{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:06:50Z","timestamp":1760249210595},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"795","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Noonan's syndrome involves the association of multiple congenital abnormalities including neck webbing, pectus excavatum, facial anomalies with a variety of cardiac defects. In this paper the association of Noonan's syndrome with a large cerebral arteriovenous malformation is reported. Congenital cerebrovascular abnormalities are not a recognized feature of the syndrome. The paper also reviews previous reports of neurological associations with Noonan's syndrome, the commonest being mild intellectual impairment and ptosis.<\/jats:p>","DOI":"10.1136\/pgmj.68.795.37","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"37-40","source":"Crossref","is-referenced-by-count":30,"title":["Cerebral arteriovenous malformation in Noonan's syndrome"],"prefix":"10.1093","volume":"68","author":[{"given":"F","family":"Schon","sequence":"first","affiliation":[{"name":"Department of Neurology, Atkinson Morley's Hospital , Copse Hill, London, SW20 0NE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Bowler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Atkinson Morley's Hospital , Copse Hill, London, SW20 0NE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Baraitser","sequence":"additional","affiliation":[{"name":"Institute of Neurology, National Hospitalfor Nervous Diseases , Queen Square, London, WCIN 3BG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,1,1]]},"reference":[{"key":"ref_1","first-page":"468","article-title":"Associated noncardiac malformations in children with congenital heart disease","volume":"63","author":"Noonan, J.A.; Ehmke, D.A.","year":"1983","unstructured":"Noonan, J.A. & Ehmke, D.A. Associated noncardiac malformations in children with congenital heart disease. J Pediat 1983, 63: 468-470.","journal-title":"J Pediat"},{"issue":"116","key":"ref_2","first-page":"373","article-title":"Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease","volume":"1968","author":"Noonan, J.A.","unstructured":"Noonan, J.A. Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease. Am J Dis Child 1968, 116: 373-380.","journal-title":"Am J Dis Child"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/jmg.24.1.9","article-title":"Noonan syndrome","volume":"24","author":"Allanson, J.E.","year":"1987","unstructured":"Allanson, J.E. Noonan syndrome. J Med Genet 1987, 24: 9-13.","journal-title":"J Med Genet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1378\/chest.71.5.677","article-title":"Cardiovascular anomalies in Noonan's syndrome","volume":"71","author":"Pearl, W.","year":"1977","unstructured":"Pearl, W. Cardiovascular anomalies in Noonan's syndrome. Chest 1977, 71: 677-697.","journal-title":"Chest"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF02082326","article-title":"Unusual combination of congenital heart lesions in a child with Noonan's syndrome","volume":"3","author":"Lam, J.; Corno, A.; Oorthuys, H.W.E.; Marcellettic, E.","year":"1982","unstructured":"Lam, J., Corno, A., Oorthuys, H.W.E. & Marcellettic, E. Unusual combination of congenital heart lesions in a child with Noonan's syndrome. Ped Cardiol 1982, 3: 23-26.","journal-title":"Ped Cardiol"},{"issue":"71","key":"ref_6","first-page":"140","article-title":"Intracranial aneurysm in association with Noonan's syndrome","volume":"1984","author":"McAnena, O.; Buckley, T.F.; Padilla, J.R.","unstructured":"McAnena, O., Buckley, T. F. & Padilla, J.R. Intracranial aneurysm in association with Noonan's syndrome. Irish Med J 1984, 71: 140-141.","journal-title":"Irish Med J"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1001\/archpedi.1979.02130080086018","article-title":"Noonan's syndrome: IQ and specific disabilities","volume":"133","author":"Money, J.; Kalns, M.E.","year":"1979","unstructured":"Money, J. & Kalns, M.E. Noonan's syndrome: IQ and specific disabilities. Am J Dis Child 1979, 133: 846-850.","journal-title":"Am J Dis Child"},{"key":"ref_8","first-page":"48","article-title":"Ullrich-Noonan syndrome (Turner phenotype)","volume":"127","author":"Nora, J.J.; Nora, A.H.; Sinha, A.K.; Spangler, R.D.; Lubs, H.A.","year":"1974","unstructured":"Nora, J.J., Nora, A.H., Sinha, A.K., Spangler, R.D. & Lubs, H.A. Ullrich-Noonan syndrome (Turner phenotype). Am J Dis Child 1974, 127: 48-55.","journal-title":"Am J Dis Child"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/0002-9394(72)90466-7","article-title":"Noonan's syndrome associated with ocular abnormalities","volume":"73","author":"Schwartz, D.E.","year":"1970","unstructured":"Schwartz, D.E. Noonan's syndrome associated with ocular abnormalities. Am J Ophthalmol 1970, 73: 955.","journal-title":"Am J Ophthalmol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0022-3476(75)80974-7","article-title":"An evaluation of the possible association of malignant hyperthermia with Noonan's syndrome using serum creatinine phosphokinase levels","volume":"96","author":"Hunter, A.; Pinsky, L.","year":"1975","unstructured":"Hunter, A. & Pinsky, L. An evaluation of the possible association of malignant hyperthermia with Noonan's syndrome using serum creatinine phosphokinase levels. J Pediat 1975, 96: 412-415.","journal-title":"J Pediat"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1136\/jnnp.45.8.753","article-title":"Chiari (type 1) malformation and syringomyelia in a patient with Noonan's syndrome","volume":"45","author":"Ball, M.J.; Peiris, A.","year":"1982","unstructured":"Ball, M.J. & Peiris, A. Chiari (type 1) malformation and syringomyelia in a patient with Noonan's syndrome. J Neurol Neurosurg Psychiat 1982, 45: 753-754.","journal-title":"J Neurol Neurosurg Psychiat"},{"key":"ref_12","first-page":"101","article-title":"Noonan's syndrome with syringomyelia","volume":"40","author":"Kobayashil, I.; Aikawa, T.; Titakemiya, T.; Maruyama, S.; Takaho, K.","year":"1986","unstructured":"Kobayashil, I., Aikawa, T., Titakemiya, T., Maruyama, S. & Takaho, K. Noonan's syndrome with syringomyelia. Jap J Psych Neurol 1986, 40: 101-104.","journal-title":"Jap J Psych Neurol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/ajmg.1320260331","article-title":"Evidence that the neurofibromatosis-Noonan syndrome is a variant of Von Recklinghausen neurofibromatosis","volume":"26","author":"Meineoke, P.","year":"1987","unstructured":"Meineoke, P. Evidence that the neurofibromatosis-Noonan syndrome is a variant of Von Recklinghausen neurofibromatosis. Am J Med Genet 1987, 26: 741-745.","journal-title":"Am J Med Genet"},{"issue":"21","key":"ref_14","first-page":"457","article-title":"Noonan phenotype associated with neurofibromatosis","volume":"1985","author":"Allanson, J.E.; Hall, J.G.; Van Allen, M.I.","unstructured":"Allanson, J.E., Hall, J.G. & Van Allen, M.I. Noonan phenotype associated with neurofibromatosis. Am J Med Genet 1985, 21: 457-462.","journal-title":"Am J Med Genet"},{"key":"ref_15","first-page":"577","article-title":"Zerebrale anomalien bei Noonan syndrome","volume":"192","author":"Gorke, W.","year":"1980","unstructured":"Gorke, W. Zerebrale anomalien bei Noonan syndrome. Clinik Pediatr 1980, 192: 577-581.","journal-title":"Clinik Pediatr"},{"issue":"33","key":"ref_16","first-page":"177","article-title":"Noonan syndrome","volume":"1985","author":"Unnithan, R.R.; Bahnleyant, C.G.; Matnewroy, V.C.","unstructured":"Unnithan, R.R., Bahnleyant, C.G. & Matnewroy, V.C. Noonan syndrome. Assoc Physic India 1985, 33: 177-179.","journal-title":"Assoc Physic India"},{"issue":"116","key":"ref_17","first-page":"359","article-title":"Noonan's syndrome. A case with elevated serum alkaline phosphatase levels and malignant schwannoma of the left forearm","volume":"1968","author":"Kaplan, M.S.; Optiz, J.M.; Gosset, F.R.","unstructured":"Kaplan, M.S., Optiz, J.M. & Gosset, F.R. Noonan's syndrome. A case with elevated serum alkaline phosphatase levels and malignant schwannoma of the left forearm. Am J Dis Child 1968, 116: 359-366.","journal-title":"Am J Dis Child"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/ajmg.1320250303","article-title":"New multiple congenital anomalies\/mental retardation syndrome with cardio-facio-cutaneous involvement-The CFC syndrome","volume":"25","author":"Reynolds, J.F.; Neri, G.; Jermann, J.P.","year":"1986","unstructured":"Reynolds, J.F., Neri, G., Jermann, J.P. et al. New multiple congenital anomalies\/mental retardation syndrome with cardio-facio-cutaneous involvement-The CFC syndrome. Am J Med Genet 1986, 25: 413-427.","journal-title":"Am J Med Genet"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/795\/37\/50074025\/postgradmedj-68-37.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/795\/37\/50074025\/postgradmedj-68-37.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T14:29:45Z","timestamp":1682605785000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/68\/795\/37\/7062341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1,1]]},"references-count":18,"journal-issue":{"issue":"795","published-online":{"date-parts":[[1992,1,1]]},"published-print":{"date-parts":[[1992,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.68.795.37","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1992,1]]},"published":{"date-parts":[[1992,1,1]]}}}