{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T06:10:22Z","timestamp":1682662222459},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"797","license":[{"start":{"date-parts":[[1992,3,1]],"date-time":"1992-03-01T00:00:00Z","timestamp":699408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,3,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>In this era of rapidly developing investigational tools and pharmacology, the pathophysiology of precocious puberty is becoming well defined. What was previously thought to be a form of gonadotrophin releasing hormone (GNRH)-dependent central precocious puberty is now classified as GNRH-independent familial testotoxicosis. We present two such cases and review the clinical features, pathophysiology and treatment of testotoxicosis.<\/jats:p>","DOI":"10.1136\/pgmj.68.797.225","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"225-228","source":"Crossref","is-referenced-by-count":2,"title":["Testotoxicosis: gonadotrophin-independent male sexual precocity"],"prefix":"10.1093","volume":"68","author":[{"given":"Arif Abdul","family":"Aziz","sequence":"first","affiliation":[{"name":"Department of Medicine, The Aga Khan University Hospital , Stadium Road, PO Box 3500, Karachi 74800, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M W","family":"Jafri","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Aga Khan University Hospital , Stadium Road, PO Box 3500, Karachi 74800, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naeem Ul","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Aga Khan University Hospital , Stadium Road, PO Box 3500, Karachi 74800, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1210\/jcem-71-4-785","article-title":"Pathophysiology and treatment of sexual precocity","volume":"71","author":"Kaplan, S.L.; Grumbach, M.M.","year":"1990","unstructured":"Kaplan, S.L. & Grumbach, M.M. Pathophysiology and treatment of sexual precocity. J Clin Endocrinol Metab 1990, 71: 785-789.","journal-title":"J Clin Endocrinol Metab"},{"issue":"52","key":"ref_2","first-page":"271","article-title":"Testicular Leydig cell hyperplasia as a cause of familial sexual precocity","volume":"1981","author":"Schedewie, H.K.; Reiter, E.O.; Beiten, I.Z.","unstructured":"Schedewie, H.K., Reiter, E.O., Beiten, I.Z. et al. Testicular Leydig cell hyperplasia as a cause of familial sexual precocity. J Clin Endocrinol Metab 1981, 52: 271-278.","journal-title":"J Clin Endocrinol Metab"},{"issue":"106","key":"ref_3","first-page":"33","article-title":"Pituitary gonadotrophin independent male limited autosomal dominant sexual precocity in nine generations: 'Familial Testotoxicosis'","volume":"1985","author":"Egli, C.A.; Rosenthal, S.M.; Grumbach, M.M.; Montalvo, J.M.; Gondos, B.","unstructured":"Egli, C.A., Rosenthal, S.M., Grumbach, M.M., Montalvo, J.M. & Gondos, B. Pituitary gonadotrophin independent male limited autosomal dominant sexual precocity in nine generations: 'Familial Testotoxicosis'. J Pediatr 1985, 106: 33-40.","journal-title":"J Pediatr"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJM198902233200805","article-title":"Treatment of familial male precocious puberty with spironolactone and testolactone","volume":"320","author":"Lave, L.; Keningsberg, D.; Percovitz, O.H.","year":"1989","unstructured":"Lave, L., Keningsberg, D., Percovitz, O.H. et al. Treatment of familial male precocious puberty with spironolactone and testolactone. N Engi J Med 1989, 320: 496-502.","journal-title":"N Engi J Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1210\/jcem-57-3-571","article-title":"Gonadotropin-independent familial sexual precocity with premature Leydig and germinal cell maturation (familial testotoxicosis): effects of a potent luteinizing hormone-releasing factor agonist and medroxy progesterone acetate therapy in four cases","volume":"57","author":"Rosenthal, S.M.; Grumbach, M.M.; Kaplan, S.L.","year":"1983","unstructured":"Rosenthal, S.M., Grumbach, M.M. & Kaplan, S.L. Gonadotropin-independent familial sexual precocity with premature Leydig and germinal cell maturation (familial testotoxicosis): effects of a potent luteinizing hormone-releasing factor agonist and medroxy progesterone acetate therapy in four cases. J Clin Endocrinol Metab 1983, 57: 571.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_6","first-page":"312","article-title":"Puberty without gonadotropins: a unique mechanism of sexual development","volume":"1985","author":"Wierman, M.E.; Beardsworth, D.E.; Mansfield, M.J.","unstructured":"Wierman, M.E., Beardsworth, D.E., Mansfield, M.J. et al. Puberty without gonadotropins: a unique mechanism of sexual development. N Engl J Med 1985, 312: 65-71.","journal-title":"N Engl J Med"},{"issue":"13","key":"ref_7","first-page":"174","article-title":"Familial constitutional precocious puberty in a boy three years of age: report of a case","volume":"1954","author":"Mortimer, Jr, E.A.","unstructured":"Mortimer, E.A., Jr. Familial constitutional precocious puberty in a boy three years of age: report of a case. Paediatrics 1954, 13: 174-177.","journal-title":"Paediatrics"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1146\/annurev.ph.44.030182.003115","article-title":"Neuroendocrine control mechanisms and the onset of puberty","volume":"44","author":"Reiter, E.O.; Grumbach, M.M.","year":"1982","unstructured":"Reiter, E.O. & Grumbach, M.M. Neuroendocrine control mechanisms and the onset of puberty. Ann Rev Physiol 1982, 44: 595.","journal-title":"Ann Rev Physiol"},{"issue":"109","key":"ref_9","first-page":"990","article-title":"Testicular changes in gonadotropin-independent familial male sexual precocity: familial testoxicosis","volume":"1985","author":"Gondos, B.; Egli, C.A.; Rosenthal, S.M.; Grumbach, M.M.","unstructured":"Gondos, B., Egli, C.A., Rosenthal, S.M. & Grumbach, M.M. Testicular changes in gonadotropin-independent familial male sexual precocity: familial testoxicosis. Arch Pathol Lab Med 1985, 109: 990-995.","journal-title":"Arch Pathol Lab Med"},{"key":"ref_10","first-page":"312","article-title":"Ketoconazole in the management of precocious puberty not responsive to LH RH therapy","volume":"1985","author":"Holland, F.J.; Fishman, L.; Bailey, J.D.; Fazekas, A.","unstructured":"Holland, F.J., Fishman, L., Bailey, J.D. & Fazekas, A. Ketoconazole in the management of precocious puberty not responsive to LH RH therapy. N Engl J Med 1985, 312: 1023-1028.","journal-title":"N Engl J Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1095\/biolreprod19.1.144","article-title":"Is there a local hormone from the seminiferous tubules affecting activity of Leydig cells?","volume":"19","author":"Aoki, A.; Fawcett, D.W.","year":"1987","unstructured":"Aoki, A. & Fawcett, D.W. Is there a local hormone from the seminiferous tubules affecting activity of Leydig cells? Biol Reprod 1987, 19: 144.","journal-title":"Biol Reprod"},{"issue":"24","key":"ref_12","first-page":"534","article-title":"Evaluation of leydig cell function and gonadotropin binding in unilateral and bilateral crytoorchidism: evidence for local control of Leydig cell function by seminiferous tubule","volume":"1981","author":"Risbridger, G.P.; Kerr, J.B.; De Krester, D.M.","unstructured":"Risbridger, G.P., Kerr, J.B. & De Krester, D.M. Evaluation of leydig cell function and gonadotropin binding in unilateral and bilateral crytoorchidism: evidence for local control of Leydig cell function by seminiferous tubule. Biol Reprod 1981, 24: 534.","journal-title":"Biol Reprod"},{"issue":"290","key":"ref_13","first-page":"785","article-title":"Sertoil leydig cell communication via LH RH like factor","volume":"1981","author":"Sharpe, R.M.; Fraser, H.M.; Cooper, I.; Rommerts, F.F.G.","unstructured":"Sharpe, R.M., Fraser, H.M., Cooper, I. & Rommerts, F.F.G. 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J Clin Invest 1981, 68: 306.","journal-title":"J Clin Invest"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1210\/jcem-57-4-732","article-title":"Site of action of low dose ketoconazole on androgen biosynthesis in men","volume":"57","author":"Santen, R.J.; Van den Bossche, H.; Symoens, J.","year":"1983","unstructured":"Santen, R.J., Van den Bossche, H., Symoens, J. et al., Site of action of low dose ketoconazole on androgen biosynthesis in men. J Clin Endocrinol Metab 1983, 57: 732-736.","journal-title":"J Clin Endocrinol Metab"},{"issue":"105","key":"ref_17","first-page":"275","article-title":"Effects of ketoconazole and other imidazole fungicides on testosterone biosynthesis","volume":"1984","author":"Schurmeyer, T.; Nieschleg, E.","unstructured":"Schurmeyer, T. & Nieschleg, E. Effects of ketoconazole and other imidazole fungicides on testosterone biosynthesis. Acta Endocrinol Copenh 1984, 105: 275-280.","journal-title":"Acta Endocrinol Copenh"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1210\/jcem-41-4-777","article-title":"Effect of spironolactone on sex hormones in man","volume":"41","author":"Stripp, B.; Taylor, A.A.; Bartter, F.C.","year":"1975","unstructured":"Stripp, B., Taylor, A.A., Bartter, F.C. et al. Effect of spironolactone on sex hormones in man. J Clin Endocrinol Metab 1975, 41: 777-781.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1210\/endo-94-6-1628","article-title":"Spironolactone and testicular cytochrome P- 450: decreased testosterone formation in several species and changes in hepatic drug metabolism","volume":"94","author":"Menard, R.H.; Stripp, G.; Gillete, J.R.","year":"1974","unstructured":"Menard, R.H., Stripp, G. & Gillete, J.R. 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Ann Int Med 1976, 85: 630-636.","journal-title":"Ann Int Med"},{"issue":"58","key":"ref_22","first-page":"717","article-title":"The effect of sex steroids on ulnar growth during adolescence","volume":"1984","author":"Cassorla, F.G.; Skerda, M.C.; Valk, I.M.","unstructured":"Cassorla, F.G., Skerda, M.C., Valk, I.M. et al. The effect of sex steroids on ulnar growth during adolescence. J Clin Endocrinol Metab 1984, 58: 717-720.","journal-title":"J Clin Endocrinol Metab"},{"issue":"61","key":"ref_23","first-page":"896","article-title":"Short term, low dose estradiol accelerates ulnar growth in boys","volume":"1985","author":"Caruso-Nicoletti, M.; Cassorla, F.; Skerda, M.","unstructured":"Caruso-Nicoletti, M., Cassorla, F., Skerda, M. et al. Short term, low dose estradiol accelerates ulnar growth in boys. J Clin Endocrinol Metab 1985, 61: 896-898.","journal-title":"J Clin Endocrinol Metab"},{"issue":"42","key":"ref_24","first-page":"443","volume":"1986","author":"Cutler, Jr, G.B.; Cassorla, F.G.; Ross, J.L.","unstructured":"Cutler, G.B., Jr, Cassorla, F.G., Ross, J.L. et al. Pubertal growth: Physiology and pathophysiology. Recent Prog Horm Res 1986, 42: 443-470.","journal-title":"et al. Pubertal growth: Physiology and pathophysiology. Recent Prog Horm Res"},{"issue":"15","key":"ref_25","first-page":"633","article-title":"Hormonal therapy in cancer of breast XIX. Effect of oral administration of testolactone on clinical course and hormonal excretion","volume":"1962","author":"Segaloff, A.; Wecth, J.B.; Meyer, K.K.","unstructured":"Segaloff, A., Wecth, J.B., Meyer, K.K. et al. Hormonal therapy in cancer of breast XIX. Effect of oral administration of testolactone on clinical course and hormonal excretion. Cancer 1962, 15: 633-635.","journal-title":"Cancer"},{"issue":"60","key":"ref_26","first-page":"773","article-title":"The effects of delta I -testolactone on gonadotropin release and steroid metabolism in polycystic ovarian disease","volume":"1985","author":"Dunaif, A.; Rongcope, C.; Carick, J.","unstructured":"Dunaif, A., Rongcope, C., Carick, J. et al. The effects of delta I -testolactone on gonadotropin release and steroid metabolism in polycystic ovarian disease. J Clin Endocrinol Metab 1985, 60: 773-780.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_27","first-page":"3327","article-title":"A new hypothesis based on suicide substrate inhibitol studies for the mechanism ofaction of aromatase","volume":"42","author":"Covey, D.F.; Hood, W.E.","year":"1982","unstructured":"Covey, D.F. & Hood, W.E. A new hypothesis based on suicide substrate inhibitol studies for the mechanism ofaction of aromatase. Cancer Res 1982, 42 (Suppl): 3327S-3333S.","journal-title":"Cancer Res"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/797\/225\/50074021\/postgradmedj-68-225.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/797\/225\/50074021\/postgradmedj-68-225.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T14:56:02Z","timestamp":1682607362000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/68\/797\/225\/7062292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3,1]]},"references-count":27,"journal-issue":{"issue":"797","published-online":{"date-parts":[[1992,3,1]]},"published-print":{"date-parts":[[1992,3,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.68.797.225","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1992,3]]},"published":{"date-parts":[[1992,3,1]]}}}