{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T16:45:06Z","timestamp":1682613906007},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"803","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We have studied by the in situ hybridization method the presence of Epstein-Barr virus (EBV) DNA genome in lymph node tissues from 11 patients with persistent generalized lymphadenopathy. Using a biotinylated EBV DNA probe, we demonstrated EBV nucleic acid in scattered germinal centre cells in eight of the 11 cases. Our results suggest that EBV is not a determinant factor in the pathogenesis of this lymphadenopathy, but support its possible implication in B cell malignant transformation in cases of AIDS-associated lymphoma.<\/jats:p>","DOI":"10.1136\/pgmj.68.803.739","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"739-741","source":"Crossref","is-referenced-by-count":2,"title":["<i>In situ<\/i> demonstration of Epstein-Barr virus in intravenous drug abusers with generalized lymphadenopathy"],"prefix":"10.1093","volume":"68","author":[{"given":"F","family":"Mampaso","sequence":"first","affiliation":[{"name":"Departments of Pathology, Hospital Ramon y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Bellas","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Hospital Ramon y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Molina","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Hospital Ramon y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Quereda","sequence":"additional","affiliation":[{"name":"Departments of Microbiology, Hospital Ramon y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Bricio","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Hospital Ramon y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Buzon","sequence":"additional","affiliation":[{"name":"Departments of Microbiology, Hospital Ramon y Cajal , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1001\/jama.1983.03340100040026","article-title":"Lymphadenopathies in homosexual men. Relationship with the acquired immune deficiency syndrome","volume":"250","author":"loachin, H.L.; Lerner, C.W.; Tapper, M.L.","year":"1983","unstructured":"loachin, H.L., Lerner, C.W. & Tapper, M.L. Lymphadenopathies in homosexual men. Relationship with the acquired immune deficiency syndrome. JAMA 1983, 250: 1306-1309.","journal-title":"JAMA"},{"issue":"133","key":"ref_2","first-page":"498","article-title":"Expression of HIV in lymph node cells ofLAS patients. Immunohistology, in situ hybridization and identification of target cells","volume":"1988","author":"Baroni, C.D.; Pezzella, F.; Pezzella, M.","unstructured":"Baroni, C.D., Pezzella, F., Pezzella, M. et al. Expression of HIV in lymph node cells ofLAS patients. Immunohistology, in situ hybridization and identification of target cells. Am J Pathol 1988, 133: 498-506.","journal-title":"Am J Pathol"},{"issue":"72","key":"ref_3","first-page":"667","article-title":"Frequent c-myc oncogene activation and infrequent presence of Epstein-Barr virus genome in AIDSassociated lymphoma","volume":"1988","author":"Subar, M.; Neri, A.; Inghirami, G.; Knowles, D.; Dalla Favera, R.","unstructured":"Subar, M., Neri, A., Inghirami, G., Knowles, D. & Dalla Favera, R. Frequent c-myc oncogene activation and infrequent presence of Epstein-Barr virus genome in AIDSassociated lymphoma. Blood 1988, 72: 667-671.","journal-title":"Blood"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0042-6822(83)90460-9","article-title":"Detection of viral genomes in cultured cells and paraffin-embedded tissue sections using biotin-labeled hybridization probes","volume":"126","author":"Brigati, D.J.; Myerson, D.; Leary, J.J.","year":"1983","unstructured":"Brigati, D.J., Myerson, D., Leary, J.J. et al. Detection of viral genomes in cultured cells and paraffin-embedded tissue sections using biotin-labeled hybridization probes. Virology 1983, 126: 32-50.","journal-title":"Virology"},{"issue":"2","key":"ref_5","first-page":"319","article-title":"A distinctive follicular hyperplasia in the acquired immune deficiency syndrome (AIDS) and the AIDS-related complex. A prelymphomatous state for B cell lymphomas?","volume":"1984","author":"Meyer, P.R.; Yanagihara, E.T.; Parker, J.W.; Lukes, R.J.","unstructured":"Meyer, P.R., Yanagihara, E.T., Parker, J.W. & Lukes, R.J. A distinctive follicular hyperplasia in the acquired immune deficiency syndrome (AIDS) and the AIDS-related complex. A prelymphomatous state for B cell lymphomas? Hematol Oncol 1984, 2: 319-347.","journal-title":"Hematol Oncol"},{"key":"ref_6","first-page":"7824","article-title":"Human c-myc onc gene is located on the region","volume-title":"of chromosome 8 that is translocated in Burkitt's lymphoma. Proc Natl Acad Sci","volume":"79","author":"Dalla Favera, R.; Bregni, M.; Erikson, J.; Patterson, D.; Gallo, R.C.; Croce, C.M.","year":"1982","unstructured":"Dalla Favera, R., Bregni, M., Erikson, J., Patterson, D., Gallo, R.C. & Croce, C.M. Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt's lymphoma. Proc Natl Acad Sci USA 1982, 79: 7824-7827."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/ajcp\/92.6.729","article-title":"Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) antigens and genome in lymph nodes of HIV-positive patients affected by persistent generalized lymphadenopathy (PGL)","volume":"92","author":"Uccini, S.; Monardo, F.; Vitolo, D.","year":"1989","unstructured":"Uccini, S., Monardo, F., Vitolo, D. et al. Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) antigens and genome in lymph nodes of HIV-positive patients affected by persistent generalized lymphadenopathy (PGL). Am J Clin Pathol 1989, 92: 729-735.","journal-title":"Am J Clin Pathol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1084\/jem.164.6.2049","article-title":"Multiple monoclonal B cell expansions and c-myc oncogene rearrangements in acquired immune deficiency syndrome-related lymphoproliferative disorders","volume":"164","author":"Pellicci, P.G.; Knowles, D.M.; Arin, Z.A.","year":"1986","unstructured":"Pellicci, P.G., Knowles, D.M., Arin, Z.A. et al. Multiple monoclonal B cell expansions and c-myc oncogene rearrangements in acquired immune deficiency syndrome-related lymphoproliferative disorders. J Exp Med 1986, 164: 2049-2076.","journal-title":"J Exp Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/803\/739\/50074606\/postgradmedj-68-739.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/803\/739\/50074606\/postgradmedj-68-739.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T16:00:46Z","timestamp":1682611246000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/68\/803\/739\/7062517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9,1]]},"references-count":8,"journal-issue":{"issue":"803","published-online":{"date-parts":[[1992,9,1]]},"published-print":{"date-parts":[[1992,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.68.803.739","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1992,9]]},"published":{"date-parts":[[1992,9,1]]}}}