{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:40:41Z","timestamp":1709869241588},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"800","license":[{"start":{"date-parts":[[1992,6,1]],"date-time":"1992-06-01T00:00:00Z","timestamp":707356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,6,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A case of non-secretory multiple myeloma presenting as primary plasma cell leukaemia in a 65 year old woman is presented. Bone pain was the initial clinical manifestation. Laboratory analysis showed 20% of circulating immature plasma cells. Despite the presence of osteolytic lesions, no M-component could be demonstrated in serum protein electrophoresis, and serum and urine immunoelectrophoresis. Bone marrow aspirate demonstrated an 83% infiltration of plasma cells showing various degrees of immaturity. Immunofluorescence with monoclonal antisera demonstrated intracytoplasmic kappa light chains in a high percentage of plasma cells. Immature plasma cells without cellular capacity to synthesize and excrete complete immunoglobulins could be more aggressive, leading to an initial leukaemic process. Previous work regarding possible pathogenetic mechanisms, clinical and laboratory features, and response to treatment of this extremely rare association are reviewed.<\/jats:p>","DOI":"10.1136\/pgmj.68.800.470","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"470-472","source":"Crossref","is-referenced-by-count":2,"title":["Non-secretory multiple myeloma presenting as primary plasma cell leukaemia"],"prefix":"10.1093","volume":"68","author":[{"given":"A.","family":"Sureda","sequence":"first","affiliation":[{"name":"Departments of Haematology, Hospital Ramon y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Pais","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Hospital Ramon y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pascual","sequence":"additional","affiliation":[{"name":"Departments of Nephrology, Hospital Ramon y Cajal, Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"P\u00e9rez Vaquero","sequence":"additional","affiliation":[{"name":"Departments of Haematology, Hospital Ramon y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Hernando","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Hospital Ramon y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,6,1]]},"reference":[{"key":"ref_1","first-page":"29","volume":"869","author":"Kyle, R.A.Multiple myeloma","unstructured":"Kyle, R.A. Multiple myeloma. Review of 869 cases. Mayo Clin Proc 1975, 50: 29-40.","journal-title":"Review of; Mayo Clin Proc 1975"},{"key":"ref_2","first-page":"47","article-title":"Leukemic form of immunocytic dyscrasia (plasma cell leukemia). A study of ten cases and a review of the literature","volume":"1969","author":"Pruzanski, W.; Platts, M.E.; Ogrylzo, M.A.","unstructured":"Pruzanski, W., Platts, M.E. & Ogrylzo, M.A. Leukemic form of immunocytic dyscrasia (plasma cell leukemia). A study of ten cases and a review of the literature. 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