{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:48:42Z","timestamp":1761518922919},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"799","license":[{"start":{"date-parts":[[1992,5,1]],"date-time":"1992-05-01T00:00:00Z","timestamp":704678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,5,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Lipid metabolism was evaluated during management of phaeochromocytoma in a 41 year old non-obese post-menopausal women with familial combined hyperlipidaemia. The main effect of the excess catecholamine secretion on lipid metabolism was increased lipolytic activity, lower serum triglyceride and increased HDL cholesterol concentrations, compared with findings following removal of the tumour. Before removal of the tumour, the use of beta blockers alone led to marked deterioration of the hyperlipidaemic state, and combined \u03b1 and beta blockade additionally led to a marked reduction in fat oxidation and lipoprotein lipase activity. Overactivity of the adrenergic system leads to changes in lipid metabolism in phaeochromocytoma. Treatment of the phaeochromocytoma may lead to worsening of hyperlipidaemia pre-existing in such individuals.<\/jats:p>","DOI":"10.1136\/pgmj.68.799.371","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"371-375","source":"Crossref","is-referenced-by-count":6,"title":["Lipid and lipoprotein metabolism in familial combined hyperlipidaemia during treatment of sporadic phaeochromocytoma: a case study"],"prefix":"10.1093","volume":"68","author":[{"given":"Peter H","family":"Winocour","sequence":"first","affiliation":[{"name":"University of Newcastle upon Tyne Departments of Medicine , Framlington Place, Newcastle upon Tyne, NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahir","family":"Masud","sequence":"additional","affiliation":[{"name":"University of Newcastle upon Tyne Departments of Medicine , Framlington Place, Newcastle upon Tyne, NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Clark","sequence":"additional","affiliation":[{"name":"University of Newcastle upon Tyne Departments of Medicine , Framlington Place, Newcastle upon Tyne, NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan G","family":"Cooper","sequence":"additional","affiliation":[{"name":"University of Newcastle upon Tyne Departments of Medicine , Framlington Place, Newcastle upon Tyne, NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F","family":"Laker","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, The Medical School , Framlington Place, Newcastle upon Tyne, NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K George M M","family":"Alberti","sequence":"additional","affiliation":[{"name":"University of Newcastle upon Tyne Departments of Medicine , Framlington Place, Newcastle upon Tyne, NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1136\/bmj.284.6323.1145","article-title":"Adrenergic mechanisms in control of plasma lipid concentrations","volume":"284","author":"Day, J.L.; Metcalf, J.; Simpson, C.N.","year":"1982","unstructured":"Day, J.L., Metcalf, J. & Simpson, C.N. Adrenergic mechanisms in control of plasma lipid concentrations. Br Med J 1982, 284: 1145-1148.","journal-title":"Br Med J"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.0954-6820.1983.tb01612.x","article-title":"Adrenergic control of lipid metabolism","author":"Smith, U.","year":"1983","unstructured":"Smith, U. Adrenergic control of lipid metabolism. Acta Med Scand 1983, (Suppl 672): 41-47.","journal-title":"Acta Med Scand"},{"key":"ref_3","first-page":"146","article-title":"The effect of propanolol on total cholesterol, HDL cholesterol, triglycerides, postheparin lipolytic activity and lecithin:cholesterol acyltransferase in hypertensive individuals","volume":"8","author":"Schauer, I.; Schauer, U.; Ruhling, K.; Thielmen, K.","year":"1980","unstructured":"Schauer, I., Schauer, U., Ruhling, K. & Thielmen, K. 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