{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:23:41Z","timestamp":1760189021220},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"793","license":[{"start":{"date-parts":[[1991,11,1]],"date-time":"1991-11-01T00:00:00Z","timestamp":688953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Although there is good evidence that d-penicillamine can induce polymyositis, the exact pathogenic mechanism remains unclear. We report two patients with psoriatic arthritis and primary biliary cirrhosis respectively, who developed polymyositis while receiving d-penicillamine treatment for their primary diseases. Whether d-penicillamine treatment was the sole cause of polymyositis or acted as a trigger for the development of a secondary autoimmune disease is discussed.<\/jats:p>","DOI":"10.1136\/pgmj.67.793.1018","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"1018-1020","source":"Crossref","is-referenced-by-count":8,"title":["Polymyositis complicating <scp>d<\/scp>-penicillamine treatment"],"prefix":"10.1093","volume":"67","author":[{"given":"A O","family":"Aydintug","sequence":"first","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Cervera","sequence":"additional","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"D'Cruz","sequence":"additional","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Asherson","sequence":"additional","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Khamashta","sequence":"additional","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G R","family":"Hughes","sequence":"additional","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1001\/archneur.1972.00490170088013","article-title":"Polymyositis and penicillamine","volume":"27","author":"Schraeder, P.L.; Peters, H.A.; Dahl, D.S.","year":"1972","unstructured":"Schraeder, P.L., Peters, H.A. & Dahl, D.S. Polymyositis and penicillamine. Arch Neurol 1972, 27: 456-457.","journal-title":"Arch Neurol"},{"issue":"74","key":"ref_2","first-page":"1286","article-title":"Penicillamine-induced polymyositis in a patient with rheumatoid arthritis","volume":"1981","author":"Fischer, R.G.; Pernebaker, J.B.","unstructured":"Fischer, R.G. & Pernebaker, J.B. Penicillamine-induced polymyositis in a patient with rheumatoid arthritis. South Med J 1981, 74: 1286.","journal-title":"South Med J"},{"key":"ref_3","first-page":"56","volume":"8","author":"Dawkins, R.L.; Zilko, P.J.; Carrano, J.; Garlepp, M.J.; McDonald, B.L.","year":"1981","unstructured":"Dawkins, R.L., Zilko, P.J., Carrano, J., Garlepp, M.J. & McDonald, B.L. Immunobiology of D-penicillamine. J Rheumatol 1981, 8 (Suppl): 56-61.","journal-title":"Immunobiology of D-penicillamine. J Rheumatol"},{"issue":"29","key":"ref_4","first-page":"560","article-title":"D-penicillamine induced polymyositis in patients with rheumatoid arthritis","volume":"1986","author":"Takahashi, K.; Ogita, T.; Okudaira, H.; Yoshinoya, S.; Yoshizawa, H.; Miyomoto, T.","unstructured":"Takahashi, K., Ogita, T., Okudaira, H., Yoshinoya, S., Yoshizawa, H. & Miyomoto, T. D-penicillamine induced polymyositis in patients with rheumatoid arthritis. Arthritis Rheum 1986, 29: 560-564.","journal-title":"Arthritis Rheum"},{"key":"ref_5","first-page":"995","article-title":"Penicillamine induced polymyositis and dermatomyositis","volume":"14","author":"Carroll, G.J.; Will, R.K.; Peter, J.B.; Garlepp, M.J.; Dawkins, R.L.","year":"1987","unstructured":"Carroll, G.J., Will, R.K., Peter, J.B., Garlepp, M.J. & Dawkins, R.L. Penicillamine induced polymyositis and dermatomyositis. J Rheumatol 1987, 14: 995-1001.","journal-title":"J Rheumatol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJM197502202920807","article-title":"Polymyositis and dermatomyositis","volume":"292","author":"Bohan, A.; Peter, J.B.","year":"1975","unstructured":"Bohan, A. & Peter, J.B. Polymyositis and dermatomyositis. N Engi J Med 1975, 292: 403-407.","journal-title":"N Engi J Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3109\/03009747809098847","article-title":"Penicillamine-induced polymyositis-dermatomyositis","volume":"7","author":"Petersen, J.; Halberg, P.; Hojgaard, K.; Lyon, B.B.; Ullman, S.","year":"1978","unstructured":"Petersen, J., Halberg, P., Hojgaard, K., Lyon, B.B. & Ullman, S. Penicillamine-induced polymyositis-dermatomyositis. Scand J Rhewnatol 1978, 7: 113-117.","journal-title":"Scand J Rhewnatol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"615","DOI":"10.7326\/0003-4819-85-5-615","article-title":"D-Penicillamine-induced polymyositis in rheumatoid arthritis","volume":"85","author":"Cucher, B.G.; Goldman, A.L.","year":"1976","unstructured":"Cucher, B.G. & Goldman, A.L. D-Penicillamine-induced polymyositis in rheumatoid arthritis. Ann Intern Med 1976, 85: 615-616.","journal-title":"Ann Intern Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.7326\/0003-4819-98-3-327","article-title":"Fatal polytnyositis in o-penicillamine-treated rheumatoid arthritis","volume":"98","author":"Doyle, D.R.; McCurley, L.; Sergent, J.S.","year":"1983","unstructured":"Doyle, D.R., McCurley, L. & Sergent, J.S. Fatal polytnyositis in o-penicillamine-treated rheumatoid arthritis. Ann Intern Med 1983, 98: 327-330.","journal-title":"Ann Intern Med"},{"key":"ref_10","first-page":"362","article-title":"Autoantibodies induced by D-penicillamine. In: Immunogenetics in Rheumatology. Exerpta Medica","author":"Carrano, J.A.; Zilko, P.; J.; Dawkins, R.L.","year":"1982","unstructured":"Carrano, J.A., Zilko, P,J. & Dawkins, R.L. Autoantibodies induced by D-penicillamine. In: Immunogenetics in Rheumatology. Exerpta Medica, Amsterdam, 1982, pp. 362-367."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/ard.36.1.94","article-title":"Dermatomyositis complicating penicillamine treatment","volume":"36","author":"Fernandes, L.; Swinson, D.R.; Hamilton, E.B.D.","year":"1977","unstructured":"Fernandes, L., Swinson, D.R. & Hamilton, E.B.D. Dermatomyositis complicating penicillamine treatment. Ann Rheum Dis 1977, 36: 94-95.","journal-title":"Ann Rheum Dis"},{"key":"ref_12","article-title":"Lupuslike syndrome induced by D-penicillamine in Wilson's disease","volume":"292","author":"Harpey, J.P.; Caille, B.; Moulias, R.; Gaust, J.M.","year":"1971","unstructured":"Harpey, J.P., Caille, B., Moulias, R. & Gaust, J.M. Lupuslike syndrome induced by D-penicillamine in Wilson's disease. Lancet 1971, i: 292.","journal-title":"Lancet"},{"key":"ref_13","first-page":"71","article-title":"Lupus induit par la D-penicillamine au cours du traitment de la polyarthrite rhumatoide. Deux observations et etude immunologique systematique au cours du traitment","volume":"125","author":"Crouzet, J.; Camus, J.P.; Leca, A.P.","year":"1974","unstructured":"Crouzet, J., Camus, J.P., Leca, A.P. et al. Lupus induit par la D-penicillamine au cours du traitment de la polyarthrite rhumatoide. Deux observations et etude immunologique systematique au cours du traitment. Ann Med Interne (Paris) 1974, 125: 71-79.","journal-title":"Ann Med Interne (Paris)"},{"key":"ref_14","first-page":"497","article-title":"Syndrome de GourgeretSjogren induit par la D-penicillamine. A propos d'un cas","volume":"44","author":"May, V.; Aristoff, H.; Lecog, G.","year":"1977","unstructured":"May, V., Aristoff, H. & Lecog, G. Syndrome de GourgeretSjogren induit par la D-penicillamine. A propos d'un cas. Rev Rhum Mal Osteoartic 1977, 44: 497-501.","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"673","DOI":"10.7326\/0003-4819-82-5-673","article-title":"D-penicillamineinduced Goodpasture's syndrome in Wilson's disease","volume":"82","author":"Sternlieb, I.; Bennett, B.; Scheinberg, I.H.","year":"1975","unstructured":"Sternlieb, I., Bennett, B. & Scheinberg, I.H. D-penicillamineinduced Goodpasture's syndrome in Wilson's disease. Ann Intern Med 1975, 82: 673-676.","journal-title":"Ann Intern Med"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1136\/bmj.1.5958.600","article-title":"Myasthenia gravis associated with penicillamine treatment for rheumatoid arthritis","volume":"1","author":"Bucknall, R.C.; Dixon, A.St J.; Glieb, E.N.","year":"1975","unstructured":"Bucknall, R.C., Dixon, A.St.J. & Glieb, E.N. Myasthenia gravis associated with penicillamine treatment for rheumatoid arthritis. Br Med J 1975, 1: 600-602.","journal-title":"Br Med J"},{"key":"ref_17","first-page":"2","article-title":"Pemphigus foliaceus induced by penicillamine","volume":"1976","author":"Marsden, R.A.; Ryan, T.J.; Vangehan, R.I.; Walshe, M.","unstructured":"Marsden, R.A., Ryan, T.J., Vangehan, R.I., Walshe, M. et al. Pemphigus foliaceus induced by penicillamine. 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Autoimmune side effects during treatment of rheumatoid arthritis with D-pencillamine: a clinical study. In: Maini, R.N., Berry, H. (eds) Modulation of Autoimmunity and Disease-The Penicillamine Experience. 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