{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T15:10:46Z","timestamp":1682608246919},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"796","license":[{"start":{"date-parts":[[1992,2,1]],"date-time":"1992-02-01T00:00:00Z","timestamp":696902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Individuals from the Asian sub-continent in the United Kingdom are at particular risk of developing osteomalacia. We report a Gujarati woman who developed osteomalacia whilst taking anticonvulsant drugs; withdrawal of anticonvulsant therapy was followed by a seizure complicated by femoral neck fracture.<\/jats:p>\n               <jats:p>In patients with other risk factors for osteomalacia, as is the case for Asians living in Britain, anticonvulsant drugs should not be reduced or withdrawn until osteomalacia, which puts the skeleton at increased risk of fracture, and its associated hypocalcaemia, which reduces seizure threshold, have been sought and adequately treated.<\/jats:p>","DOI":"10.1136\/pgmj.68.796.134","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"134-136","source":"Crossref","is-referenced-by-count":3,"title":["Osteomalacia should be sought and treated before withdrawal of anticonvulsant therapy in UK Asians"],"prefix":"10.1093","volume":"68","author":[{"given":"D C","family":"Macallan","sequence":"first","affiliation":[{"name":"Division of Biochemical Medicine, St. George's Hospital Medical School , Cranmer Terrace, London SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Division of Biochemical Medicine, St. George's Hospital Medical School , Cranmer Terrace, London SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J B","family":"Eastwood","sequence":"additional","affiliation":[{"name":"Division of Biochemical Medicine, St. George's Hospital Medical School , Cranmer Terrace, London SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,2,1]]},"reference":[{"issue":"4","key":"ref_1","first-page":"69","article-title":"Osteomalacia with long-term anticonvulsant therapy in epilepsy","volume":"1970","author":"Dent, C.E.; Richens, A.; Rowe, D.J.F.; Stamp, T.C.B.","unstructured":"Dent, C.E., Richens, A., Rowe, D.J.F. & Stamp, T.C.B. Osteomalacia with long-term anticonvulsant therapy in epilepsy. Br Med J 1970, 4: 69-72.","journal-title":"Br Med J"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1056\/NEJM197503132921102","article-title":"Serum 25-hydroxycalciferol levels and bone mass in children on chronic anticonvulsant therapy","volume":"292","author":"Hahn, T.J.; Hendin, B.A.; Scharp, C.R.; Boisseau, V.C.; Haddad, J.G.","year":"1975","unstructured":"Hahn, T.J., Hendin, B.A., Scharp, C.R., Boisseau, V.C. & Haddad, J.G. Serum 25-hydroxycalciferol levels and bone mass in children on chronic anticonvulsant therapy. N Engl J Med 1975, 292: 550-554.","journal-title":"N Engl J Med"},{"key":"ref_3","first-page":"433","article-title":"Effect of phenobarbitone treatment on vitamin D metabolism in mammals","volume":"46","author":"Silver, J.; Neale, G.; Thompson, G.R.","year":"1974","unstructured":"Silver, J., Neale, G. & Thompson, G.R. Effect of phenobarbitone treatment on vitamin D metabolism in mammals. Clin Sci Mol Med 1974, 46: 433-448.","journal-title":"Clin Sci Mol Med"},{"issue":"80","key":"ref_4","first-page":"425","article-title":"Anticonvulsant drugs and bone disease in the elderly","volume":"1987","author":"Harrington, M.G.; Hodkinson, H.M.","unstructured":"Harrington, M.G. & Hodkinson, H.M. Anticonvulsant drugs and bone disease in the elderly. J R Soc Med 1987, 80: 425-427.","journal-title":"J R Soc Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0221-8747(80)90002-8","article-title":"Effect of vitamin D3 (cholecalciferol) in anticonvulsant osteomalacia","volume":"2","author":"Eastwood, J.B.; Phillips, M.E.; de Wardener, H.E.","year":"1980","unstructured":"Eastwood, J.B., Phillips, M.E. & de Wardener, H.E. Effect of vitamin D3 (cholecalciferol) in anticonvulsant osteomalacia. Metab Bone Dis Rel Res 1980, 2: 83-86.","journal-title":"Metab Bone Dis Rel Res"},{"key":"ref_6","first-page":"1282","article-title":"Effect of chapattis and ultraviolet irradiation on nutritional rickets in Indian immigrants","volume":"i:","author":"Dent, C.E.; Round, J.M.; Rowe, D.J.F.; Stamp, T.C.B.","year":"1973","unstructured":"Dent, C.E., Round, J.M., Rowe, D.J.F. & Stamp, T.C.B. Effect of chapattis and ultraviolet irradiation on nutritional rickets in Indian immigrants. Lancet 1973, i: 1282-1284.","journal-title":"Lancet"},{"key":"ref_7","first-page":"413","article-title":"The importance of limited exposure to ultraviolet radiation and dietary factors in the aetiology of Asian rickets: a risk factor model","volume":"241","author":"Henderson, J.B.; Dunnigan, M.G.; McIntosh, W.B.; AbdulMotal, A.A.; Gettinby, G.; Glekin, B.M.","year":"1987","unstructured":"Henderson, J.B., Dunnigan, M.G., McIntosh, W.B., AbdulMotal, A.A., Gettinby, G. & Glekin, B.M. The importance of limited exposure to ultraviolet radiation and dietary factors in the aetiology of Asian rickets: a risk factor model. Q J Med 1987, 241: 413-425.","journal-title":"Q J Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1042\/cs0780383","article-title":"Detection of osteomalacia in British Asians: A comparison of clinical score with biochemical measurements","volume":"78","author":"Nisbet, J.A.; Eastwood, J.B.; Colston, K.W.","year":"1990","unstructured":"Nisbet, J.A., Eastwood, J.B., Colston, K.W. et al. Detection of osteomalacia in British Asians: A comparison of clinical score with biochemical measurements. Clin Sci 1990, 78: 383-389.","journal-title":"Clin Sci"},{"issue":"67","key":"ref_9","first-page":"536","article-title":"Bilateral fracture of the femoral neck during a hypocalcaemic convulsion","volume":"1985","author":"Taylor, L.J.; Grant, S.C.","unstructured":"Taylor, L.J. & Grant, S.C. Bilateral fracture of the femoral neck during a hypocalcaemic convulsion. J Bone Joint Surg 1985, 67: 536-537.","journal-title":"J Bone Joint Surg"},{"issue":"48","key":"ref_10","first-page":"117","article-title":"Complications after parathyroidectomy: fractures from low calcium and magnesium convulsions","volume":"1966","author":"Davies, D.R.; Friedman, M.","unstructured":"Davies, D.R. & Friedman, M. Complications after parathyroidectomy: fractures from low calcium and magnesium convulsions. J Bone Joint Surg [Br] 1966, 48B: 117-126.","journal-title":"J Bone Joint Surg [Br]"},{"key":"ref_11","first-page":"715","article-title":"Bone disease induced by anticonvulsant therapy and treatment with calcitriol (1,25-dihydroxyvitamin D3)","volume":"140","author":"Hunt, P.A.; Wu-chen, M.L.; Handal, N.J.","year":"1986","unstructured":"Hunt, P.A., Wu-chen, M.L., Handal, N.J. et al. Bone disease induced by anticonvulsant therapy and treatment with calcitriol (1,25-dihydroxyvitamin D3). Am J Dis Child 1986, 140: 715-718.","journal-title":"Am J Dis Child"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/796\/134\/50074039\/postgradmedj-68-134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/796\/134\/50074039\/postgradmedj-68-134.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T14:54:45Z","timestamp":1682607285000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/68\/796\/134\/7062285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2,1]]},"references-count":11,"journal-issue":{"issue":"796","published-online":{"date-parts":[[1992,2,1]]},"published-print":{"date-parts":[[1992,2,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.68.796.134","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1992,2]]},"published":{"date-parts":[[1992,2,1]]}}}