{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T01:34:29Z","timestamp":1773624869250,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"800","license":[{"start":{"date-parts":[[1992,6,1]],"date-time":"1992-06-01T00:00:00Z","timestamp":707356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We compared the clinical and serological characteristics of 15 patients with onset of systemic lupus erythematosus after the age of 50 with those of 232 younger patients. The sex distribution was similar in both groups. All 15 patients were Caucasian. Autoimmune thyroiditis was found in 20% of the elderly patients. Initial manifestations, which presented more frequently in the older group, included thrombocytopenia (P &amp;lt; 0.05), sicca syndrome (P &amp;lt; 0.01) and cardiomyopathy (P &amp;lt; 0.005), whereas butterfly rash (P &amp;lt; 0.05) presented more frequently in the younger group. Analysis of cumulative clinical symptoms showed that butterfly rash (P &amp;lt; 0.05) and livedo reticularis (P &amp;lt; 0.05) were less frequent in the elderly. However, this group presented a significantly increased incidence of sicca syndrome (P &amp;lt; 0.005) and cardiomyopathy (P &amp;lt; 0.005). Antibodies to double-stranded DNA tended to occur less frequently in older patients (P &amp;lt; 0.05).<\/jats:p>","DOI":"10.1136\/pgmj.68.800.440","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"440-444","source":"Crossref","is-referenced-by-count":43,"title":["Systemic lupus erythematosus in 50 year olds"],"prefix":"10.1093","volume":"68","author":[{"given":"I.","family":"Domenech","sequence":"first","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London, SE1 7HE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Aydintug","sequence":"additional","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London, SE1 7HE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cervera","sequence":"additional","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London, SE1 7HE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Khamashta","sequence":"additional","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London, SE1 7HE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Jedryka-Goral","sequence":"additional","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London, SE1 7HE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Vianna","sequence":"additional","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London, SE1 7HE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. R.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Lupus Arthritis Research Unit, The Rayne Institute, St Thomas' Hospital , London, SE1 7HE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,6,1]]},"reference":[{"issue":"64","key":"ref_1","first-page":"517","article-title":"Systemic lupus erythematosus","volume":"1988","author":"Hughes, G.R.V.","unstructured":"Hughes, G.R.V. Systemic lupus erythematosus. Postgrad Med J 1988, 64: 517-521.","journal-title":"Postgrad Med J"},{"issue":"14","key":"ref_2","first-page":"67","article-title":"Outcome and prognosis in systemic lupus erythematosus","volume":"1988","author":"Ginzler, E.M.; Schorn, K.","unstructured":"Ginzler, E.M. & Schorn, K. Outcome and prognosis in systemic lupus erythematosus. Rheum Clin Dis North Am 1988, 14: 67-78.","journal-title":"Rheum Clin Dis North Am"},{"issue":"24","key":"ref_3","first-page":"1230","article-title":"Age influences the clinical and serologic expression of systemic lupus erythematosus","volume":"1981","author":"Wilson, A.; Hamilton, M.E.; Spyker, D.A.","unstructured":"Wilson, A., Hamilton, M.E., Spyker, D.A. et al. Age influences the clinical and serologic expression of systemic lupus erythematosus. Arthritis Rheum 1981, 24: 1230-1235.","journal-title":"Arthritis Rheum"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/art.1780250109","article-title":"Clinical features of systemic lupus erythematosus. Differences related to race and age of onset","volume":"25","author":"Ballou, S.P.; Khan, M.A.; Kushner, I.","year":"1982","unstructured":"Ballou, S.P., Khan, M.A. & Kushner, I. Clinical features of systemic lupus erythematosus. Differences related to race and age of onset. Arthritis Rheum 1982, 25: 55-60.","journal-title":"Arthritis Rheum"},{"key":"ref_5","first-page":"175","article-title":"Systemic lupus erythematosus in the elderly: clinical and serological characteristics","volume":"11","author":"Catoggio, L.J.; Skinner, R.P.; Smith, G.; Maddison, P.J.","year":"1984","unstructured":"Catoggio, L.J., Skinner, R.P., Smith, G. & Maddison, P.J. Systemic lupus erythematosus in the elderly: clinical and serological characteristics. J Rheumatol 1984, 11: 175-181.","journal-title":"J Rheumatol"},{"key":"ref_6","first-page":"13","article-title":"Systemic lupus erythematosus in the elderly","volume":"14","author":"Maddison, P.J.","year":"1987","unstructured":"Maddison, P.J. Systemic lupus erythematosus in the elderly. J Rheumatol 1987, 14(Suppl 13): 182-187.","journal-title":"J Rheumatol"},{"issue":"15","key":"ref_7","first-page":"505","article-title":"The effect of age on clinical and serological manifestations in unselected patients with systemic lupus erythematosus","volume":"1988","unstructured":"Johnsson, H., Nived, 0. & Sturfelt, G. The effect of age on clinical and serological manifestations in unselected patients with systemic lupus erythematosus. J Rhewnatol 1988, 15: 505-509.","journal-title":"J Rhewnatol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1001\/archinte.1972.03650050067012","article-title":"Systemic lupus erythematosus in the elderly","volume":"130","author":"Foad, B.S.; Sheon, R.P.; Kirsner, A.B.","year":"1972","unstructured":"Foad, B.S., Sheon, R.P. & Kirsner, A.B. Systemic lupus erythematosus in the elderly. Arch Intern Med 1972, 130: 743-746.","journal-title":"Arch Intern Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/0002-9343(79)91109-4","article-title":"Late onset systemic lupus erythematosus","volume":"66","author":"Baker, S.B.; Rovira, J.R.; Campion, E.W.; Mills, J.A.","year":"1979","unstructured":"Baker, S.B., Rovira, J.R., Campion, E.W. & Mills, J.A. Late onset systemic lupus erythematosus. Am J Med 1979, 66: 727-732.","journal-title":"Am J Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/ard.50.10.702","article-title":"Systemic lupus erythematosus in elderly: clinical and serological characteristics","volume":"50","author":"Font, J.; Pallares, L.; Cervera, R.","year":"1991","unstructured":"Font, J., Pallares, L., Cervera, R. et al. Systemic lupus erythematosus in elderly: clinical and serological characteristics. Ann Rheum Dis 1991, 50: 702-705.","journal-title":"Ann Rheum Dis"},{"key":"ref_11","first-page":"319","article-title":"The influence of age on the clinical pattern of systemic lupus erythematosus","volume":"10","author":"Urowitz, M.B.; Stevens, M.B.; Shulman, L.E.","year":"1967","unstructured":"Urowitz, M.B., Stevens, M.B. & Shulman, L.E. The influence of age on the clinical pattern of systemic lupus erythematosus. Arthritis Rheum 1967, 10: 319-320.","journal-title":"Arthritis Rheum"},{"issue":"64","key":"ref_12","first-page":"285","article-title":"Systemic lupus erythematosus: a review of clinico-laboratory features and immunogenetic markers in 150 patients with emphasis on demographic subsets","volume":"1985","author":"Hochberg, M.C.; Boyd, R.E.; Ahearn, J.M.","unstructured":"Hochberg, M.C., Boyd, R.E., Ahearn, J.M. et al. Systemic lupus erythematosus: a review of clinico-laboratory features and immunogenetic markers in 150 patients with emphasis on demographic subsets. Medicine 1985, 64: 285-295.","journal-title":"Medicine"},{"key":"ref_13","first-page":"1271","article-title":"revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"Tan, E.M.; Cohen, A.S.; Fries, J.F.","year":"1982","unstructured":"Tan, E.M., Cohen, A.S., Fries, J.F. et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982, 25: 1271-1277.","journal-title":"et al. The"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/ard.46.1.1","article-title":"Anticardiolipin antibodies: isotype distribution and phospholipid specificity","volume":"46","author":"Gharavi, A.E.; Harris, E.N.; Asherson, R.A.; Hughes, G.R.V.","year":"1987","unstructured":"Gharavi, A.E., Harris, E.N., Asherson, R.A. & Hughes, G.R.V. Anticardiolipin antibodies: isotype distribution and phospholipid specificity. Ann Rheum Dis 1987, 46: 1-6.","journal-title":"Ann Rheum Dis"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3109\/00313027509081688","article-title":"Studies on phospholipids in the action of a lupus coagulation inhibitor","volume":"7","author":"Exner, T.; Rickard, K.A.; Kronenberg, H.","year":"1975","unstructured":"Exner, T., Rickard, K.A. & Kronenberg, H. Studies on phospholipids in the action of a lupus coagulation inhibitor. Pathology 1975, 7: 319-328.","journal-title":"Pathology"},{"key":"ref_16","first-page":"1193","article-title":"A prospective evaluation of antithyroid antibody prevalence in 100 patients with systemic lupus erythematosus","volume":"18","author":"Vianna, J.L.; Haga, H.J.; Asherson, R.A.; Swana, G.; Hughes, G.R.V.","year":"1991","unstructured":"Vianna, J.L., Haga, H.J., Asherson, R.A., Swana, G. & Hughes, G.R.V. A prospective evaluation of antithyroid antibody prevalence in 100 patients with systemic lupus erythematosus. J Rheunatol 1991, 18: 1193-1195.","journal-title":"J Rheunatol"},{"key":"ref_17","first-page":"557","article-title":"High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population.. Clin Exp Immunol","volume":"69","author":"Manoussakis, M.N.; Tzioufas, A.G.; Silis, M.G.; Pange, P.J.E.; Goudevenos, J.; Moutsopoulos, H.M.","year":"1987","unstructured":"Manoussakis, M.N., Tzioufas, A.G., Silis, M.G., Pange, P.J.E., Goudevenos, J. & Moutsopoulos, H.M. High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population.. Clin Exp Immunol 1987, 69: 557-565."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1001\/jama.1983.03330480056031","article-title":"Occult systemic lupus erythematosus in elderly men","volume":"249","author":"Baer, A.L.; Pincus, T.","year":"1983","unstructured":"Baer, A.L. & Pincus, T. Occult systemic lupus erythematosus in elderly men. JAMA 1983, 249: 3350-3352.","journal-title":"JAMA"},{"issue":"15","key":"ref_19","first-page":"723","article-title":"Systemic lupus erythematosus in the elderly. Is it really SLE or systemic Sj6gren's syndrome?","volume":"1988","author":"Bell, D.A.","unstructured":"Bell, D.A. Systemic lupus erythematosus in the elderly. Is it really SLE or systemic Sj6gren's syndrome? J Rheumatol 1988, 15: 723-724.","journal-title":"J Rheumatol"},{"key":"ref_20","first-page":"37","article-title":"Prognosis in systemic lupus erythematosus. Negative impact of increasing age at onset, black race, and thrombocytopenia, as well as causes of death","volume":"33","author":"Reveille, J.D.; Bartollucci, A.; Alarcon, G.A.","year":"1990","unstructured":"Reveille, J.D., Bartollucci, A. & Alarcon, G.A. Prognosis in systemic lupus erythematosus. Negative impact of increasing age at onset, black race, and thrombocytopenia, as well as causes of death. Arthritis Rheum 1990, 33: 37-48.","journal-title":"Arthritis Rheum"},{"issue":"12","key":"ref_21","first-page":"11","article-title":"Connective tissue disease in the elderly","volume":"1986","author":"Stevens, M.B.","unstructured":"Stevens, M.B. Connective tissue disease in the elderly. Clin Rheum Dis 1986, 12: 11-32.","journal-title":"Clin Rheum Dis"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/800\/440\/50074465\/postgradmedj-68-440.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/800\/440\/50074465\/postgradmedj-68-440.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T15:44:50Z","timestamp":1682610290000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/68\/800\/440\/7062449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6,1]]},"references-count":21,"journal-issue":{"issue":"800","published-online":{"date-parts":[[1992,6,1]]},"published-print":{"date-parts":[[1992,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.68.800.440","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1992,6]]},"published":{"date-parts":[[1992,6,1]]}}}