{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:42:03Z","timestamp":1760100123293},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"798","license":[{"start":{"date-parts":[[1992,4,1]],"date-time":"1992-04-01T00:00:00Z","timestamp":702086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Portal vein thrombosis is a rare complication of ulcerative colitis and is invariably fatal. This report describes a patient with severe Crohn's disease who underwent elective surgery complicated by an anastomotic disruption with faecal peritonitis. Following emergency laparotomy he developed left hypochondrial pain which was a manifestation of splenomegaly consequent upon portal vein thrombosis. Anticoagulation was successful in preventing further spread of the thrombosis as monitored by colour Doppler ultrasound. Severe active disease, surgery and sepsis have been recognized as predisposing factors for thromboembolic complications in inflammatory bowel disease and this patient was exposed to all three. It is conceivable that portal vein thromboses occur more commonly than suspected and ultrasound scanning could ascertain the prevalence if performed prospectively.<\/jats:p>","DOI":"10.1136\/pgmj.68.798.291","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"291-293","source":"Crossref","is-referenced-by-count":25,"title":["Portal vein thrombosis in a complicated case of Crohn's disease"],"prefix":"10.1093","volume":"68","author":[{"given":"A","family":"Crowe","sequence":"first","affiliation":[{"name":"Departments of Gastrointestinal Surgery, St Thomas' Hospital , London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Taffinder","sequence":"additional","affiliation":[{"name":"Departments of Gastrointestinal Surgery, St Thomas' Hospital , London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G T","family":"Layer","sequence":"additional","affiliation":[{"name":"Departments of Gastrointestinal Surgery, St Thomas' Hospital , London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Irvine","sequence":"additional","affiliation":[{"name":"Departments of Radiology, St Thomas' Hospital , London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Departments of Gastrointestinal Surgery, St Thomas' Hospital , London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,4,1]]},"reference":[{"key":"ref_1","first-page":"140","article-title":"Vascular complications of inflammatory bowel disease","volume-title":"Mayo Clin Proc 1986","volume":"61","author":"Talbot, R.W.; Heppell, J.; Dozois, R.R.; Beart, R.W.","unstructured":"Talbot, R.W., Heppell, J., Dozois, R.R. & Beart, R.W. Vascular complications of inflammatory bowel disease. Mayo Clin Proc 1986, 61: 140-145."},{"key":"ref_2","first-page":"2310","article-title":"Portal vein thrombosis in ulcerative colitis","volume":"71","author":"Aronson, A.R.; Steinheber, F.U.","year":"1971","unstructured":"Aronson, A.R. & Steinheber, F.U. Portal vein thrombosis in ulcerative colitis. NY State J Med 1971, 71: 2310-2311.","journal-title":"NY State J Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/BF01308436","article-title":"Gastrointestinal bleeding due to chronic portal vein thrombosis in ulcerative colitis","volume":"24","author":"Capron, J.P.; Remond, A.; Lebrec, D.; Delamarre, J.; Dupas, J.L.; Lorriaux, A.","year":"1979","unstructured":"Capron, J.P., Remond, A., Lebrec, D., Delamarre, J., Dupas, J.L. & Lorriaux, A. Gastrointestinal bleeding due to chronic portal vein thrombosis in ulcerative colitis. 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Br MedJ 1991, 302: 192-193.","journal-title":"Br MedJ"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1084\/jem.163.3.740","article-title":"Modulation of endothelial cell hemostatic properties by tumour necrosis factor","volume":"163","author":"Nawroth, P.P.; Stem, D.M.","year":"1986","unstructured":"Nawroth, P.P. & Stem, D.M. Modulation of endothelial cell hemostatic properties by tumour necrosis factor. J Exp Med 1986, 163: 740-745.","journal-title":"J Exp Med"},{"key":"ref_11","first-page":"301","article-title":"Tumour necrosis factor-alpha and interferongamma production measured at the single cell level in normal and inflamed human intestine. Clin Exp Immunol","volume":"81","author":"Macdonald, T.T.; Hutchings, P.; Choy, M.-Y.; Murch, S.; Cooke, A.","year":"1990","unstructured":"Macdonald, T.T., Hutchings, P., Choy, M.-Y., Murch, S. & Cooke, A. Tumour necrosis factor-alpha and interferongamma production measured at the single cell level in normal and inflamed human intestine. Clin Exp Immunol 1990, 81: 301-305."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1136\/bmj.300.6724.590","article-title":"Portal vein thrombosis in myeloproliferative disease","volume":"300","author":"Fidler, H.; Booth, A.; Hodgson, H.J.F.; Calam, J.; Luzatto, L.; Hughes, J.M.B.","year":"1990","unstructured":"Fidler, H., Booth, A., Hodgson, H.J.F., Calam, J., Luzatto, L. & Hughes, J.M.B. Portal vein thrombosis in myeloproliferative disease. 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