{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:40:51Z","timestamp":1752550851075},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"803","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Hypercalcaemia occurs in up to 80% of patients with adult T-cell leukaemia-lymphoma (ATLL) associated with human T-cell leukaemia virus-1 infection. Elevated serum levels of 1,25-dihydroxycholecalciferol, implicated in the pathogenesis of hypercalcaemia in lymphoma, and of parathyroid hormone-related protein (PTHrP), which is associated with hypercalcaemia of several solid malignancies, were demonstrated in a patient with ATLL hypercalcaemia. Treatment with bisphosphonates reduced the serum calcium but had no significant effect on the serum PTHrP levels. This case supports recent in vitro evidence for enhanced PTHrP expression in ATLL tumour cells and suggests that more than one tumour cell product may be involved in the pathogenesis of ATLL hypercalcaemia.<\/jats:p>","DOI":"10.1136\/pgmj.68.803.753","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"753-755","source":"Crossref","is-referenced-by-count":19,"title":["Elevated serum parathyroid hormone related protein and 1,25-dihydroxycholecalciferol in hypercalcaemia associated with adult T-cell leukaemia-lymphoma"],"prefix":"10.1093","volume":"68","author":[{"given":"S R D","family":"Johnston","sequence":"first","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital , Du Cane Road, London W12 0HS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Hammond","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital , Du Cane Road, London W12 0HS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0140-6736(82)92200-0","article-title":"Adult T-cell leukaemia-lymphoma in blacks from the West Indies","volume":"1","author":"Catovsky, D.; Greaves, M.F.; Rose, M.","year":"1982","unstructured":"Catovsky, D., Greaves, M.F., Rose, M. et al. Adult T-cell leukaemia-lymphoma in blacks from the West Indies. Lancet 1982, 1: 639-643.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/pgmj.66.779.757","article-title":"Intermittent hypercalcaemia and vitamin D sensitivity in Hodgkin's disease","volume":"66","author":"Karmali, R.; Barker, S.; Hewson, M.","year":"1990","unstructured":"Karmali, R., Barker, S., Hewson, M. et al. Intermittent hypercalcaemia and vitamin D sensitivity in Hodgkin's disease. Postgrad Med J 1990, 66: 757-760.","journal-title":"Postgrad Med J"},{"issue":"1","key":"ref_3","first-page":"7","article-title":"Hypercalcaemia associated withincreased serum calcitriol levels in three patients with lymphoma","volume":"100","author":"Breslau, N.A.; McGuire, J.L.; Zerwekh, J.E.","year":"1984","unstructured":"Breslau, N.A., McGuire, J.L., Zerwekh, J.E. et al. Hypercalcaemia associated withincreased serum calcitriol levels in three patients with lymphoma. 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