.H.W., De Graeff, J. & De Cock, J. Hypercalcaemia in adrenal insufficiency. Acta Med Scand 1957, 156: 455-462.","journal-title":"Acta Med Scand"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.0954-6820.1967.tb07987.x","article-title":"Hypercalcaemia in Addison's disease","volume":"181","author":"Pederson, K.O.","year":"1967","unstructured":"Pederson, K.O. Hypercalcaemia in Addison's disease. Acta Med Scand 1967, 181: 691-694.","journal-title":"Acta Med Scand"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.0954-6820.1973.tb10558.x","article-title":"Hypercalcaemia in adrenocortical insufficiency","volume":"193","author":"J0rgensen, H.","year":"1973","unstructured":"J0rgensen, H. Hypercalcaemia in adrenocortical insufficiency. Acta Med Scand 1973, 193: 175-179.","journal-title":"Acta Med Scand"},{"issue":"217","key":"ref_10","first-page":"1277","article-title":"Normocalcaemia in relation to cortisone secretion","volume":"1968","author":"Jowsey, J.; Simons, G.","unstructured":"Jowsey, J. & Simons, G. Normocalcaemia in relation to cortisone secretion. Nature 1968, 217: 1277-1278.","journal-title":"Nature"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/790\/770\/50075550\/postgradmedj-67-770.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/790\/770\/50075550\/postgradmedj-67-770.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T16:38:16Z","timestamp":1682613496000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/67\/790\/770\/7061810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8,1]]},"references-count":10,"journal-issue":{"issue":"790","published-online":{"date-parts":[[1991,8,1]]},"published-print":{"date-parts":[[1991,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.67.790.770","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1991,8]]},"published":{"date-parts":[[1991,8,1]]}}}