{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:24:53Z","timestamp":1760783093163},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"802","license":[{"start":{"date-parts":[[1992,8,1]],"date-time":"1992-08-01T00:00:00Z","timestamp":712627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>During a 3 year period, 1987-1989, we encountered three major complications associated with parenteral nutrition leading to congestive cardiac failure--acute beriberi, right atrial and superior vena caval thrombosis, and fungal endocarditis. Unrecognized, these are invariably fatal. Persistent vomiting from intestinal obstruction led to the development of thiamine deficiency in the patient with beriberi. Recurrent catheter tip sepsis probably accounted for thrombosis and endocarditis in the second and third cases, respectively. These conditions are preventable with careful attention to nutritional replenishment and aseptic technique. In patients with catheter-related sepsis early, repeated blood culture is of diagnostic value. Patients with Staphylococcus aureus catheter-associated bacteraemia require at least 4 weeks of appropriate antibiotic therapy. Recurrent sepsis, especially when associated with pulmonary embolic phenomena, is an indication for echocardiography.<\/jats:p>","DOI":"10.1136\/pgmj.68.802.629","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"629-633","source":"Crossref","is-referenced-by-count":12,"title":["Cardiovascular complications of parenteral nutrition"],"prefix":"10.1093","volume":"68","author":[{"given":"Datshana P","family":"Naidoo","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Natal , Durban, Republic of South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Natal , Durban, Republic of South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Haffejee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Natal , Durban, Republic of South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,8,1]]},"reference":[{"key":"ref_1","first-page":"239","article-title":"Beriberi can complicate TPN","volume":"45","author":"Anon","year":"1987","unstructured":"Anon. Beriberi can complicate TPN. Nutr Rev 1987, 45: 239-243.","journal-title":"Nutr Rev"},{"issue":"10","key":"ref_2","first-page":"102","article-title":"Shoshin beriberi: an unusual complication of prolonged parenteral nutrition","volume":"1986","author":"La Selve, P.; Domolin, P.; Holzapfel, L.; Blanc, P.L.; Teyssier, G.; Robert, D.","unstructured":"La Selve, P., Domolin, P., Holzapfel, L., Blanc, P.L., Teyssier, G. & Robert, D. Shoshin beriberi: an unusual complication of prolonged parenteral nutrition. JPEN J Parenter Enteral Nutr 1986, 10: 102-103.","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"9","key":"ref_3","first-page":"216","article-title":"Severe acute metabolic acidosis (acute beriberi): an avoidable complication of total parenteral nutrition","volume":"1985","author":"Velez, R.J.; Myers, B.; Guber, M.S.","unstructured":"Velez, R.J., Myers, B. & Guber, M.S. Severe acute metabolic acidosis (acute beriberi): an avoidable complication of total parenteral nutrition. JPEN J Parenter Enteral Nutr 1985, 9: 216-219.","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"14","key":"ref_4","first-page":"384","article-title":"Thiamine deficiency in the critically ill","volume":"1988","author":"Cruickshank, A.M.; Telfer, A.B.M.; Shenkin, A.","unstructured":"Cruickshank, A.M., Telfer, A.B.M. & Shenkin, A. Thiamine deficiency in the critically ill. Intensive Care Med, 1988, 14: 384-387.","journal-title":"Intensive Care Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1001\/archinte.1989.00390030009002","article-title":"Preventing second-generation complications due to Staphylococcus aureus","volume":"149","author":"Rahal, J.J.","year":"1989","unstructured":"Rahal, J.J. Preventing second-generation complications due to Staphylococcus aureus. Arch Int Med 1989, 149: 503-504.","journal-title":"Arch Int Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1056\/NEJM198411013111804","article-title":"Right-sided infective endocarditis as a consequence of flowdirected pulmonary artery catheter: a clinicopathological study of 55 patients autopsied","volume":"311","author":"Rosley, K.M.; Clubb, K.S.; Smith, G.J.W.; Cabin, M.S.","year":"1984","unstructured":"Rosley, K.M., Clubb, K.S., Smith, G.J.W. & Cabin, M.S. Right-sided infective endocarditis as a consequence of flowdirected pulmonary artery catheter: a clinicopathological study of 55 patients autopsied. N Engi J Med 1984, 311: 1152-1156.","journal-title":"N Engi J Med"},{"issue":"6","key":"ref_7","first-page":"783","article-title":"Central venous catheter-induced endocarditis: human correlate of the animal experimental model of endocarditis","volume":"1984","author":"Tsao, M.M.; Katz, D.","unstructured":"Tsao, M.M. & Katz, D. Central venous catheter-induced endocarditis: human correlate of the animal experimental model of endocarditis. Rev Inf Dis 1984, 6: 783-770.","journal-title":"Rev Inf Dis"},{"issue":"111","key":"ref_8","first-page":"128","article-title":"Right-sided valvular endocarditis: aetiology, diagnosis and an approach to therapy","volume":"1986","author":"Robbins, M.J.; Soeiro, R.; Frishman, W.H.; Strom, J.A.","unstructured":"Robbins, M.J., Soeiro, R., Frishman, W.H. & Strom, J.A. Right-sided valvular endocarditis: aetiology, diagnosis and an approach to therapy. Am Heart J 1986, 111: 128-135.","journal-title":"Am Heart J"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0002-9343(86)90204-4","article-title":"Fatal bacterial endocarditis as a complication ofpermanent indwelling catheters","volume":"81","author":"Power, J.; Wing, E.J.; Talamo, T.; Stanko, R.","year":"1986","unstructured":"Power, J., Wing, E.J., Talamo, T. & Stanko, R. Fatal bacterial endocarditis as a complication ofpermanent indwelling catheters. Am J Med 1986, 81: 166-168.","journal-title":"Am J Med"},{"key":"ref_10","first-page":"120","article-title":"Cardiac complications of total parenteral nutrition: the role of twodimensional echocardiography in diagnosis","volume":"71","author":"Chamsi-Pasha, H.; Stokes, M.; Irving, M.","year":"1989","unstructured":"Chamsi-Pasha, H., Stokes, M. & Irving, M. Cardiac complications of total parenteral nutrition: the role of twodimensional echocardiography in diagnosis. Ann R Coll Surg Engl 1989, 71: 120-123.","journal-title":"Ann R Coll Surg Engl"},{"issue":"10","key":"ref_11","first-page":"542","article-title":"Total parenteral nutrition catheter sepsis: impact of the team approach","volume":"1986","author":"Faubion, W.C.; Wesley, J.R.; Khalidi, N.; Silva, J.","unstructured":"Faubion, W.C., Wesley, J.R., Khalidi, N. & Silva, J. Total parenteral nutrition catheter sepsis: impact of the team approach. JPEN J Parenter Enteral Nutr 1986, 10: 542-645.","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJM197111252852203","article-title":"Fungal septicaemia in patients receiving parenteral alimentation","volume":"285","author":"Cury, C.R.; Quie, P.G.","year":"1971","unstructured":"Cury, C.R. & Quie, P.G. Fungal septicaemia in patients receiving parenteral alimentation. N Engi J Med 1971, 285: 1221-1224.","journal-title":"N Engi J Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/jama.1970.03170160044008","article-title":"Candida sepsis complicating parenteral feeding","volume":"212","author":"Ashcraft, K.W.; Leape, L.L.","year":"1970","unstructured":"Ashcraft, K.W. & Leape, L.L. Candida sepsis complicating parenteral feeding. JAMA 1970, 212: 454-456.","journal-title":"JAMA"},{"key":"ref_14","first-page":"43","article-title":"Candida lung abscesses complicating parenteral nutrition","volume":"1988","author":"O'Driscoll, B.R.C.; Cooke, R.D.P.; Mamtora, H.; Bernstein, A.","unstructured":"O'Driscoll, B.R.C., Cooke, R.D.P., Mamtora, H. & Bernstein, A. Candida lung abscesses complicating parenteral nutrition. Thorax 1988, 43: 418-419.","journal-title":"Thorax"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/infdis\/143.5.655","article-title":"Haematogenous candida endophthalmitis in patients receiving parenteral hyperalimentation fluids","volume":"143","author":"Henderson, D.K.; Edwards, J.E.; Montgomerie, J.Z.","year":"1981","unstructured":"Henderson, D.K., Edwards, J.E. & Montgomerie, J.Z. Haematogenous candida endophthalmitis in patients receiving parenteral hyperalimentation fluids. J Infect Dis 1981, 143: 655-661.","journal-title":"J Infect Dis"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0022-3468(84)80363-2","article-title":"Complications ofsuperior versus inferior vena cava occlusion in infants receiving total parenteral nutrition","volume":"19","author":"Mulvihill, S.J.; Fenkaisrud, E.W.","year":"1984","unstructured":"Mulvihill, S.J. & Fenkaisrud, E.W. Complications ofsuperior versus inferior vena cava occlusion in infants receiving total parenteral nutrition. J Pediatr Surg 1984, 19: 752-757.","journal-title":"J Pediatr Surg"},{"issue":"98","key":"ref_17","first-page":"469","article-title":"Echocardiographic diagnosis of intracardiac thrombi complicating total parenteral nutrition","volume":"1981","author":"Mahony, L.; Snider, A.R.; Silverman, N.H.","unstructured":"Mahony, L., Snider, A.R. & Silverman, N.H. Echocardiographic diagnosis of intracardiac thrombi complicating total parenteral nutrition. J Pediatr 1981, 98: 469.","journal-title":"J Pediatr"},{"key":"ref_18","article-title":"Two dimensional echocardiography in the evaluation of right heart disease: five cases in paediatric patients","author":"Riggs, T.; Paul, M.H.; DeLeon, S.; Ilbawi, M.","unstructured":"Riggs, T., Paul, M.H., DeLeon, S. & Ilbawi, M. Two dimensional echocardiography in the evaluation of right heart disease: five cases in paediatric patients. Am J Cardiol","journal-title":"Am J Cardiol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0022-3476(86)80849-6","article-title":"Intracardiac thrombi complicating central total parenteral nutrition: resolution without surgery or thrombolysis","volume":"108","author":"Mendoza, G.J.B.; Soto, A.; Brown, E.G.; Dolgin, S.E.; Steinfeld, L.; Sweet, A.Y.","year":"1986","unstructured":"Mendoza, G.J.B., Soto, A., Brown, E.G., Dolgin, S.E., Steinfeld, L. & Sweet, A.Y. Intracardiac thrombi complicating central total parenteral nutrition: resolution without surgery or thrombolysis. J Pediatr 1986, 108: 610-613.","journal-title":"J Pediatr"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/802\/629\/50074352\/postgradmedj-68-629.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/802\/629\/50074352\/postgradmedj-68-629.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T15:59:43Z","timestamp":1682611183000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/68\/802\/629\/7062422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,8,1]]},"references-count":19,"journal-issue":{"issue":"802","published-online":{"date-parts":[[1992,8,1]]},"published-print":{"date-parts":[[1992,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.68.802.629","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1992,8]]},"published":{"date-parts":[[1992,8,1]]}}}