{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T16:45:14Z","timestamp":1682613914483},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"805","license":[{"start":{"date-parts":[[1992,11,1]],"date-time":"1992-11-01T00:00:00Z","timestamp":720576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>There is experimental evidence that a portion of follicle-stimulating hormone (FSH) secretion is independent of hypothalamic influences. A 29 year old woman with familial pure gonadal dysgenesis developed myelodysplastic syndrome. Endocrine investigations showed discrepancy between serum FSH and luteinizing hormone (LH) levels. FSH levels remained elevated while LH levels decreased. The FSH to LH ratio was 10 (normal 2-2.5). The fall in LH is likely to be due to factor(s) involved directly and specifically in LH synthesis and release. Exogenous LH releasing hormone administration as well as hormonal replacement treatment increased LH levels. The FSH to LH ratio decreased to 7. This case supports the hypothesis of differential regulation of FSH and LH, and that FSH secretion is at least partly autonomous.<\/jats:p>","DOI":"10.1136\/pgmj.68.805.925","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:01:03Z","timestamp":1230584463000},"page":"925-927","source":"Crossref","is-referenced-by-count":1,"title":["Further evidence for differential regulation of follicle-stimulating hormone (FSH) and luteinizing hormone (LH): increased FSH and decreased LH levels in a patient with familial pure gonadal dysgenesis"],"prefix":"10.1093","volume":"68","author":[{"given":"V","family":"Popovic","sequence":"first","affiliation":[{"name":"Institute of Endocrinology, University Clinical Center, School of Medicine , Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Micic","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, University Clinical Center, School of Medicine , Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Damjanovic","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, University Clinical Center, School of Medicine , Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L J","family":"Calovic","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , Titograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Rolovic","sequence":"additional","affiliation":[{"name":"Institute of Haematology, University Clinical Center , Belgrade, Yugoslavia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mijovic","sequence":"additional","affiliation":[{"name":"Institute of Haematology, University Clinical Center , Belgrade, Yugoslavia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Petakov","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, University Clinical Center, School of Medicine , Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Manojlovic","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, University Clinical Center, School of Medicine , Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Micic","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, University Clinical Center, School of Medicine , Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1210\/endo-128-4-1731","article-title":"Hypersecretion of follicle-stimulating hormone (FSH) after ovariectomy of hypophysectomized, pituitarygrafted rats: implications for local regulatory control of FSH","volume":"128","author":"DePaolo, L.","year":"1991","unstructured":"DePaolo, L. Hypersecretion of follicle-stimulating hormone (FSH) after ovariectomy of hypophysectomized, pituitarygrafted rats: implications for local regulatory control of FSH. Endocrinology 1991, 128: 1731-1740.","journal-title":"Endocrinology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00293782","article-title":"Pure gonadal dysgenesis (type XX). Report on a family with four affected sibs","volume":"37","author":"Nazareth, H.R.; Farah, L.; Cuniha, A.","year":"1977","unstructured":"Nazareth, H.R., Farah, L., Cuniha, A. et al. Pure gonadal dysgenesis (type XX). Report on a family with four affected sibs. Hum Genet 1977, 37: 117-120.","journal-title":"Hum Genet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"Proposals for the classification of the myelodysplastic syndromes","volume":"51","author":"Bennet, J.M.; Catovsky, D.; Daniel, M.; Flandrin, G.; Galton, D.; Gralnick, H.; Sultan, C.","year":"1982","unstructured":"Bennet, J.M., Catovsky, D., Daniel, M., Flandrin, G., Galton, D., Gralnick, H. & Sultan, C. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982, 51: 189-199.","journal-title":"Br J Haematol"},{"issue":"63","key":"ref_4","first-page":"143","article-title":"Bioand immunoreactive luteinizing hormone responses to low doses of gonadotropin-releasing hormone (GnRH): dose response curves in GnRH-deficient men","volume":"1986","author":"Spratt, D.I.; Finkelstein, J.S.; Badger, T.M.; Butler, J.P.; Crowly, W.F.","unstructured":"Spratt, D.I., Finkelstein, J.S., Badger, T.M., Butler, J.P. & Crowly, W.F. Bioand immunoreactive luteinizing hormone responses to low doses of gonadotropin-releasing hormone (GnRH): dose response curves in GnRH-deficient men. J Clin Endocrinol Metab 1986, 63: 143-150.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1210\/jcem-72-3-660","article-title":"Estrogen regulates the gonadotrophin-releasing hormone-stimulated secretion of biologically active luteinizing hormone","volume":"72","author":"Urban, R.; Veldhius, J.; Dufau, M.","year":"1991","unstructured":"Urban, R., Veldhius, J. & Dufau, M. Estrogen regulates the gonadotrophin-releasing hormone-stimulated secretion of biologically active luteinizing hormone. J Clin Endocrinol Metab 1991, 72: 660-668.","journal-title":"J Clin Endocrinol Metab"},{"issue":"122","key":"ref_6","first-page":"2211","article-title":"Simultaneous measurement of luteinizing hormone (LH)-releasing hormone, LH, and follicle-stimulating hormone release in intact and short term castrate rats","volume":"1988","author":"Levine, E.; Duffy, M.","unstructured":"Levine, E. & Duffy, M. Simultaneous measurement of luteinizing hormone (LH)-releasing hormone, LH, and follicle-stimulating hormone release in intact and short term castrate rats. Endocrinology 1988, 122: 2211-2221.","journal-title":"Endocrinology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1210\/endo-91-3-643","article-title":"Acute and chronic effects of hypothalamic lesions on the release of FSH, LH and prolactin in intact and castrated rats","volume":"91","author":"Bishop, W.; Fawcett, C.P.; Krulich, L.; McCann, S.M.","year":"1972","unstructured":"Bishop, W., Fawcett, C.P., Krulich, L. & McCann, S.M. Acute and chronic effects of hypothalamic lesions on the release of FSH, LH and prolactin in intact and castrated rats. Endocrinology 1972, 91: 643-656.","journal-title":"Endocrinology"},{"issue":"234","key":"ref_8","first-page":"205","article-title":"Inhibin-mediated feedback control follicle-stimulating hormone secretion in female rats","volume":"1986","author":"Rivier, C.; Vale, W.","unstructured":"Rivier, C. & Vale, W. Inhibin-mediated feedback control follicle-stimulating hormone secretion in female rats. Science 1986, 234: 205-208.","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1210\/endo-127-2-798","article-title":"Gonadal regulation of gonadotropin subunit gene expression: evidence for regulation of follicle-stimulating hormone-beta messenger ribonucleic acid by nonsteroidal hormones in female rats","volume":"127","author":"Dalkin, A.; Haisenlender, D.; Ortolano, G.; Suhr, A.; Marshall, J.","year":"1990","unstructured":"Dalkin, A., Haisenlender, D., Ortolano, G., Suhr, A. & Marshall, J. Gonadal regulation of gonadotropin subunit gene expression: evidence for regulation of follicle-stimulating hormone-beta messenger ribonucleic acid by nonsteroidal hormones in female rats. Endocrinology 1990, 127: 798-924.","journal-title":"Endocrinology"},{"issue":"38","key":"ref_10","first-page":"2363","article-title":"Top concentrations of dimorphin-like immunoreactivity in fractions of rat anterior pituitary cells enriched in gonadotrops","volume":"1986","author":"Knepel, W.; Schwaninger, M.; Helm, C.; Kiessel, L.","unstructured":"Knepel, W., Schwaninger, M., Helm, C. & Kiessel, L. Top concentrations of dimorphin-like immunoreactivity in fractions of rat anterior pituitary cells enriched in gonadotrops. Life Sci 1986, 38: 2363-2367.","journal-title":"Life Sci"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/805\/925\/50074600\/postgradmedj-68-925.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/68\/805\/925\/50074600\/postgradmedj-68-925.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T16:11:01Z","timestamp":1682611861000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/68\/805\/925\/7062595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11,1]]},"references-count":10,"journal-issue":{"issue":"805","published-online":{"date-parts":[[1992,11,1]]},"published-print":{"date-parts":[[1992,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.68.805.925","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1992,11]]},"published":{"date-parts":[[1992,11,1]]}}}