{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T06:10:14Z","timestamp":1682662214657},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"791","license":[{"start":{"date-parts":[[1991,9,1]],"date-time":"1991-09-01T00:00:00Z","timestamp":683683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Previous epidemiological studies have described the secular trends in peptic ulcer mortality in England and Wales as being characteristic of a cohort phenomenon. The most recent data on ulcer mortality, however, show increasing mortality rates from duodenal ulcer in women over 65 and from gastric ulcer in women over 75 years. While the rise in mortality rates in the oldest age groups is partly explained by their greater life expectancy, the increase in mortality from duodenal ulcer in older women shows evidence of an environmental (period) effect being superimposed on female cohorts born between 1895 and 1925. This effect could partly be due to the increasing consumption of non-steroidal anti-inflammatory drugs which coincides with the rise in mortality rates.<\/jats:p>","DOI":"10.1136\/pgmj.67.791.825","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"825-828","source":"Crossref","is-referenced-by-count":6,"title":["Changes in birth \u2013 cohort pattern of peptic ulcer mortality in England and Wales"],"prefix":"10.1093","volume":"67","author":[{"given":"B D","family":"Katschinski","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, University Hospital Essen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R F","family":"Logan","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Epidemiology, University Hospital , Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0021-9681(82)90027-3","article-title":"Period effects, generation effects and age effects in peptic ulcer mortality","volume":"35","author":"Susser, M.","year":"1982","unstructured":"Susser, M. Period effects, generation effects and age effects in peptic ulcer mortality. J Chron Dis 1982, 35: 29-40.","journal-title":"J Chron Dis"},{"key":"ref_2","first-page":"115","article-title":"Civilisation and peptic ulcer","volume":"i:","author":"Susser, M.","unstructured":"Susser, M. Civilisation and peptic ulcer. Lancet 1962, i: 115-119.","journal-title":"Lancet 1962"},{"key":"ref_3","first-page":"489","article-title":"Rising frequency of ulcer perforation in elderly people in the United Kingdom","volume":"1","author":"Walt, R.; Katschinski, B.; Logan, R.","year":"1986","unstructured":"Walt, R., Katschinski, B., Logan, R. et al. Rising frequency of ulcer perforation in elderly people in the United Kingdom. Lancet 1986, 1: 489-492.","journal-title":"Lancet"},{"key":"ref_4","article-title":"General Household Survey 1982; 12 Chapter 9","volume-title":"HM Stationery Office,","year":"1983","unstructured":"General Household Survey 1982; 12 Chapter 9. HM Stationery Office, London, 1983."},{"issue":"1","key":"ref_5","first-page":"1302","article-title":"20 years of hospital admission for peptic ulcer in England and Wales","volume":"1981","author":"Coggon, D.; Lambert, P.; Langman, M.J.S.","unstructured":"Coggon, D., Lambert, P. & Langman, M.J.S. 20 years of hospital admission for peptic ulcer in England and Wales. Lancet 1981, 1: 1302-1304.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1136\/gut.27.11.1369","article-title":"Smoking and mortality from peptic ulcer in the United Kingdom","volume":"27","author":"Sonnenberg, A.","year":"1986","unstructured":"Sonnenberg, A. Smoking and mortality from peptic ulcer in the United Kingdom. Gut 1986, 27: 1369-1372.","journal-title":"Gut"},{"issue":"26","key":"ref_7","first-page":"789","article-title":"Environmental factors in aetiology of chronic gastric ulcer: a case control study of exposure variables before the first symptoms","volume":"1985","author":"McIntosh, J.; Byth, K.; Piper, D.","unstructured":"McIntosh, J., Byth, K. & Piper, D. Environmental factors in aetiology of chronic gastric ulcer: a case control study of exposure variables before the first symptoms. Gut 1985, 26: 789-798.","journal-title":"Gut"},{"issue":"27","key":"ref_8","first-page":"929","article-title":"Peptic ulcer and non-steroidal anti-inflammatory agents","volume":"1986","author":"Duggan, J.M.; Dobson, A.J.; Johnson, H.","unstructured":"Duggan, J.M., Dobson, A.J., Johnson, H. et al. Peptic ulcer and non-steroidal anti-inflammatory agents. 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Arch Intern Med 1987, 147: 85-88.","journal-title":"Arch Intern Med"},{"key":"ref_11","first-page":"380","article-title":"Non-steroidal anti-inflammatory drugs and hospital admission for perforated peptic ulcer","volume":"ii:","author":"Jick, S.S.; Perera, D.R.; Walker, A.M.","year":"1987","unstructured":"Jick, S.S., Perera, D.R., Walker, A.M. et al. Non-steroidal anti-inflammatory drugs and hospital admission for perforated peptic ulcer. Lancet 1987, ii: 380-382.","journal-title":"Lancet"},{"issue":"109","key":"ref_12","first-page":"359","article-title":"Non-steroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons","volume":"1988","author":"Griffin, M.R.; Ray, W.A.; Schaffner, W.","unstructured":"Griffin, M.R., Ray, W.A. & Schaffner, W. Non-steroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons. 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Ned Tijdschr Geneeskd 1984, 128: 484-491.","journal-title":"Ned Tijdschr Geneeskd"},{"key":"ref_15","first-page":"309","article-title":"Cohort analysis of peptic ulcer mortality in Europe","volume":"88","author":"Sonnenberg, A.; Muller, H.; Pace, F.","year":"1984","unstructured":"Sonnenberg, A., Muller, H. & Pace, F. Cohort analysis of peptic ulcer mortality in Europe. J Chron Dis 1984, 88: 309-317.","journal-title":"J Chron Dis"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"700","DOI":"10.2105\/AJPH.76.6.700","article-title":"Sex and smoking differences in duodenal ulcer mortality","volume":"76","author":"Kurata, J.H.; Elashoff, J.D.; Nogawa, A.N.","year":"1986","unstructured":"Kurata, J.H., Elashoff, J.D., Nogawa, A.N. et al. Sex and smoking differences in duodenal ulcer mortality. 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