{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:16:09Z","timestamp":1769069769770,"version":"3.49.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"797","license":[{"start":{"date-parts":[[1992,3,1]],"date-time":"1992-03-01T00:00:00Z","timestamp":699408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,3,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>An association of bilateral large adrenocortical androgen-producing adenomas with polycystic ovaries in a young female is presented. She developed mild hirsutism and secondary amenorrhoea at the age of 17, and was treated for 3 years with an anti-androgen (cyproterone acetate) and ethinyloestradiol. Routine follow-up at the age of 21 showed bilateral large adrenal tumours and polycystic ovaries, together with high serum testosterone and dehydroepiandrosterone sulphate values. Bilateral adrenalectomy was performed, which resulted in lowering of the elevated androgens, and large bilateral adrenocortical adenomas were confirmed histologically. Contrary to expectations, the polycystic appearance of the ovaries persisted after adrenalectomy.<\/jats:p>\n               <jats:p>This case supports the possible role of adrenal androgens in the pathogenesis of polycystic ovaries as well as the possibility of the persistence of polycystic ovaries without adrenal androgens once they have developed.<\/jats:p>","DOI":"10.1136\/pgmj.68.797.219","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"219-222","source":"Crossref","is-referenced-by-count":7,"title":["Androgen-producing bilateral large cortical adrenal adenomas associated with polycystic ovaries in a young female"],"prefix":"10.1093","volume":"68","author":[{"given":"D","family":"Mici\u0107","sequence":"first","affiliation":[{"name":"Institute of Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Center , Belgrade, Yugoslavia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Zori\u0107","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Center , Belgrade, Yugoslavia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Popovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Center , Belgrade, Yugoslavia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Jankovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Center , Belgrade, Yugoslavia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Janci\u0107","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Center , Belgrade, Yugoslavia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Center , Belgrade, Yugoslavia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Manojlovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Center , Belgrade, Yugoslavia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Mi\u0107i\u0107","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Center , Belgrade, Yugoslavia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,3,1]]},"reference":[{"key":"ref_1","first-page":"670","article-title":"Androgen-produziererendes Nebennierenadenom bei einer 18 juhrigen Patientin: diagnostik mittels gaschromatographischer Steroidanalyse, Histologie und postoperativer Verlauf","volume":"94","author":"Vierhapper, H.; Nowotny, P.; Krisch, K.; Kletter, K.; Waldhausl, W.","year":"1982","unstructured":"Vierhapper, H., Nowotny, P., Krisch, K., Kletter, K. & Waldhausl, W. Androgen-produziererendes Nebennierenadenom bei einer 18 juhrigen Patientin: diagnostik mittels gaschromatographischer Steroidanalyse, Histologie und postoperativer Verlauf. Wien Klin Wochenschr 1982, 94: 670-673.","journal-title":"Wien Klin Wochenschr"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1056\/NEJM199011153232007","article-title":"Hormonal evaluation of the patient with an incidentally discovered adrenal mass","volume":"323","author":"Ross, N.S.; Aron, D.C.","year":"1990","unstructured":"Ross, N.S. & Aron, D.C. Hormonal evaluation of the patient with an incidentally discovered adrenal mass. N Engl J Med 1990, 323: 1401-1405.","journal-title":"N Engl J Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"940","DOI":"10.7326\/0003-4819-98-6-940","article-title":"The incidentally discovered adrenal mass","volume":"98","author":"Copeland, P.M.","year":"1983","unstructured":"Copeland, P.M. The incidentally discovered adrenal mass. Ann Intern Med 1983, 98: 940-945.","journal-title":"Ann Intern Med"},{"issue":"636","key":"ref_4","first-page":"1204","article-title":"Determination of the source(s) of androgen overproduction in hirsutism associated with polycystic ovary syndrome by simultaneous adrenal and ovarian venous catheterization. Comparison with the dexamethasone suppression test","volume":"1986","author":"Wajchenberg, B.L.; Achando, S.S.; Okada, H.","unstructured":"Wajchenberg, B.L., Achando, S.S., Okada, H. et al. Determination of the source(s) of androgen overproduction in hirsutism associated with polycystic ovary syndrome by simultaneous adrenal and ovarian venous catheterization. Comparison with the dexamethasone suppression test. J Clin Endocrinol Metab 1986, 636: 1204-1210.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_5","first-page":"2","article-title":"The role of the adrenal in polycystic ovary syndrome","volume":"1984","author":"Lobo, R.A.","unstructured":"Lobo, R.A. The role of the adrenal in polycystic ovary syndrome. Semin Reprod Endocrinol 1984, 2: 251-262.","journal-title":"Semin Reprod Endocrinol"},{"issue":"21","key":"ref_6","first-page":"1440","article-title":"Clinical assessment of body hair growth in women","volume":"1961","author":"Ferriman, D.; Gallwey, J.D.","unstructured":"Ferriman, D. & Gallwey, J.D. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961, 21: 1440-1447.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_7","first-page":"618","volume":"34","author":"Gerl, H.; Knappe, G.; Neumann, P.; Stahl, F.Androgenbildende Nebennierenrindentumoren Z.","year":"1979","unstructured":"Gerl, H., Knappe, G., Neumann, P. & Stahl, F. Androgenbildende Nebennierenrindentumoren. Z Gesamte Inn Med 1979, 34: 618-623.","journal-title":"Gesamte Inn Med"},{"issue":"55","key":"ref_8","first-page":"766","article-title":"Morphologic characteristics of benign and malignant adrenocortical tumors","volume":"1985","author":"Slooten, H.V.; Schaberg, A.; Smeenk, D.; Moolenaar, A.","unstructured":"Slooten, H.V., Schaberg, A., Smeenk, D. & Moolenaar, A. Morphologic characteristics of benign and malignant adrenocortical tumors. Cancer 1985, 55: 766-773.","journal-title":"Cancer"},{"issue":"318","key":"ref_9","first-page":"558","article-title":"Pathogenesis and treatment of polycystic ovary","volume":"1988","author":"McKenna, T.J.","unstructured":"McKenna, T.J. Pathogenesis and treatment of polycystic ovary. N Engi J Med 1988, 318: 558-562.","journal-title":"N Engi J Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/0002-9378(80)90095-2","article-title":"Adult manifestation of congenital adrenal hyperplasia due to incomplete 21hydroxylase deficiency mimicking polycystic ovarian disease","volume":"138","author":"Lobo, R.A.; Goebelsmann, U.","year":"1980","unstructured":"Lobo, R.A. & Goebelsmann, U. Adult manifestation of congenital adrenal hyperplasia due to incomplete 21hydroxylase deficiency mimicking polycystic ovarian disease. Am J Obstet Gynecol 1980, 138: 720-726.","journal-title":"Am J Obstet Gynecol"},{"issue":"44","key":"ref_11","first-page":"15","article-title":"In vitro production of androgens by a virilizing adrenal adenoma and associated polycystic ovaries","volume":"1963","author":"Kase, N.; Kowal, J.; Perloff, W.; Soffer, L.J.","unstructured":"Kase, N., Kowal, J., Perloff, W. & Soffer, L.J. In vitro production of androgens by a virilizing adrenal adenoma and associated polycystic ovaries. Acta Endocrinol 1963, 44: 15-19.","journal-title":"Acta Endocrinol"},{"issue":"62","key":"ref_12","first-page":"16","article-title":"Histopathological effects of exogenously administered testosterone in 19 female to male transexuals","volume":"1986","author":"Futterweit, W.; Deligdisch, I.","unstructured":"Futterweit, W. & Deligdisch, I. Histopathological effects of exogenously administered testosterone in 19 female to male transexuals. J Clin Endocrinol Metab 1986, 62: 16-21.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"386","DOI":"10.7326\/0003-4819-110-5-386","article-title":"The polycystic ovary syndrome: pathogenesis and treatment","volume":"110","author":"Barnes, R.; Rosenfield, R.L.","year":"1989","unstructured":"Barnes, R. & Rosenfield, R.L. The polycystic ovary syndrome: pathogenesis and treatment. Ann Intern Med 1989, 110: 386-399.","journal-title":"Ann Intern Med"},{"issue":"62","key":"ref_14","first-page":"142","article-title":"Adrenal abnormalities in polycystic ovary syndrome","volume":"1986","author":"Loughlin, T.; Cunningham, S.; Moore, A.; Culliton, M.; Smyth, P.P.A.; McKenna, T.J.","unstructured":"Loughlin, T., Cunningham, S., Moore, A., Culliton, M., Smyth, P.P.A. & McKenna, T.J. Adrenal abnormalities in polycystic ovary syndrome. J Clin Endocrinol Metab 1986,62: 142-147.","journal-title":"J Clin Endocrinol Metab"},{"issue":"50","key":"ref_15","first-page":"197","article-title":"The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism","volume":"1988","author":"Barbieri, R.L.; Smith, S.; Ryan, K.J.","unstructured":"Barbieri, R.L., Smith, S. & Ryan, K.J. The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism. 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