{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:40:28Z","timestamp":1709869228072},"reference-count":118,"publisher":"Oxford University Press (OUP)","issue":"801","license":[{"start":{"date-parts":[[1992,7,1]],"date-time":"1992-07-01T00:00:00Z","timestamp":709948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,7,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This review presents a critical evaluation of the role of Helicobacter pylori eradication in the management of peptic ulcer disease and non-ulcer dyspepsia. On current evidence, H. pylori eradication therapy seems likely to emerge as the most rational and cost-effective treatment for duodenal ulcer. The role of H. pylori eradication in the treatment of gastric ulcer and non-ulcer dyspepsia is unclear and requires further study. The emerging problem of antibiotic resistance in H. pylori is of major clinical importance and a prime cause of treatment failure. There is increasing evidence of a link between H. pylori and gastric cancer but it is premature to recommend large-scale eradication of H. pylori as a valid strategy for the primary prevention of gastric cancer. The search continues for the ideal H. pylori eradication regimen.<\/jats:p>","DOI":"10.1136\/pgmj.68.801.549","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"549-557","source":"Crossref","is-referenced-by-count":23,"title":["Eradication of<i>Helicobacter pylori<\/i>: therapies and clinical implications"],"prefix":"10.1093","volume":"68","author":[{"given":"Humphrey J","family":"O'Connor","sequence":"first","affiliation":[{"name":"General Hospital, Tullamore, County Offaly , Eire"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,7,1]]},"reference":[{"key":"ref_1","first-page":"1273","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis (letter)","volume":"i:","author":"Warren, J.R.; Marshall, B.","year":"1983","unstructured":"Warren, J.R. & Marshall, B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis (letter). Lancet 1983, i: 1273-1275.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1099\/00207713-39-4-397","article-title":"Transfer of Canpylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori comb. nov. and Helicobacter mustalae comb","volume":"39","author":"Goodwin, C.S.; Armstrong, J.A.; Chilvers, T.","year":"1989","unstructured":"Goodwin, C.S., Armstrong, J.A., Chilvers, T. et al. Transfer of Canpylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori comb. nov. and Helicobacter mustalae comb. nov., respectively. Int J Syst Bact 1989, 39: 397-405.","journal-title":"nov., respectively. Int J Syst Bact"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0016-5085(87)91028-6","article-title":"Gastric Campylobacter-like organisms, gastritis, and peptic ulcer disease","volume":"93","author":"Blaser, M.J.","year":"1987","unstructured":"Blaser, M.J., Gastric Campylobacter-like organisms, gastritis, and peptic ulcer disease. Gastroenterology 1987, 93: 371-383.","journal-title":"Gastroenterology"},{"issue":"108","key":"ref_4","first-page":"70","article-title":"The clinical significance of Campylobacter pylori","volume":"1988","author":"Dooley, C.P.; Cohen, H.","unstructured":"Dooley, C.P. & Cohen, H. The clinical significance of Campylobacter pylori. Ann Intern Med 1988, 108: 70-79.","journal-title":"Ann Intern Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1056\/NEJM199104113241507","article-title":"Helicobacter pylori and peptic ulcer disease","volume":"324","author":"Peterson, W.L.","year":"1991","unstructured":"Peterson, W.L. Helicobacter pylori and peptic ulcer disease. N Engl J Med 1991, 324: 1043-1048.","journal-title":"N Engl J Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1136\/adc.65.11.1278","article-title":"Helicobacter pylori","volume":"65","author":"Drumm, B.","year":"1990","unstructured":"Drumm, B. Helicobacter pylori. Arch Dis Child 1990, 65: 1278-1282.","journal-title":"Arch Dis Child"},{"issue":"1","key":"ref_7","first-page":"1311","article-title":"Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration","volume":"1984","author":"Marshall, B.J.; Warren, J.R.","unstructured":"Marshall, B.J. & Warren, J.R. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984, 1: 1311-1315.","journal-title":"Lancet"},{"key":"ref_8","first-page":"7","article-title":"Difference in relapse rates of duodenal ulcer after healing with cimetidine or tripotassium dicitrato bismuthate","volume":"i:","author":"Martin, D.F.; May, S.J.; Tweedle, D.E.F.; Hollanders, D.; Ravenscroft, M.M.; Miller, J.P.","year":"1981","unstructured":"Martin, D.F., May, S.J., Tweedle, D.E.F., Hollanders, D., Ravenscroft, M.M. & Miller, J.P. Difference in relapse rates of duodenal ulcer after healing with cimetidine or tripotassium dicitrato bismuthate. Lancet 1981, i: 7-10.","journal-title":"Lancet"},{"issue":"27","key":"ref_9","first-page":"106","article-title":"Healing and recurrence of duodenal ulcer after treatment with tripotassium dicitrato-bismuthate tablets or cimetidine","volume":"1986","author":"Hamilton, I.; O'Connor, H.J.; Wood, N.C.; Bradbury, I.; Axon, A.T.R.","unstructured":"Hamilton, I., O'Connor, H.J., Wood, N.C., Bradbury, I. & Axon, A.T.R. Healing and recurrence of duodenal ulcer after treatment with tripotassium dicitrato-bismuthate tablets or cimetidine. Gut 1986, 27: 106-110.","journal-title":"Gut"},{"key":"ref_10","first-page":"1299","article-title":"Comparison of tripotassium dicitrato bismuthate tablets with ranitidine in healing and relapse of duodenal ulcers","volume":"i:","author":"Lee, F.I.; Samloff, I.M.; Hardman, M.","unstructured":"Lee, F.I., Samloff, I.M. & Hardman, M. Comparison of tripotassium dicitrato bismuthate tablets with ranitidine in healing and relapse of duodenal ulcers. Lancet 1985, i: 1299-1302.","journal-title":"Lancet 1985"},{"key":"ref_11","first-page":"1048","article-title":"Double-blind short-term trial of furazolidone in peptic ulcer (letter)","volume":"i:","author":"Zheng, Z.-T.; Wang, Z.-Y.; Chu, Y.-X.","unstructured":"Zheng, Z.-T., Wang, Z.-Y., Chu, Y.-X. et al. Double-blind short-term trial of furazolidone in peptic ulcer (letter). Lancet 1985, i: 1048-1049.","journal-title":"Lancet 1985"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0140-6736(86)91006-8","article-title":"Metronidazole versus cimetidine in treatment of gastroduodenal ulcer (letter)","volume":"i:","author":"Quintero Diaz, M.; Sotto Escobar, A.","year":"1986","unstructured":"Quintero Diaz, M. & Sotto Escobar, A. Metronidazole versus cimetidine in treatment of gastroduodenal ulcer (letter). Lancet 1986, i: 907.","journal-title":"Lancet"},{"key":"ref_13","first-page":"1109","article-title":"Campylobacter pylori and recurrence of duodenal ulcers - a 12-month follow-up study","volume":"Hi:","author":"Coghlan, J.G.; Gilligan, D.; Humphries, H.","year":"1987","unstructured":"Coghlan, J.G., Gilligan, D., Humphries, H. et al. Campylobacter pylori and recurrence of duodenal ulcers - a 12-month follow-up study. Lancet 1987, Hi: 1109-1111.","journal-title":"Lancet"},{"issue":"1","key":"ref_14","first-page":"593","article-title":"Campylobacter pylori and ulcer recurrence (letter)","volume":"1988","author":"Bianchi Porro, G.; Lazzaroni, M.","unstructured":"Bianchi Porro, G. & Lazzaroni, M. Campylobacter pylori and ulcer recurrence (letter). Lancet 1988, 1: 593.","journal-title":"Lancet"},{"issue":"92","key":"ref_15","first-page":"1489","article-title":"Effect ofcolloidal bismuth (De-Nol) on healing and relapse of duodenal ulcers - role of Campylobacter pyloridis (abstract)","volume":"1987","author":"Lambert, J.R.; Borromeo, M.; Korman, M.G.; Hansky, J.; Eaves, E.R.","unstructured":"Lambert, J.R., Borromeo, M., Korman, M.G., Hansky, J. & Eaves, E.R. Effect ofcolloidal bismuth (De-Nol) on healing and relapse of duodenal ulcers - role of Campylobacter pyloridis (abstract). Gastroenterology 1987, 92 (Suppl): A1489.","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0140-6736(88)90929-4","article-title":"Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori","volume":"ii:","author":"Marshall, B.J.; Goodwin, C.S.; Warren, J.R.","year":"1988","unstructured":"Marshall, B.J., Goodwin, C.S., Warren, J.R. et al. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet 1988, ii: 1437-1442.","journal-title":"Lancet"},{"issue":"29","key":"ref_17","first-page":"71","article-title":"A comparison of ranitidine and tripotassium dicitratobismuth (TDB) in relapse rates of duodenal ulcer. The role of Campylobacter pylori","volume":"1988","author":"Smith, A.C.; Price, A.B.; Borriello, P.; Levi, A.J.","year":"1.","unstructured":"Smith, A.C., Price, A.B., Borriello, P. & Levi, A.J. A comparison of ranitidine and tripotassium dicitratobismuth (TDB) in relapse rates of duodenal ulcer. The role of Campylobacter pylori (CP) (abstract). Gut 1988, 29: A71 1.","journal-title":"(CP) (abstract). Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.5694\/j.1326-5377.1989.tb101251.x","article-title":"Recurrence of duodenal ulcer and Campylobacter pylori infection after eradication","volume":"151","author":"Borody, T.J.; Cole, P.; Noonan, S.","year":"1989","unstructured":"Borody, T.J., Cole, P., Noonan, S. et al. Recurrence of duodenal ulcer and Campylobacter pylori infection after eradication. Med J Aust 1989, 151: 431-435.","journal-title":"Med J Aust"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/0140-6736(91)93316-2","article-title":"Duodenal ulcer relapse after eradication of Helicobacterpylori (letter)","volume":"1","author":"Fiocca, R.; Solcia, E.; Santoro, B.","year":"1991","unstructured":"Fiocca, R., Solcia, E. & Santoro, B. Duodenal ulcer relapse after eradication of Helicobacterpylori (letter). Lancet 1991, 1: 1614.","journal-title":"Lancet"},{"key":"ref_20","first-page":"104","article-title":"Helicobacter pylori eradication prevents duodenal ulcer relapse (abstract)","volume":"100","author":"Lamouliatte, H.; Bernard, P.H.; Boulard, A.","year":"1991","unstructured":"Lamouliatte, H., Bernard, P.H., Boulard, A. et al. Helicobacter pylori eradication prevents duodenal ulcer relapse (abstract). Gastroenterology 1991, 100 (Suppl): A104.","journal-title":"Gastroenterology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0140-6736(90)91301-P","article-title":"Cure of duodenal ulcer associated with eradication of Helicobacter pylori","volume":"i:","author":"Rauws, E.A.J.; Tytgat, G.N.J.","year":"1990","unstructured":"Rauws, E.A.J. & Tytgat, G.N.J. Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet 1990, i: 1233-1235.","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.5694\/j.1326-5377.1990.tb136833.x","article-title":"Cure of duodenal ulcer after eradication ofHelicobacter pylori","volume":"153","author":"George, L.L.; Borody, T.J.; Andrews, P.","year":"1990","unstructured":"George, L.L., Borody, T.J., Andrews, P. et al. Cure of duodenal ulcer after eradication ofHelicobacter pylori. Med J Aust 1990, 153: 145-149.","journal-title":"Med J Aust"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1136\/bmj.284.6316.621","article-title":"Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate?","volume":"284","author":"Bardhan, K.D.; Cole, D.S.; Hawkins, B.W.; Franks, C.R.","year":"1982","unstructured":"Bardhan, K.D., Cole, D.S., Hawkins, B.W. & Franks, C.R. Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate? Br Med J 1982, 284: 621-623.","journal-title":"Br Med J"},{"issue":"1","key":"ref_24","first-page":"121","article-title":"The role of H. pylori eradication in the natural history of duodenal ulcer disease (abstract)","volume":"78","author":"Patchett, S.; Beattie, S.; Leen, E.; Keane, C.; O'Morain, C.","year":"1990","unstructured":"Patchett, S., Beattie, S., Leen, E., Keane, C. & O'Morain, C. The role of H. pylori eradication in the natural history of duodenal ulcer disease (abstract). Rev Esp EnfDigest 1990, 78 (Suppl 1): 121.","journal-title":"Rev Esp EnfDigest"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/jac\/17.3.309","article-title":"The minimum inhibitory and bactericidal concentrations of antibiotics and anti-ulcer agents against Campylobacter pyloridis","volume":"17","author":"Goodwin, C.S.; Blake, P.; Blincow, E.","year":"1986","unstructured":"Goodwin, C.S., Blake, P. & Blincow, E. The minimum inhibitory and bactericidal concentrations of antibiotics and anti-ulcer agents against Campylobacter pyloridis. J Antimicrob Chemother 1986, 17: 309-314.","journal-title":"J Antimicrob Chemother"},{"issue":"29","key":"ref_26","first-page":"894","article-title":"Epidermal growth factor (EGF) in the gastro-protective and ulcer healing actions of colloidal bismuth subcitrate (De-Nol) in rats","volume":"1988","author":"Konturek, S.J.; Dembinski, A.; Warzecha, Z.; Bielanski, W.; Brzozowski, T.; Drozdowicz, D.","unstructured":"Konturek, S.J., Dembinski, A., Warzecha, Z., Bielanski, W., Brzozowski, T. & Drozdowicz, D. Epidermal growth factor (EGF) in the gastro-protective and ulcer healing actions of colloidal bismuth subcitrate (De-Nol) in rats. Gut 1988, 29: 894-902.","journal-title":"Gut"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2036.1989.tb00188.x","article-title":"The absorption of bismuth from oral doses of tripotassium dicitrato bismuthate","volume":"3","author":"Nwokolo, C.U.; Gavey, C.J.; Smith, J.T.L.; Pounder, R.E.","year":"1989","unstructured":"Nwokolo, C.U., Gavey, C.J., Smith, J.T.L. & Pounder, R.E. The absorption of bismuth from oral doses of tripotassium dicitrato bismuthate. Aliment Pharmacol Therap 1989, 3: 29-39.","journal-title":"Aliment Pharmacol Therap"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1056\/NEJM199012133232405","article-title":"Histamine2-receptor antagonists: standard therapy for acid-peptic diseases","volume":"323","author":"Feldman, M.; Burton, M.E.","year":"1990","unstructured":"Feldman, M. & Burton, M.E. Histamine2-receptor antagonists: standard therapy for acid-peptic diseases. N Engl J Med 1990, 323: 1672-1680, 1749-1755.","journal-title":"N Engl J Med"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0140-6736(78)91200-X","article-title":"Maintenance treatment of recurrent peptic ulcer by cimetidine","volume":"i:","author":"Bodemar, G.; Walan, A.","year":"1978","unstructured":"Bodemar, G. & Walan, A. Maintenance treatment of recurrent peptic ulcer by cimetidine. Lancet 1978, i: 403-407.","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/gut.20.6.526","article-title":"Controlled trial of maintenance cimetidine treatment in healed duodenal ulcer: short and long-term effects","volume":"20","author":"Dronfield, M.W.; Batchelor, A.J.; Larkworthy, W.; Langman, M.J.S.","year":"1979","unstructured":"Dronfield, M.W., Batchelor, A.J., Larkworthy, W. & Langman, M.J.S. Controlled trial of maintenance cimetidine treatment in healed duodenal ulcer: short and long-term effects. Gut 1979, 20: 526-530.","journal-title":"Gut"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/gut.31.9.999","article-title":"Adjuvant antibiotic therapy in duodenal ulcers treated with colloidal bismuth subcitrate","volume":"31","author":"O'Riordan, T.; Mathai, E.; Tobin, E.","year":"1990","unstructured":"O'Riordan, T., Mathai, E., Tobin, E. et al. Adjuvant antibiotic therapy in duodenal ulcers treated with colloidal bismuth subcitrate. Gut 1990, 31: 999-1002.","journal-title":"Gut"},{"key":"ref_32","first-page":"36","article-title":"Helicobacterpylori: causal agent in peptic ulcer disease? Working Party Report of the World Congresses of Gastroenterology","author":"Tytgat, G.N.J.; Axon, A.T.R.; Dixon, M.F.; Graham, D.Y.; Lee, A.; Marshall, B.J.","year":"1990","unstructured":"Tytgat, G.N.J., Axon, A.T.R., Dixon, M.F., Graham, D.Y., Lee, A. & Marshall, B.J. Helicobacterpylori: causal agent in peptic ulcer disease? Working Party Report of the World Congresses of Gastroenterology. Blackwell Scientific Publications, Melbourne, 1990, pp. 36-45."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1136\/bmj.302.6782.919","article-title":"Duodenal ulcer: the villain unmasked?","volume":"302","author":"Axon, A.T.R.","year":"1991","unstructured":"Axon, A.T.R. Duodenal ulcer: the villain unmasked? Br Med J 1991, 302: 919-921.","journal-title":"Br Med J"},{"key":"ref_34","first-page":"1249","article-title":"One week eradication regimen for Helicobacter pylori","volume":"i:","author":"Logan, R.P.H.; Gummett, P.A.; Misiewicz, J.J.; Karim, Q.N.; Walker, M.M.; Baron, J.H.","year":"1991","unstructured":"Logan, R.P.H., Gummett, P.A., Misiewicz, J.J., Karim, Q.N., Walker, M.M. & Baron, J.H. One week eradication regimen for Helicobacter pylori. Lancet 1991, i: 1249-1252.","journal-title":"Lancet"},{"issue":"142","key":"ref_35","first-page":"436","article-title":"Attempt to fulfil Koch's postulates for pyloric campylobacter","volume":"1985","author":"Marshall, B.J.; Armstrong, J.A.; McGechie, D.B.; Glancy, R.J.","unstructured":"Marshall, B.J., Armstrong, J.A., McGechie, D.B. & Glancy, R.J. Attempt to fulfil Koch's postulates for pyloric campylobacter. Med J Aust 1985, 142: 436-444.","journal-title":"Med J Aust"},{"issue":"12","key":"ref_36","first-page":"1207","article-title":"DNA damage induced by reductively activated nitroimidazoles - pH effects","volume":"1986","author":"Edwards, D.I.; Knight, R.C.; Zahoor, A.","unstructured":"Edwards, D.I., Knight, R.C. & Zahoor, A. DNA damage induced by reductively activated nitroimidazoles - pH effects. Int J Radiat Oncol Biol Phys 1986, 12: 1207-1209.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref_37","first-page":"1409","article-title":"Gastric secretion of antibiotics used for Campylobacterpyloridis (abstract)","volume":"28","author":"Hollingworth, J.A.; Goldie, J.; Silletti, C.F.; Li, Y.; Richardson, H.; Hunt, R.H.","year":"1987","unstructured":"Hollingworth, J.A., Goldie, J., Silletti, C.F., Li, Y., Richardson, H. & Hunt, R.H. Gastric secretion of antibiotics used for Campylobacterpyloridis (abstract). Gut 1987, 28: A1409.","journal-title":"Gut"},{"issue":"41","key":"ref_38","first-page":"207","article-title":"Prevention of nitroimidazole resistance in Campylobacter pylori by coadministration of colloidal bismuth subcitrate: clinical and in vitro studies","volume":"1988","author":"Goodwin, C.S.; Marshall, B.J.; Blincow, E.D.; Wilson, D.H.; Blackbourn, S.; Phillips, M.","unstructured":"Goodwin, C.S., Marshall, B.J., Blincow, E.D., Wilson, D.H., Blackbourn, S. & Phillips, M. Prevention of nitroimidazole resistance in Campylobacter pylori by coadministration of colloidal bismuth subcitrate: clinical and in vitro studies. J Clin Pathol 1988, 41, 207-210.","journal-title":"J Clin Pathol"},{"key":"ref_39","first-page":"539","article-title":"Metronidazole-resistant Helicobacter pylori (letter)","volume":"i:","author":"Becz, M.C.J.M.; Janssen, A.J.H.M.; Clasener, H.A.L.; deKoning, R.W.","year":"1990","unstructured":"Becz, M.C.J.M., Janssen, A.J.H.M., Clasener, H.A.L. & deKoning, R.W. Metronidazole-resistant Helicobacter pylori (letter). Lancet 1990, i: 539-540.","journal-title":"Lancet"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/0140-6736(90)91043-A","article-title":"Metronidazole resistance in Helicobacter pylori (letter)","volume":"i:","author":"Glupczynski, Y.; Burette, A.; DeKoster, E.","year":"1990","unstructured":"Glupczynski, Y., Burette, A., DeKoster, E. et al. Metronidazole resistance in Helicobacter pylori (letter). Lancet 1990, i: 976-977.","journal-title":"Lancet"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1365-2036.1990.tb00513.x","article-title":"Helicobacter pylori infection treated with a tripotassium dicitrato bismuthate and metronidazole combination","volume":"4","author":"Weil, J.; Bell, G.D.; Powell, K.","year":"1990","unstructured":"Weil, J., Bell, G.D., Powell, K. et al. Helicobacter pylori infection treated with a tripotassium dicitrato bismuthate and metronidazole combination. Aliment Pharmacol Therap 1990, 4: 651-657.","journal-title":"Aliment Pharmacol Therap"},{"issue":"2","key":"ref_42","first-page":"110","article-title":"A treatment regimen for metronidazole-resistant Helicobacter pylori","volume":"23","author":"Logan, R.P.H.; Gummett, P.A.; Karim, Q.N.; Walker, M.M.; Baron, J.H.; Misiewicz, J.J.","year":"1991","unstructured":"Logan, R.P.H., Gummett, P.A., Karim, Q.N., Walker, M.M., Baron, J.H. & Misiewicz, J.J. A treatment regimen for metronidazole-resistant Helicobacter pylori (MRHP) (abstract). Ital J Gastroenterol 1991, 23 (Suppl 2): 110-111.","journal-title":"(MRHP) (abstract). Ital J Gastroenterol"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1056\/NEJM199104043241406","volume":"324","author":"Maton, P.N.Omeprazole","year":"1991","unstructured":"Maton, P.N. Omeprazole. N Engl J Med 1991, 324: 965-975.","journal-title":"N Engl J Med"},{"issue":"1","key":"ref_44","first-page":"118","article-title":"Antibacterial activity of pantoprozole, omeprazole, and other (H + \/K + ) ATPase inhibitors against Helicobacter pylori (abstract)","volume":"78","author":"Suerbaum, S.; Leying, H.; Hemmerle, B.; Klemm, K.; Opferkuch, W.","year":"1990","unstructured":"Suerbaum, S., Leying, H., Hemmerle, B., Klemm, K. & Opferkuch, W. Antibacterial activity of pantoprozole, omeprazole, and other (H + \/K + ) ATPase inhibitors against Helicobacter pylori (abstract). Rev Esp Enf Digest 1990, 78 (Suppl 1): 118.","journal-title":"Rev Esp Enf Digest"},{"key":"ref_45","first-page":"123","article-title":"Proton pump inhibitors have an antimicrobial activity against Helicobacter pylori (abstract)","volume":"100","author":"Megraud, F.; Bouchard, S.; Lamouliatte, H.","year":"1991","unstructured":"Megraud, F., Bouchard, S. & Lamouliatte, H. Proton pump inhibitors have an antimicrobial activity against Helicobacter pylori (abstract). Gastroenterology 1991, 100 (Suppl): A123.","journal-title":"Gastroenterology"},{"key":"ref_46","first-page":"389","article-title":"Campylobacter pylori, and duodenal ulcer (letter)","volume":"ii:","author":"Mainguet, P.; Delmee, M.; Debongnie, J.-C.Omeprazole","year":"1989","unstructured":"Mainguet, P., Delmee, M. & Debongnie, J.-C. Omeprazole, Campylobacter pylori, and duodenal ulcer (letter). Lancet 1989, ii: 389-390.","journal-title":"Lancet"},{"key":"ref_47","article-title":"Helicobacter pylori, gastritis, and duodenal ulcer (letter)","author":"Biasco, G.; Miglioli, M.; Barbara, L.; Corinaldesi, R.; diFebo, G.Omeprazole","year":"1989","unstructured":"Biasco, G., Miglioli, M., Barbara, L., Corinaldesi, R. & diFebo, G. Omeprazole, Helicobacter pylori, gastritis, and duodenal ulcer (letter). Lancet 1989, ii: 1403.","journal-title":"Lancet"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1365-2036.1991.tb00047.x","article-title":"The effect of omeprazole on Helicobacter pylori and associated gastritis","volume":"5","author":"Daw, M.A.; Deegan, P.; Leen, E.; O'Morain, C.","year":"1991","unstructured":"Daw, M.A., Deegan, P., Leen, E. & O'Morain, C. The effect of omeprazole on Helicobacter pylori and associated gastritis. Aliment Pharmacol Therap 1991, 5: 435-439.","journal-title":"Aliment Pharmacol Therap"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-2036.1991.tb00032.x","article-title":"Omeprazole and Helicobacterpylori: temporary suppression rather than true eradication","volume":"5","author":"Weil, J.; Bell, G.D.; Powell, K.","year":"1991","unstructured":"Weil, J., Bell, G.D., Powell, K. et al. Omeprazole and Helicobacterpylori: temporary suppression rather than true eradication. Aliment Pharmacol Therap 1991, 5: 309-313.","journal-title":"Aliment Pharmacol Therap"},{"key":"ref_50","first-page":"96","article-title":"Amoxycillin - omeprazole treatment for eradication of Helicobacter pylori (abstract)","volume":"78","author":"Labenz, J.; Gyenes, E.; Ruhl, G.H.; Borsch, G.","year":"1990","unstructured":"Labenz, J., Gyenes, E., Ruhl, G.H. & Borsch, G. Amoxycillin - omeprazole treatment for eradication of Helicobacter pylori (abstract). Rev Esp Enf Digest 1990, 78 (Suppl I): 96.","journal-title":"Rev Esp Enf Digest"},{"issue":"1","key":"ref_51","first-page":"101","article-title":"Controlled study of omeprazole - amoxicillin - tinidazole vs ranitidine - amoxicillin tinidazole in Helicobacterpylori. Associated duodenal ulcers preliminary results (abstract)","volume":"78","author":"Lamouliatte, H.; Bernard, P.H.; Boulard, A.; Megraud, F.; DeMascarel, A.; Quinton, A.","year":"1990","unstructured":"Lamouliatte, H., Bernard, P.H., Boulard, A., Megraud, F., DeMascarel, A. & Quinton, A. Controlled study of omeprazole - amoxicillin - tinidazole vs ranitidine - amoxicillin tinidazole in Helicobacterpylori. Associated duodenal ulcers preliminary results (abstract). Rev Esp Enf Digest 1990, 78 (Suppl 1): 101.","journal-title":"Rev Esp Enf Digest"},{"key":"ref_52","first-page":"52","article-title":"HP treatment; bismuth, omeprazole, antibiotics (abstract)","volume":"100","author":"De Koster, E.; Burette, A.; Nyst, J.F.","year":"1991","unstructured":"De Koster, E., Burette, A., Nyst, J.F. et al. HP treatment; bismuth, omeprazole, antibiotics (abstract). Gastroenterology 1991, 100 (Suppl): A52.","journal-title":"Gastroenterology"},{"key":"ref_53","first-page":"125","article-title":"Campylobacter pylori, gastric ulceration and the post-operative stomach","volume-title":"Campylobacter pylori and Gastroduodenal Disease","author":"O'Connor, H.J.; Axon, A.T.R.","year":"1989","unstructured":"O'Connor, H.J. & Axon, A.T.R. Campylobacter pylori, gastric ulceration and the post-operative stomach. In: Rathbone, B.J. & Heatley, R.V. (eds) Campylobacter pylori and Gastroduodenal Disease. Blackwell Scientific Publications, Oxford, 1989, pp. 125-138."},{"key":"ref_54","first-page":"973","article-title":"Reduction of gastric ulcer recurrence after suppression of Helicobacter pylori by cefixime","volume-title":"Gut","volume":"31","author":"Tatsuta, M.; Ishikawa, H.; lishi, H.; Okuda, S.; Yokota, Y.","year":"1990","unstructured":"Tatsuta, M., Ishikawa, H., lishi, H., Okuda, S. & Yokota, Y. Reduction of gastric ulcer recurrence after suppression of Helicobacter pylori by cefixime. Gut 1990, 31: 973-976."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0300-5089(21)00614-3","article-title":"Epidemiology of peptic ulcer disease","volume":"13","author":"Kurata, J.H.; Haile, B.M.","year":"1984","unstructured":"Kurata, J.H. & Haile, B.M. Epidemiology of peptic ulcer disease. Clin Gastroenterol 1984, 13: 289-307.","journal-title":"Clin Gastroenterol"},{"issue":"77","key":"ref_56","first-page":"8","article-title":"Health and economic aspects of peptic ulcer disease","volume":"1984","author":"Jensen, D.M.","unstructured":"Jensen, D.M. Health and economic aspects of peptic ulcer disease. Am J Med 1984, 77 (Suppl 5B): 8-14.","journal-title":"Am J Med"},{"key":"ref_57","first-page":"2","article-title":"The cost-effectiveness of maintenance therapy for duodenal ulceration with a H2antagonist","volume":"1988","author":"Fox, N.; Morton, R.E.; Jacobs, J.","unstructured":"Fox, N., Morton, R.E. & Jacobs, J. The cost-effectiveness of maintenance therapy for duodenal ulceration with a H2antagonist. Aliment Pharmacol Therap 1988, 2: 297-309.","journal-title":"Aliment Pharmacol Therap"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3109\/00365529108996487","article-title":"Cost-effectiveness of alternative medications in the treatment ofduodenal ulcer","volume":"26","author":"Ashton, T.","year":"1991","unstructured":"Ashton, T. Cost-effectiveness of alternative medications in the treatment ofduodenal ulcer. ScandJ Gastroenterol 1991, 26: 82-88.","journal-title":"ScandJ Gastroenterol"},{"issue":"108","key":"ref_59","first-page":"865","article-title":"Non-ulcer dyspepsia: potential causes and pathophysiology","volume":"1988","author":"Talley, N.J.; Phillips, S.F.","unstructured":"Talley, N.J. & Phillips, S.F. Non-ulcer dyspepsia: potential causes and pathophysiology. Ann Intern Med 1988, 108: 865-879.","journal-title":"Ann Intern Med"},{"key":"ref_60","first-page":"1306","article-title":"Non-ulcer dyspepsia","volume":"i:","author":"Editorial","year":"1986","unstructured":"Editorial. Non-ulcer dyspepsia. Lancet 1986, i: 1306-1307.","journal-title":"Lancet"},{"issue":"88","key":"ref_61","first-page":"1223","article-title":"Manometric evaluation of functional upper gut symptoms","volume":"1985","author":"Malagelada, J.R.; Stanghellini, V.","unstructured":"Malagelada, J.R. & Stanghellini, V. Manometric evaluation of functional upper gut symptoms. Gastroenterology 1985, 88: 1223-1231.","journal-title":"Gastroenterology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1136\/gut.28.2.131","article-title":"Intragastric bile acid concentrations are unrelated to symptoms of flatulent dyspepsia in patients with and without gall bladder disease and postcholecystectomy","volume":"28","author":"Watson, R.G.P.; Love, A.H.G.","year":"1987","unstructured":"Watson, R.G.P. & Love, A.H.G. Intragastric bile acid concentrations are unrelated to symptoms of flatulent dyspepsia in patients with and without gall bladder disease and postcholecystectomy. Gut 1987, 28: 131-136.","journal-title":"Gut"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0009-9260(82)80320-6","article-title":"Duodenogastric reflux in normal and dyspeptic subjects","volume":"33","author":"Hughes, K.; Robertson, D.A.R.; James, W.B.","year":"1982","unstructured":"Hughes, K., Robertson, D.A.R. & James, W.B. Duodenogastric reflux in normal and dyspeptic subjects. Clin Radiol 1982, 33: 461-466.","journal-title":"Clin Radiol"},{"issue":"35","key":"ref_64","first-page":"211","article-title":"Circulating gastrointestinal hormones in patients with flatulent dyspepsia, with and without gallbladder disease","volume":"1986","author":"Watson, R.G.P.; Shaw, C.; Buchanan, K.D.; Love, A.H.G.","unstructured":"Watson, R.G.P., Shaw, C., Buchanan, K.D. & Love, A.H.G. Circulating gastrointestinal hormones in patients with flatulent dyspepsia, with and without gallbladder disease. Digestion 1986, 35: 211-216.","journal-title":"Digestion"},{"issue":"90","key":"ref_65","first-page":"886","article-title":"Association of anxiety, neuroticism, and depression with dyspepsia of unknown cause. A case control study","volume":"1986","author":"Talley, N.J.; Fung, L.H.; Gilligan, I.J.; McNeil, D.; Piper, D.W.","unstructured":"Talley, N.J., Fung, L.H., Gilligan, I.J., McNeil, D. & Piper, D.W. Association of anxiety, neuroticism, and depression with dyspepsia of unknown cause. A case control study. Gastroenterology 1986, 90: 886-892.","journal-title":"Gastroenterology"},{"issue":"27","key":"ref_66","first-page":"127","article-title":"Major life event stress and dyspepsia of unknown cause: a case control study","volume":"1986","author":"Talley, N.J.; Piper, D.W.","unstructured":"Talley, N.J. & Piper, D.W. Major life event stress and dyspepsia of unknown cause: a case control study. Gut 1986, 27: 127-134.","journal-title":"Gut"},{"issue":"29","key":"ref_67","first-page":"1386","article-title":"Non-ulcer dyspepsia and short term De-Nol therapy: a placebo controlled trial with particular reference to the role of Campylobacterpylori","volume":"1988","author":"Rokkas, T.; Pursey, C.; Uzoechina, E.","unstructured":"Rokkas, T., Pursey, C., Uzoechina, E. et al. Non-ulcer dyspepsia and short term De-Nol therapy: a placebo controlled trial with particular reference to the role of Campylobacterpylori. Gut 1988, 29: 1386-1391.","journal-title":"Gut"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000200473","article-title":"Presence of Helicobacter pylori in patients with nonulcer dyspepsia revealing normal antral histological characteristics","volume":"47","author":"Loffeld, R.J.L.F.; Stobberingh, E.; Flendrig, J.A.; Arends, J.W.","year":"1990","unstructured":"Loffeld, R.J.L.F., Stobberingh, E., Flendrig, J.A. & Arends, J.W. Presence of Helicobacter pylori in patients with nonulcer dyspepsia revealing normal antral histological characteristics. Digestion 1990, 47: 29-34.","journal-title":"Digestion"},{"issue":"1","key":"ref_69","first-page":"70","article-title":"Non-ulcer dyspepsia symptoms and Helicobacter pylori (abstract)","volume":"78","author":"Timothy, T.; Schubert, M.D.","year":"1990","unstructured":"Timothy, T. & Schubert, M.D. Non-ulcer dyspepsia symptoms and Helicobacter pylori (abstract). Rev Esp EnfDigest 1990, 78 (Suppl 1): 70.","journal-title":"Rev Esp EnfDigest"},{"issue":"1","key":"ref_70","first-page":"68","article-title":"Clinicopathological correlations with Helicobacter pylori presence in dyspeptic patients (abstract)","volume":"78","author":"Gasbarrini, G.; Pretolani, S.; Bonvicini, F.","year":"1990","unstructured":"Gasbarrini, G., Pretolani, S., Bonvicini, F. et al. Clinicopathological correlations with Helicobacter pylori presence in dyspeptic patients (abstract). Rev Esp Enf Digest 1990, 78 (Suppl 1): 68.","journal-title":"Rev Esp Enf Digest"},{"issue":"1","key":"ref_71","first-page":"70","article-title":"Computerised history taking for the assessment of Helicobacterpylori in non-ulcer dyspepsia? A pilot study (abstract)","volume":"78","author":"Loffeld, R.J.L.F.; Adang, R.P.R.","year":"1990","unstructured":"Loffeld, R.J.L.F. & Adang, R.P.R. Computerised history taking for the assessment of Helicobacterpylori in non-ulcer dyspepsia? A pilot study (abstract). Rev Esp EnfDigest 1990, 78 (Suppl 1): 70-71.","journal-title":"Rev Esp EnfDigest"},{"key":"ref_72","first-page":"445","article-title":"Symptomatology of Helicobacter pylori - associated dyspepsia","volume":"2","author":"Sobala, G.M.; Dixon, M.F.; Axon, A.T.R.","year":"1990","unstructured":"Sobala, G.M., Dixon, M.F. & Axon, A.T.R. Symptomatology of Helicobacter pylori - associated dyspepsia. Eur J Gastroenterol Hepatol 1990, 2: 445-449.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref_73","first-page":"148","article-title":"Gastritis and Campylobacter pylori in healthy, asymptomatic volunteers","volume":"1988","author":"Barthel, J.S.; Westblom, U.; Havey, A.D.; Gonzalez, F.; Everett, E.D.","unstructured":"Barthel, J.S., Westblom, U., Havey, A.D., Gonzalez, F. & Everett, E.D. Gastritis and Campylobacter pylori in healthy, asymptomatic volunteers. Arch Intern Med 1988, 148: 1149-1151.","journal-title":"Arch Intern Med"},{"key":"ref_74","first-page":"192","article-title":"Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH","volume":"82","author":"Morris, A.; Nicholson, G.","year":"1987","unstructured":"Morris, A. & Nicholson, G. Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. Am J Gastroenterol 1987, 82: 192-199.","journal-title":"Am J Gastroenterol"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/0016-5085(79)90415-3","article-title":"Epidemic gastritis with hypochlorhydria","volume":"76","author":"Ramsey, E.J.; Carey, K.V.; Peterson, W.L.","year":"1979","unstructured":"Ramsey, E.J., Carey, K.V., Peterson, W.L. et al. Epidemic gastritis with hypochlorhydria. Gastroenterology 1979, 76: 1449-1457.","journal-title":"Gastroenterology"},{"issue":"293","key":"ref_76","first-page":"645","article-title":"Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate","volume":"1986","author":"McNulty, C.A.M.; Gearty, J.C.; Crump, B.","unstructured":"McNulty, C.A.M., Gearty, J.C., Crump, B. et al. Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate. Br Med J 1986, 293: 645-649.","journal-title":"Br Med J"},{"key":"ref_77","first-page":"7","article-title":"Campylobacter pylori - a role in non-ulcer dyspepsia?","volume":"160","author":"Lambert, J.R.; Dunn, K.; Borromeo, M.; Korman, M.G.; Hansky, J.","year":"1989","unstructured":"Lambert, J.R., Dunn, K., Borromeo, M., Korman, M.G. & Hansky, J. Campylobacter pylori - a role in non-ulcer dyspepsia? Scand J Gastroenterol 1989, 24 (Suppl 160): 7-13.","journal-title":"Scand J Gastroenterol"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1136\/gut.30.9.1206","article-title":"Campylobacter associated gastritis in patients with non-ulcer dyspepsia: a double blind placebo controlled trial with colloidal bismuth subcitrate","volume":"30","author":"Loffeld, R.J.L.F.; Potters, H.V.J.P.; Stobberingh, E.; Flendrig, J.A.; Van Spreeuwel, J.P.; Arends, J.W.","year":"1989","unstructured":"Loffeld, R.J.L.F., Potters, H.V.J.P., Stobberingh, E., Flendrig, J.A., Van Spreeuwel, J.P. & Arends, J.W. Campylobacter associated gastritis in patients with non-ulcer dyspepsia: a double blind placebo controlled trial with colloidal bismuth subcitrate. Gut 1989, 30: 1206-1212.","journal-title":"Gut"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/gut.31.4.476","article-title":"Effect of colloidal bismuth subcitrate on symptoms and gastric histology in non-ulcer dyspepsia. A double blind placebo controlled study","volume":"31","author":"Kang, J.Y.; Tay, H.H.; Wee, A.; Guan, R.; Math, M.V.; Yap, I.","year":"1990","unstructured":"Kang, J.Y., Tay, H.H., Wee, A., Guan, R., Math, M.V. & Yap, I. Effect of colloidal bismuth subcitrate on symptoms and gastric histology in non-ulcer dyspepsia. A double blind placebo controlled study. Gut 1990, 31: 476-480.","journal-title":"Gut"},{"issue":"1","key":"ref_80","first-page":"106","article-title":"The benefit of treating dyspeptic patients with normal endoscopic appearances (abstract)","volume":"78","author":"Vaira, D.; Holton, J.; Falzon, M.","year":"1990","unstructured":"Vaira, D., Holton, J., Falzon, M. et al. The benefit of treating dyspeptic patients with normal endoscopic appearances (abstract). Rev Esp Enf Digest 1990, 78 (Suppl 1): 106-107.","journal-title":"Rev Esp Enf Digest"},{"issue":"1","key":"ref_81","first-page":"114","article-title":"Helicobacter pylori and non ulcer dyspepsia. Results of a randomized double blind study amoxicillin vs placebo","volume":"78","author":"Ponderoux, P.; Amoyal, P.; Perez, C.","year":"1990","unstructured":"Ponderoux, P., Amoyal, P., Perez, C. et al. Helicobacter pylori and non ulcer dyspepsia. Results of a randomized double blind study amoxicillin vs placebo. Rev Esp Enf Digest 1990, 78 (Suppl 1): 114.","journal-title":"Rev Esp Enf Digest"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1136\/bmj.303.6812.1238","article-title":"Eradicating Helicobacter pylori and symptoms of non-ulcer dyspepsia","volume":"303","author":"Patchett, S.; Beattie, S.; Leen, E.; Keane, C.; O'Morain, C.","year":"1991","unstructured":"Patchett, S., Beattie, S., Leen, E., Keane, C. & O'Morain, C. Eradicating Helicobacter pylori and symptoms of non-ulcer dyspepsia. Br Med J 1991, 303: 1238-1240.","journal-title":"Br Med J"},{"key":"ref_83","first-page":"121","article-title":"Longterm effect of Helicobacter pylori eradication in non-ulcer dyspepsia (abstract)","volume":"100","author":"McCarthy, C.; Patchett, S.; Collins, R.; Beattie, S.; Keane, C.; O'Morain, C.","year":"1991","unstructured":"McCarthy, C., Patchett, S., Collins, R., Beattie, S., Keane, C. & O'Morain, C. Longterm effect of Helicobacter pylori eradication in non-ulcer dyspepsia (abstract). Gastroenterology 1991, 100 (Suppl): A121.","journal-title":"Gastroenterology"},{"key":"ref_84","first-page":"103","article-title":"Helicobacter pylori and gastric cancer: a review and hypothesis","volume":"4","author":"O'Connor, H.J.","year":"1992","unstructured":"O'Connor, H.J. Helicobacter pylori and gastric cancer: a review and hypothesis. Eur J Gastroenterol Hepatol 1992, 4: 103-109.","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"48","key":"ref_85","first-page":"3554","article-title":"A human model ofgastric carcinogenesis","volume":"1988","author":"Correa, P.","unstructured":"Correa, P. A human model ofgastric carcinogenesis. Cancer Res 1988, 48: 3554-3560.","journal-title":"Cancer Res"},{"key":"ref_86","first-page":"1","article-title":"Progress in the pathology of gastritis and duodenitis","volume-title":"Current Topics in Pathology Vol. 81. Gastrointestinal Pathology","author":"Dixon, M.F.","year":"1990","unstructured":"Dixon, M.F. Progress in the pathology of gastritis and duodenitis. In: Williams, G.T. (ed) Current Topics in Pathology Vol. 81. Gastrointestinal Pathology. SpringerVerlag, Berlin, 1990, pp. 1-40."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/BF01071995","article-title":"A reappraisal of the nature and significance of chronic atrophic gastritis","volume":"18","author":"Strickland, R.G.; Mackay, I.R.","year":"1972","unstructured":"Strickland, R.G. & Mackay, I.R. A reappraisal of the nature and significance of chronic atrophic gastritis. Am J Dig Dis 1972, 18: 426-440.","journal-title":"Am J Dig Dis"},{"key":"ref_88","first-page":"819","article-title":"The Gastrointestinal Physiology Working Group. Helicobacter pylori and gastritis in Peruvian patients: relationship to socioeconomic level, age and sex","volume":"85","year":"1990","unstructured":"The Gastrointestinal Physiology Working Group. Helicobacter pylori and gastritis in Peruvian patients: relationship to socioeconomic level, age and sex. Am J Gastroenterol 1990, 85: 819-823.","journal-title":"Am J Gastroenterol"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/infdis\/161.6.1237","article-title":"Seroprevalence of Helicobacter pylori infection in Thailand","volume":"161","author":"Perez-Perez, G.I.; Taylor, D.N.; Bodhidatta, L.","year":"1990","unstructured":"Perez-Perez, G.I., Taylor, D.N., Bodhidatta, L. et al. Seroprevalence of Helicobacter pylori infection in Thailand. J Infect Dis 1990, 161: 1237-1241.","journal-title":"J Infect Dis"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJM198706183162501","article-title":"Association of Campylobacter pylori on the gastric mucosa with antral gastritis in children","volume":"316","author":"Drumm, B.; Sherman, P.; Cutz, E.; Karmali, M.","year":"1987","unstructured":"Drumm, B., Sherman, P., Cutz, E. & Karmali, M. Association of Campylobacter pylori on the gastric mucosa with antral gastritis in children. N EngI J Med 1987, 316: 1557-1561.","journal-title":"N EngI J Med"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/bjc.1990.129","article-title":"Poor housing in childhood and high rates of stomach cancer in England and Wales","volume":"61","author":"Barker, D.J.P.; Coggon, D.; Osmond, C.; Wickham, C.","year":"1990","unstructured":"Barker, D.J.P., Coggon, D., Osmond, C. & Wickham, C. Poor housing in childhood and high rates of stomach cancer in England and Wales. Br J Cancer 1990, 61: 575-578.","journal-title":"Br J Cancer"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/gut.32.1.25","article-title":"Helicobacter pylori infection rates in relation to age and social class in a population of Welsh men","volume":"32","author":"Sitas, F.; Forman, D.; Yarnell, J.W.G.","year":"1991","unstructured":"Sitas, F., Forman, D., Yarnell, J.W.G. et al. Helicobacter pylori infection rates in relation to age and social class in a population of Welsh men. Gut 1991, 32: 25-28.","journal-title":"Gut"},{"key":"ref_93","first-page":"775","article-title":"Campylobacter pylori-associated gastritis and immune response in a population at increased risk of gastric carcinoma","volume":"84","author":"Fox, J.G.; Correa, P.; Taylor, N.S.","year":"1989","unstructured":"Fox, J.G., Correa, P., Taylor, N.S. et al. Campylobacter pylori-associated gastritis and immune response in a population at increased risk of gastric carcinoma. Am J Gastroenterol 1989, 84: 775-781.","journal-title":"Am J Gastroenterol"},{"issue":"40","key":"ref_94","first-page":"335","article-title":"The geography ofcancer ofthe stomach","volume":"1984","author":"Coggon, D.; Acheson, E.D.","unstructured":"Coggon, D. & Acheson, E.D. The geography ofcancer ofthe stomach. Br Med Bull 1984, 40: 335-341.","journal-title":"Br Med Bull"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/ijc.2910460410","article-title":"Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China","volume":"46","author":"Forman, D.; Sitas, F.; Newell, D.G.","year":"1990","unstructured":"Forman, D., Sitas, F., Newell, D.G. et al. Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China. Int J Cancer 1990, 46: 608-611.","journal-title":"Int J Cancer"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/bmj.302.6788.1302","article-title":"Association between infection with Helicobacterpyloriand risk ofgastric cancer: evidence from a prospective investigation","volume":"302","author":"Forman, D.; Newell, D.G.; Fullerton, F.","year":"1991","unstructured":"Forman, D., Newell, D.G., Fullerton, F. et al. Association between infection with Helicobacterpyloriand risk ofgastric cancer: evidence from a prospective investigation. Br Med J 1991, 302: 1302-1305.","journal-title":"Br Med J"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199110173251603","article-title":"Helicobacter pylori infection and the risk of gastric carcinoma","volume":"325","author":"Parsonnet, J.; Friedman, G.D.; Vandersteen, D.P.","year":"1991","unstructured":"Parsonnet, J., Friedman, G.D., Vandersteen, D.P. et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 1991, 325: 1127-1131.","journal-title":"N Engl J Med"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1056\/NEJM199110173251604","article-title":"Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii","volume":"325","author":"Nomura, A.; Stemmermann, G.N.; Chyou, P.-H.; Kato, I.; Perez-Perez, G.I.; Blaser, M.J.","year":"1991","unstructured":"Nomura, A., Stemmermann, G.N., Chyou, P.-H., Kato, I., Perez-Perez, G.I. & Blaser, M.J. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 1991, 325: 1132-1136.","journal-title":"N Engl J Med"},{"key":"ref_99","first-page":"\"65","article-title":"Ascorbate-nitrite reaction: possible means of blocking the formation of carcinogenic N-nitroso compounds","volume":"177","author":"Mirvish, S.S.; Wallcave, L.; Eagen, M.; Shubik, P.","year":"1972","unstructured":"Mirvish, S.S., Wallcave, L., Eagen, M. & Shubik, P. Ascorbate-nitrite reaction: possible means of blocking the formation of carcinogenic N-nitroso compounds. Science 1972, 177: 65-68. Ohshima, H. & Bartsch, H. Quantitative estimation of endogenous nitrosation in humans by monitoring Nnitrosoproline excreted in the urine. Cancer Res 1981, 41: 3658-3662.","journal-title":"Science; Quantitative estimation of endogenous nitrosation in humans by monitoring Nnitrosoproline excreted in the urine"},{"key":"ref_100","first-page":"631","article-title":"The etiology of gastric cancer: intragastric nitrosamide formation and other theories","volume":"71","author":"Mirvish, S.S.","year":"1983","unstructured":"Mirvish, S.S. The etiology of gastric cancer: intragastric nitrosamide formation and other theories. J Nati Cancer Inst 1983, 71: 631-647.","journal-title":"J Nati Cancer Inst"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/gut.30.4.436","article-title":"Vitamin C in the human stomach: relation to gastric pH, gastroduodenal disease, and possible sources","volume":"30","author":"O'Connor, H.J.; Schorah, C.J.; Habibzedah, N.; Axon, A.T.R.; Cockel, R.","year":"1989","unstructured":"O'Connor, H.J., Schorah, C.J., Habibzedah, N., Axon, A.T.R. & Cockel, R. Vitamin C in the human stomach: relation to gastric pH, gastroduodenal disease, and possible sources. Gut 1989, 30: 436-442.","journal-title":"Gut"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1042\/cs0760237","article-title":"Ascorbic acid: a factor concentrated in human gastric juice","volume":"76","author":"Rathbone, B.J.; Johnson, A.W.; Wyatt, J.I.; Kelleher, J.; Heatley, R.V.; Losowsky, M.S.","year":"1989","unstructured":"Rathbone, B.J., Johnson, A.W., Wyatt, J.I., Kelleher, J, Heatley, R.V. & Losowsky, M.S. Ascorbic acid: a factor concentrated in human gastric juice. Clin Sci 1989, 76: 237-241.","journal-title":"Clin Sci"},{"key":"ref_103","first-page":"357","volume":"97","author":"Sobala, G.M.; Schorah, C.J.; Sanderson, M.","unstructured":"Sobala, G.M., Schorah, C.J., Sanderson, M. et al. Ascorbic acid in the human stomach. Gastroenterology 1989, 97: 357-363.","journal-title":"et al. Ascorbic; acid in the human stomach. Gastroenterology 1989"},{"key":"ref_104","first-page":"69","article-title":"Gastric juice 'secretion'","volume-title":"of ascorbic acid (abstract). Proc Nutr Soc 1986","volume":"45","author":"Rathbone, B.J.; Johnson, A.W.; Jones, C.; Kelleher, J.; Heatley, R.V.","unstructured":"Rathbone, B.J., Johnson, A.W., Jones, C., Kelleher, J. & Heatley, R.V. Gastric juice 'secretion' of ascorbic acid (abstract). Proc Nutr Soc 1986, 45: 69."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1136\/gut.32.11.1415","article-title":"Acute Helicobacter pylori infection: clinical features, local and systemic immune response, gastric mucosal histology, and gastric juice ascorbic acid concentrations","volume":"32","author":"Sobala, G.M.; Crabtree, J.E.; Dixon, M.F.","year":"1991","unstructured":"Sobala, G.M., Crabtree, J.E., Dixon, M.F. et al. Acute Helicobacter pylori infection: clinical features, local and systemic immune response, gastric mucosal histology, and gastric juice ascorbic acid concentrations. Gut 1991, 32: 1415-1418.","journal-title":"Gut"},{"issue":"29","key":"ref_106","first-page":"909","article-title":"Campylobacterpylori in a sample of Finnish population: relations to morphology and functions of the gastric mucosa","volume":"1988","author":"Siurala, M.; Sipponen, P.; Kekki, M.","unstructured":"Siurala, M., Sipponen, P. & Kekki, M. Campylobacterpylori in a sample of Finnish population: relations to morphology and functions of the gastric mucosa. Gut 1988, 29: 909-915.","journal-title":"Gut"},{"key":"ref_107","first-page":"139","article-title":"The effects of the sustained and profound inhibition of gastric acid production on gut flora","volume":"12","author":"Leach, S.A.; Hill, M.J.","year":"1990","unstructured":"Leach, S.A. & Hill, M.J. The effects of the sustained and profound inhibition of gastric acid production on gut flora. Res Clin Forums 1990, 12: 139-151.","journal-title":"Res Clin Forums"},{"key":"ref_108","first-page":"1037","article-title":"Gastricjuice nitrite: a risk factor for cancer in the hypochlorhydric stomach?","volume":"ii:","author":"Ruddell, W.S.J.; Bone, E.S.; Blendis, L.M.; Walters, C.L.","year":"1976","unstructured":"Ruddell, W.S.J., Bone, E.S., Blendis, L.M. & Walters, C.L. Gastricjuice nitrite: a risk factor for cancer in the hypochlorhydric stomach? Lancet 1976, ii: 1037-1039.","journal-title":"Lancet"},{"key":"ref_109","first-page":"209","article-title":"An improved method for analysis of total N-nitroso compounds in gastric juice","volume":"84","author":"Pignatelli, B.; Richard, I.; Bourgade, M.-C.; Bartsch, H.","year":"1987","unstructured":"Pignatelli, B., Richard, I., Bourgade, M.-C. & Bartsch, H. An improved method for analysis of total N-nitroso compounds in gastric juice. In: Bartsch, H., O'Neill, I. & Schulte-Herman, R. (eds) The Relevance ofN-nitroso Compounds to Human Cancer. IARC Scientific Publication No. 84. International Agency for Research on Cancer, Lyon, 1987, pp. 209-215.","journal-title":"IARC Scientific Publication; The Relevance ofN-nitroso Compounds to Human Cancer"},{"key":"ref_110","first-page":"3","article-title":"Proliferation and differentiation of gastrointestinal cells in health and disease","author":"Ill. Deschner, E.E.; Lipkin, M.","year":"1978","unstructured":"Ill. Deschner, E.E. & Lipkin, M. Proliferation and differentiation of gastrointestinal cells in health and disease. In: Lipkin, M. & Good, R.A. (eds) Gastrointestinal Tract Cancer. Plenum Medical Books, New York, 1978, pp. 3-24."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/jcp.33.9.801","article-title":"Role of intestinal metaplasia in the histogenesis of gastric cancer","volume":"33","author":"Jass, J.R.","year":"1980","unstructured":"Jass, J.R. Role of intestinal metaplasia in the histogenesis of gastric cancer. J Clin Pathol 1980, 33: 801-810.","journal-title":"J Clin Pathol"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/gut.33.1.16","article-title":"Intestinal metaplasia and Helicobacter pylori: an endoscopic bioptic study of the gastric antrum","volume":"33","author":"Craanen, M.E.; Dekker, W.; Blok, P.; Ferwerda, J.; Tytgat, G.N.J.","year":"1992","unstructured":"Craanen, M.E., Dekker, W., Blok, P., Ferwerda, J. & Tytgat, G.N.J. Intestinal metaplasia and Helicobacter pylori: an endoscopic bioptic study of the gastric antrum. Gut 1992, 33: 16-20.","journal-title":"Gut"},{"issue":"22","key":"ref_113","first-page":"163","article-title":"The sex ratio in gastric cancer and hypothetical considerations relative to aetiology","volume":"1968","author":"Griffith, G.W.","unstructured":"Griffith, G.W. The sex ratio in gastric cancer and hypothetical considerations relative to aetiology. Br J Cancer 1968, 22: 163-172.","journal-title":"Br J Cancer"},{"key":"ref_114","first-page":"859","article-title":"Gastric cancer: relationships between ABO blood groups, site, and epidemiology","volume":"ii:","author":"Billington, B.P.","unstructured":"Billington, B.P. Gastric cancer: relationships between ABO blood groups, site, and epidemiology. Lancet 1956, ii: 859-862.","journal-title":"Lancet 1956"},{"key":"ref_115","first-page":"765","article-title":"Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo","volume":"i:","author":"Yokota, J.; Yamamoto, T.; Toyoshima, K.","unstructured":"Yokota, J., Yamamoto, T., Toyoshima, K. et al. Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo. Lancet 1986, i: 765-767.","journal-title":"Lancet 1986"},{"issue":"5","key":"ref_116","first-page":"1641","article-title":"Correlation between 06-methylguanineDNA-methyltransferase activity and resistance of human celis to the cytotoxic and mutagenic effect of N-methyl-N'nitro-N-nitrosoguanidine","volume":"1984","author":"Domoradzki, J.; Pegg, A.E.; Dolan, M.E.; Maher, V.M.; McCormick, J.J.","unstructured":"Domoradzki, J., Pegg, A.E., Dolan, M.E., Maher, V.M. & McCormick, J.J. Correlation between 06-methylguanineDNA-methyltransferase activity and resistance of human celis to the cytotoxic and mutagenic effect of N-methyl-N'nitro-N-nitrosoguanidine. Carcinogenesis 1984, 5: 1641-1647.","journal-title":"Carcinogenesis"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/carcin\/4.7.879","article-title":"Location of N-methyl-N'-nitro-N-nitrosoguanidine-induced gastrointestinal tumours correlates with thiol distribution","volume":"4","year":"1983","unstructured":"Location of N-methyl-N'-nitro-N-nitrosoguanidine-induced gastrointestinal tumours correlates with thiol distribution. Carcinogenesis 1983, 4: 879-883.","journal-title":"Carcinogenesis"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1440-1746.1991.tb01451.x","article-title":"Helicobacter pylori and peptic ulceration: histopathological aspects","volume":"6","author":"Dixon, M.F.","year":"1991","unstructured":"Dixon, M.F. Helicobacter pylori and peptic ulceration: histopathological aspects. J Gastroenterol Hepatol 1991, 6: 125-130.","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/801\/549\/50074267\/postgradmedj-68-549.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/801\/549\/50074267\/postgradmedj-68-549.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:06:25Z","timestamp":1709867185000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/68\/801\/549\/7062391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7,1]]},"references-count":118,"journal-issue":{"issue":"801","published-online":{"date-parts":[[1992,7,1]]},"published-print":{"date-parts":[[1992,7,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.68.801.549","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1992,7]]},"published":{"date-parts":[[1992,7,1]]}}}