{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:33:00Z","timestamp":1779395580220,"version":"3.53.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"804","license":[{"start":{"date-parts":[[1992,10,1]],"date-time":"1992-10-01T00:00:00Z","timestamp":717897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>In a randomized prospective trial of prophylactic antibiotics in at-risk abdominal surgery, one dose of intravenous Augmentin (amoxycillin 250 mg and clavulanic acid 125 mg) on induction has been compared with three 8 hourly doses in 900 patients. Wound infection rates which included minor and delayed infections were very similar in those given one dose: 48\/449 (10.7%) compared with those given three doses: 49\/451 (10.9%) 95% confidence limits - 4.25% + 3.9%.<\/jats:p>\n               <jats:p>There were more septic and sepsis-related deaths in those patients given one dose (14 deaths) than in those given three doses (7 deaths) P &amp;gt; 0.1 95% CL - 0.4% + 3.0%. However, there were more very elderly patients in the one dose group: 64% of the deaths were aged over 80 and all but one had an emergency operation. There was no difference in the other outcome measures studied which included non-fatal deep sepsis, length of postoperative hospital stay, duration of postoperative fever or the use of antibiotics for postoperative infection.<\/jats:p>\n               <jats:p>One dose of a suitable intravenous antibiotic gives prophylaxis against wound infection in at-risk abdominal surgery which is at least as effective as multiple doses. However, there may be a risk of overwhelming systemic sepsis in very elderly patients having emergency surgery.<\/jats:p>","DOI":"10.1136\/pgmj.68.804.811","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"811-816","source":"Crossref","is-referenced-by-count":14,"title":["A randomized trial of one versus three doses of Augmentin as wound prophylaxis in at-risk abdominal surgery"],"prefix":"10.1093","volume":"68","author":[{"given":"Tom","family":"Bates","sequence":"first","affiliation":[{"name":"The William Harvey Hospital , Ashford, Kent TN24 0LZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan V","family":"Roberts","sequence":"additional","affiliation":[{"name":"The William Harvey Hospital , Ashford, Kent TN24 0LZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Smith","sequence":"additional","affiliation":[{"name":"The William Harvey Hospital , Ashford, Kent TN24 0LZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl A","family":"German","sequence":"additional","affiliation":[{"name":"The William Harvey Hospital , Ashford, Kent TN24 0LZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1992,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1136\/bmj.1.6071.1254","article-title":"Prophylactic use of Cephazolin against wound sepsis after cholecystectomy","volume":"1","author":"Strachan, C.J.L.; Black, J.; Powis, S.J.A.","year":"1977","unstructured":"Strachan, C.J.L., Black, J., Powis, S.J.A. et al. Prophylactic use of Cephazolin against wound sepsis after cholecystectomy. Br Med J 1977, 1: 1254-1256.","journal-title":"Br Med J"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/bjs.1800660820","article-title":"Wound sepsis following gastro-intestinal surgery: a comparison of topical and two dose systemic cephradine","volume":"66","author":"Finch, D.R.A.; Taylor, L.; Morris, P.J.","year":"1979","unstructured":"Finch, D.R.A., Taylor, L. & Morris, P.J. Wound sepsis following gastro-intestinal surgery: a comparison of topical and two dose systemic cephradine. Br J Surg 1979, 66: 580-582.","journal-title":"Br J Surg"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/bjs.1800670206","article-title":"Single and multiple dose cotrimoxazole and metronidazole in colorectal surgery","volume":"67","author":"Higgins, A.F.; Lewis, A.; Noone, P.; Hole, M.L.","year":"1980","unstructured":"Higgins, A.F, Lewis, A., Noone, P. & Hole, M.L. Single and multiple dose cotrimoxazole and metronidazole in colorectal surgery. Br J Surg 1980, 67: 90-92.","journal-title":"Br J Surg"},{"issue":"57","key":"ref_4","first-page":"363","article-title":"The evaluation of cefuroxin in the prevention of post-operative infection","volume":"1981","author":"Croton, R.S.; Sykes, D.; Treanor, J.","unstructured":"Croton, R.S., Sykes, D., Treanor, J. et al. The evaluation of cefuroxin in the prevention of post-operative infection. Postgrad Med J 1981, 57: 363-365.","journal-title":"Postgrad Med J"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1445-2197.1981.tb04963.x","article-title":"Prevention of wound infection in elective colorectal resections by pre-operative cephazolin with and without metronidazole","volume":"51","author":"McDermott, F.T.; Polglase, A.L.; Johnson, W.R.; Hughes, E.S.R.","year":"1981","unstructured":"McDermott, F.T., Polglase, A.L., Johnson, W.R. & Hughes, E.S.R. 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