{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:04:33Z","timestamp":1776449073647,"version":"3.51.2"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"794","license":[{"start":{"date-parts":[[1991,12,1]],"date-time":"1991-12-01T00:00:00Z","timestamp":691545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Thirty-nine elderly patients, mean age 77 years (range 65 to 96), with ejection systolic murmurs were studied to evaluate the functional significance of these murmurs. Subjects were evaluated clinically, by 2-D echocardiography, and by a full Doppler echocardiography study. Good quality Doppler signals were obtained in 35 subjects. Mitral regurgitation was found to be the only significant valvular lesion in 6 patients (17%). Doppler gradients in systole across the aortic valve were less than 30 mmHg in 28 subjects (80%) and were considered not significant. Gradients of greater than 30 mmHg representing significant aortic stenosis were found in 7 subjects (20%). The clinical sensitivity in detecting significant aortic stenosis was 44% and specificity was 81%. Doppler evidence of significant aortic stenosis was found in a substantial proportion of these elderly subjects. Neither clinical assessment nor 2-D echocardiography can be relied on to exclude this condition.<\/jats:p>","DOI":"10.1136\/pgmj.67.794.1059","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"1059-1061","source":"Crossref","is-referenced-by-count":11,"title":["Doppler echocardiography in elderly patients with ejection systolic murmurs"],"prefix":"10.1093","volume":"67","author":[{"given":"G M","family":"McKillop","sequence":"first","affiliation":[{"name":"Department of Medicine, Victoria Infirmary , Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Stewart","sequence":"additional","affiliation":[{"name":"Victoria Geriatric Unit , Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M A","family":"Burns","sequence":"additional","affiliation":[{"name":"Victoria Geriatric Unit , Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Ballantyne","sequence":"additional","affiliation":[{"name":"Department of Medicine, Victoria Infirmary , Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,12,1]]},"reference":[{"issue":"20","key":"ref_1","first-page":"370","article-title":"The aortic systolic murmur developing with increasing age","volume":"1958","author":"Bruns, D.L.; Van der Hauwert, L.G.","unstructured":"Bruns, D.L. & Van der Hauwert, L.G. The aortic systolic murmur developing with increasing age. Br Heart J 1958, 20: 370-378.","journal-title":"Br Heart J"},{"issue":"11","key":"ref_2","first-page":"763","article-title":"Heart sounds in the aged","volume":"1963","author":"Bethel, C.S.; Crow, E.W.","unstructured":"Bethel, C.S. & Crow, E.W. Heart sounds in the aged. Am J Cardiol 1963, 11: 763-767.","journal-title":"Am J Cardiol"},{"issue":"75","key":"ref_3","first-page":"752","article-title":"A point score system for the ECG diagnosis of left ventricular hypertrophy","volume":"1968","author":"Rhomilt, D.W.; Estes, D.H.","unstructured":"Rhomilt, D.W. & Estes, D.H. A point score system for the ECG diagnosis of left ventricular hypertrophy. Am Heart J 1968, 75: 752-758.","journal-title":"Am Heart J"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/0002-9149(86)90851-9","article-title":"Comparison of Doppler derived pressure gradient to that derived at cardiac catheterisation in adults with aortic valve stenosis: implications for management","volume":"57","author":"Yeager, M.; Yock, P.G.; Popp, R.L.","year":"1986","unstructured":"Yeager, M., Yock, P.G. & Popp, R.L. Comparison of Doppler derived pressure gradient to that derived at cardiac catheterisation in adults with aortic valve stenosis: implications for management. Am J Cardiol 1986, 57: 644-648.","journal-title":"Am J Cardiol"},{"issue":"255","key":"ref_5","first-page":"3145","article-title":"Value and limitations of continuous wave Doppler echocardiography in estimating severity of valvular stenosis","volume":"1986","author":"Smith, M.D.; Kwan, O.L.; Demaria, A.N.","unstructured":"Smith, M.D., Kwan, O.L. & Demaria, A.N. Value and limitations of continuous wave Doppler echocardiography in estimating severity of valvular stenosis. JAMA 1986, 255: 3145-3151.","journal-title":"JAMA"},{"issue":"59","key":"ref_6","first-page":"551","article-title":"Limitations in assessing the severity of aortic stenosis by Doppler gradients","volume":"1988","author":"Danielsen, R.; Nordrehaug, J.E.; Stangeland, L.; Vik-Mo, H.","unstructured":"Danielsen, R., Nordrehaug, J.E., Stangeland, L. & Vik-Mo, H. Limitations in assessing the severity of aortic stenosis by Doppler gradients. Br Heart J 1988, 59: 551-555.","journal-title":"Br Heart J"},{"issue":"78","key":"ref_7","first-page":"267","article-title":"Clinical evaluation versus Doppler echocardiography in the quantitative assessment of valvular heart disease","volume":"1988","author":"Jaffe, W.D.; Roche, J.H.D.; Coverdale, H.A.; McAllister, H.F.; Ormiston, J.A.; Greene, E.R.","unstructured":"Jaffe, W.D., Roche, J.H.D., Coverdale, H.A., McAllister, H.F., Ormiston, J.A. & Greene, E.R. Clinical evaluation versus Doppler echocardiography in the quantitative assessment of valvular heart disease. Circulation 1988, 78: 267-275.","journal-title":"Circulation"},{"key":"ref_8","first-page":"43","article-title":"Aortic valve disease","volume-title":"Cardiac Doppler Ultrasound: A Clinical Perspective","author":"Hagler, D.","year":"1988","unstructured":"Hagler, D. Aortic valve disease. In: Houston, A.B. & Simpson, I.A. (eds).Cardiac Doppler Ultrasound: A Clinical Perspective. Wright, London, 1988, pp. 43-48."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/794\/1059\/49386811\/postgradmedj-67-1059.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/67\/794\/1059\/49386811\/postgradmedj-67-1059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T18:08:02Z","timestamp":1681754882000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/67\/794\/1059\/7061846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12,1]]},"references-count":8,"journal-issue":{"issue":"794","published-online":{"date-parts":[[1991,12,1]]},"published-print":{"date-parts":[[1991,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.67.794.1059","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1991,12]]},"published":{"date-parts":[[1991,12,1]]}}}