{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:16:39Z","timestamp":1759990599195},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"810","license":[{"start":{"date-parts":[[1993,4,1]],"date-time":"1993-04-01T00:00:00Z","timestamp":733622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>To compare the efficacy of imprint cytology, histology and CLO-test (for biopsy urease) in detecting Helicobacter pylori infection, antral biopsies were taken from 239 patients undergoing upper gastrointestinal endoscopy. Both imprint cytology and histology showed the presence of H. pylori in 215 (90%) patients. The sensitivity and specificity of imprint cytology vis-\u00e0-vis histology was noted to be 100%. The CLO-test was performed in 165 patients and was positive in 130 (79%) patients. The sensitivity and specificity of the CLO-test were 89% and 95%, respectively. The median time required for the CLO-test to become positive and for imprint was 60 minutes for each. The sensitivity of the CLO-test was reduced further in patients receiving colloidal bismuth subcitrate. Of the 27 patients receiving the drug the sensitivity of the CLO-test was only 9% after 4 weeks of therapy. However, the specificity was 100%. The sensitivity and specificity of imprint cytology were unaffected by the antimicrobial therapy and after 4 weeks of treatment were still 100%.<\/jats:p>\n               <jats:p>It is concluded that the CLO-test has a lower sensitivity and specificity for diagnosing H. pylori infection compared to imprint cytology, which had a sensitivity and specificity equal to that of histology. Imprint cytology may be prepared as an adjunct to histology in patients in whom antral biopsies are taken as it offers a relatively quick diagnosis of H. pylori infection, is considerably cheaper than the CLO-test and does not require additional biopsy material.<\/jats:p>","DOI":"10.1136\/pgmj.69.810.291","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"291-295","source":"Crossref","is-referenced-by-count":15,"title":["Imprint cytology--a cheap, rapid and effective method for diagnosing <i>Helicobacter pylori<\/i>"],"prefix":"10.1093","volume":"69","author":[{"given":"S P","family":"Misra","sequence":"first","affiliation":[{"name":"Departments of Gastroenterology and Pathology, M.L.N. Medical College , Allahabad - 211 001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology and Pathology, M.L.N. Medical College , Allahabad - 211 001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vatsala","family":"Misra","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology and Pathology, M.L.N. Medical College , Allahabad - 211 001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S C","family":"Gupta","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology and Pathology, M.L.N. Medical College , Allahabad - 211 001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1993,4,1]]},"reference":[{"key":"ref_1","first-page":"69","article-title":"Detection of Campylobacter pylori by the biopsy urease test","volume-title":"Campylobacterpyloriand Gastroduodenal Disease","author":"McNulty, C.A.M.","year":"1989","unstructured":"McNulty, C.A.M. Detection of Campylobacter pylori by the biopsy urease test. In: Rathbone, B.J. & Heatley, R.V. (eds) Campylobacterpyloriand Gastroduodenal Disease. Blackwell, Oxford, 1989, pp. 69-73."},{"issue":"64","key":"ref_2","first-page":"935","article-title":"Rapid urease test provides specific identification of Campylobacter pylori in antral mucosal biopsies","volume":"1988","author":"Szeto, M.-L.; Pounder, R.E.; Hamilton-Dutoit, Sl; DhilIon, A.P.","unstructured":"Szeto, M.-L., Pounder, R.E., Hamilton-Dutoit, S.l. & DhilIon, A.P. 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Lancet 1987, i: 1174-1177.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1136\/gut.31.11.1237","article-title":"Evaluation of 13C-urea breath test in the detection of Helicobacter pylori and in monitoring the effect of tripotassium dicitratobismuthate in non-ulcer dyspepsia","volume":"31","author":"Dill, S.; Payne-James, J.J.; Misiewicz, J.J.","year":"1990","unstructured":"Dill, S., Payne-James, J.J., Misiewicz, J.J. et al. Evaluation of 13C-urea breath test in the detection of Helicobacter pylori and in monitoring the effect of tripotassium dicitratobismuthate in non-ulcer dyspepsia. Gut 1990, 31: 1237-1241.","journal-title":"Gut"},{"key":"ref_12","first-page":"74","article-title":"The serology of campylobacter pylori infections","volume-title":"Campylobacterpyloriand Gastroduodenal Disease","author":"Newell, D.G.; Stacey, A.R.","year":"1989","unstructured":"Newell, D.G. & Stacey, A.R. The serology of campylobacter pylori infections. In: Rathbone, B.J. & Heatley, R.V. (eds) Campylobacterpyloriand Gastroduodenal Disease. Blackwell, Oxford, 1989, pp. 74-82."},{"key":"ref_13","first-page":"467","article-title":"Diagnostic efficiency of an ultrarapid endoscopy room test for Helicobacter pylori","volume-title":"Gut","volume":"32","author":"Thillainayagam, A.V.; Arvind, A.S.; Cook, R.S.; Harrison, I.G.; Tabaqchali, S.; Farthing, M.J.G.","year":"1991","unstructured":"Thillainayagam, A.V., Arvind, A.S., Cook, R.S., Harrison, I.G., Tabaqchali, S. & Farthing, M.J.G. Diagnostic efficiency of an ultrarapid endoscopy room test for Helicobacter pylori. 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(English Abstract).","journal-title":"Gastroenterol Clin Biol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/00365528909091323","article-title":"Rapid diagnosis of Campylobacter pylori by brush cytology","volume":"167","author":"Gad, A.","year":"1989","unstructured":"Gad, A. Rapid diagnosis of Campylobacter pylori by brush cytology. Scand J Gastroenterol 1989, 24 (Suppl 167): 101-103.","journal-title":"Scand J Gastroenterol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1136\/jcp.39.11.1279-a","article-title":"Simplified techniques for identifying campylobacter pyloridis","volume":"39","author":"Grag, S.F.; Wyatt, J.I.; Rathbone, B.J.","year":"1986","unstructured":"Grag, S.F., Wyatt, J.I. & Rathbone, B.J. Simplified techniques for identifying campylobacter pyloridis. J Clin Pathol 1986, 39: 1279-1280.","journal-title":"J Clin Pathol"},{"issue":"83","key":"ref_18","first-page":"1035","article-title":"The prevalence of Campylobacterpyloriin 1,447 patients at endoscopy","volume":"1988","author":"McNulty, C.A.M.; Dent, J.C.; Uff, J.G.","unstructured":"McNulty, C.A.M., Dent, J.C., Uff, J.G. et al. The prevalence of Campylobacterpyloriin 1,447 patients at endoscopy. Am J Gastroenterol 1988, 83: 1035.","journal-title":"Am J Gastroenterol"},{"key":"ref_19","first-page":"297","article-title":"Campylobacter pylori gastritis. II. Distribution of bacteria and associated inflammation in the gastroduodenal environment","volume":"82","author":"Hazell, S.L.; Hennessy, W.B.; Borody, T.J.","year":"1987","unstructured":"Hazell, S.L., Hennessy, W.B., Borody, T.J. et al. Campylobacter pylori gastritis. II. Distribution of bacteria and associated inflammation in the gastroduodenal environment. Am J Gastroenterol 1987, 82: 297-301.","journal-title":"Am J Gastroenterol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/jcp.39.5.531","article-title":"Campylobacter-like organisms and reflux gastritis","volume":"39","author":"O'Connor, H.J.; Wyatt, J.I.; Dixon, M.F.; Axon, A.T.R.","year":"1986","unstructured":"O'Connor, H.J., Wyatt, J.I., Dixon, M.F. & Axon, A.T.R. Campylobacter-like organisms and reflux gastritis. J Clin Pathol 1986, 39: 531-534.","journal-title":"J Clin Pathol"},{"issue":"41","key":"ref_21","first-page":"1093","article-title":"Campylobacterlike organisms and Candida in peptic ulcers and similar lesions of the upper gastrointestinal tract: a study of 247 cases","volume":"1988","author":"Kalogeropoulros, N.K.; Whitehead, R.","unstructured":"Kalogeropoulros, N.K. & Whitehead, R. Campylobacterlike organisms and Candida in peptic ulcers and similar lesions of the upper gastrointestinal tract: a study of 247 cases. J Clin Pathol 1988, 41: 1093-1098.","journal-title":"J Clin Pathol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/jcp.42.4.348","article-title":"Gastric metaplasia and Campylobacter pylori infection of duodenum in patients with chronic renal failure","volume":"42","author":"Shousha, S.; Keen, C.; Parkins, R.A.","year":"1989","unstructured":"Shousha, S., Keen, C. & Parkins, R.A. Gastric metaplasia and Campylobacter pylori infection of duodenum in patients with chronic renal failure. J Clin Pathol 1989, 42: 348-351.","journal-title":"J Clin Pathol"},{"key":"ref_23","first-page":"1245","article-title":"'Eradication' of Campylobacter pylori: are we being mislead?","volume":"ii:","author":"Weil, J.; Bell, G.D.; Jones, P.H.; Grant, P.; Trowell, J.E.; Harrison, G.","year":"1988","unstructured":"Weil, J., Bell, G.D., Jones, P.H., Grant, P., Trowell, J.E. & Harrison, G. 'Eradication' of Campylobacter pylori: are we being mislead? Lancet 1988, ii: 1245.","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/00365528909091730","article-title":"The reliability ofurease test, histology and culture in the diagnosis of campylobacter pylori infection","volume":"160","author":"Deltenre, M.; Glupczynski, Y.; de Perez, C.","year":"1989","unstructured":"Deltenre, M., Glupczynski, Y., de Perez, C. et al. The reliability ofurease test, histology and culture in the diagnosis of campylobacter pylori infection. Scand J Gastroenterol 1989, 24 (Suppl 160): 19-24.","journal-title":"Scand J Gastroenterol"},{"issue":"14","key":"ref_25","first-page":"907","article-title":"Histological improvement of active gastritis in patients treated with De-Nol","volume":"1984","author":"Marshall, B.J.; Hislop, I.; Glancy, R.; Armstrong, J.","unstructured":"Marshall, B.J., Hislop, I., Glancy, R. & Armstrong, J. Histological improvement of active gastritis in patients treated with De-Nol. 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Br Med J 1986, 293: 645-649.","journal-title":"Br Med J"},{"key":"ref_28","first-page":"33","article-title":"Campylobacter pyloridis associated chronic active antral gastritis. A prospective study of its prevalence and the effect","volume-title":"of antibacterial and antiulcer treatment. Gastroenterology 1988","volume":"94","author":"Ramos, E.A.J.; Langenberg, W.; Houthoff, H.J.; Zanen, H.C.; Tytgat, G.N.J.","unstructured":"Ramos, E.A.J., Langenberg, W., Houthoff, H.J., Zanen, H.C. & Tytgat, G.N.J. Campylobacter pyloridis associated chronic active antral gastritis. A prospective study of its prevalence and the effect of antibacterial and antiulcer treatment. 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Gut 1989, 30: 1206-1212.","journal-title":"Gut"},{"key":"ref_30","first-page":"368","article-title":"Clearance of Campylobacter pylori and reduced duodenal ulcer relapse with bismuth and tinidazole compared to cimetidine","volume":"Goteberg,","author":"Goodwin, C.S.; Marshall, B.J.; Warren, J.R.; Blackbourn, S.; Blinco, W.E.D.","unstructured":"Goodwin, C.S., Marshall, B.J., Warren, J.R., Blackbourn, S. & Blinco, W.E.D. Clearance of Campylobacter pylori and reduced duodenal ulcer relapse with bismuth and tinidazole compared to cimetidine. In: Kaijser, B. & Falsen, E. (eds) Campylobacter IV, University of Goteberg, Goteberg, pp. 368-369."},{"issue":"23","key":"ref_31","first-page":"101","article-title":"Monotherapy or polychemotherapy in the treatment ofcampylobacter pylorirelated gastroduodenal disease","volume":"1988","author":"Borsch, G.; Mal, U.; Muller, K.M.","unstructured":"Borsch, G., Mal, U. & Muller, K.M. Monotherapy or polychemotherapy in the treatment ofcampylobacter pylorirelated gastroduodenal disease. Scand J Gastroenterol 1988, 23 (Suppl 142): 101-106.","journal-title":"Scand J Gastroenterol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/69\/810\/291\/50072871\/postgradmedj-69-291.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/69\/810\/291\/50072871\/postgradmedj-69-291.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T12:44:26Z","timestamp":1682599466000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/69\/810\/291\/7062742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4,1]]},"references-count":31,"journal-issue":{"issue":"810","published-online":{"date-parts":[[1993,4,1]]},"published-print":{"date-parts":[[1993,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.69.810.291","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1993,4]]},"published":{"date-parts":[[1993,4,1]]}}}