{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T11:50:12Z","timestamp":1703418612680},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"811","license":[{"start":{"date-parts":[[1993,5,1]],"date-time":"1993-05-01T00:00:00Z","timestamp":736214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Both high resolution (10 MHz) ultrasound and 201-thallium\/99m-technetium subtraction scanning (Tl\/Tc) were carried out preoperatively in 25 patients with primary hyperparathyroidism.<\/jats:p>\n               <jats:p>Operative findings were the standard against which these two imaging methodologies were compared. Tl\/Tc scanning showed a sensitivity of 42% and a specificity of 97%. By comparison, sensitivity of ultrasound was 38% and specificity 89%. Both techniques were positive together in nine instances and correctly localized the parathyroid adenoma in eight of these. In 44% of cases, however, both methods together failed to localize any abnormal parathyroid tissue.<\/jats:p>\n               <jats:p>The ability of these modalities to localize abnormal parathyroid tissue correctly tended to vary with gland size. Where both ultrasound and Tl\/Tc scans were negative, median gland size was smaller at 170 mg (range 50-2,500 mg), compared with where Tl\/Tc scanning was correct (750 mg, 150-6,820 mg; P &amp;lt; 0.03), ultrasound was correct (960 mg, 100-6,820 mg; P &amp;lt; 0.03) and both techniques together were correct (980 mg, 600-6,820 mg; P = 0.002).<\/jats:p>\n               <jats:p>These results suggest that neither Tl\/Tc scanning or ultrasound has sufficient sensitivity or specificity to be used routinely in the preoperative evaluation of patients with primary hyperparathyroidism.<\/jats:p>","DOI":"10.1136\/pgmj.69.811.376","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"376-380","source":"Crossref","is-referenced-by-count":6,"title":["A comparison of 10 MHz ultrasound and 201-thallium\/99m-technetium subtraction scanning in primary hyperparathyroidism"],"prefix":"10.1093","volume":"69","author":[{"given":"S J","family":"Gallacher","sequence":"first","affiliation":[{"name":"University Departments of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Kelly","sequence":"additional","affiliation":[{"name":"University Departments of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Shand","sequence":"additional","affiliation":[{"name":"Department of Radiology, Stobhill Hospital , Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F C","family":"Logue","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Glasgow Royal Infirmary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Cooke","sequence":"additional","affiliation":[{"name":"University Departments of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I T","family":"Boyle","sequence":"additional","affiliation":[{"name":"University Departments of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"McKillop","sequence":"additional","affiliation":[{"name":"University Departments of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1993,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.7326\/0003-4819-114-7-593","article-title":"Diagnosis and management ofasymptomatic primary hyperparathyroidism: Consensus Development Conference statement","volume":"114","author":"Consensus Development Conference Panel","year":"1991","unstructured":"Consensus Development Conference Panel. Diagnosis and management ofasymptomatic primary hyperparathyroidism: Consensus Development Conference statement. Ann Intern Med 1991, 114: 593-597.","journal-title":"Ann Intern Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.7326\/0003-4819-107-1-64","article-title":"Parathyroid imaging","volume":"107","author":"Winzelberg, G.G.","year":"1987","unstructured":"Winzelberg, G.G. Parathyroid imaging. Ann Intern Med 1987, 107: 64-70.","journal-title":"Ann Intern Med"},{"issue":"156","key":"ref_3","first-page":"323","article-title":"Preoperative localisation of parathyroid adenomas","volume":"1988","author":"Attie, J.N.; Khan, A.; Rumancik, W.M.Miskowitz; W., G.; Hirsch, M.A.; Herman, P.G.","unstructured":"Attie, J.N., Khan, A., Rumancik, W.M. Miskowitz, G.W., Hirsch, M.A. & Herman, P.G. Preoperative localisation of parathyroid adenomas. Am J Surg 1988, 156: 323-326.","journal-title":"Am J Surg"},{"key":"ref_4","first-page":"186","article-title":"Localisation of parathyroid adenomas by","author":"Young, A.E.; Gaunt, J.I.; Croft, D.N.; Collins, R.E.C.; Wells, C.P.; Coakley, A.J.","year":"1983","unstructured":"Young, A.E., Gaunt, J.I., Croft, D.N., Collins, R.E.C., Wells, C.P. & Coakley, A.J. Localisation of parathyroid adenomas by thallium 201 and technetium 99m subtraction scanning. Br Med J 1983, 186: 136-138.","journal-title":"Br Med J; and technetium 99m subtraction scanning"},{"key":"ref_5","first-page":"539","volume":"139","author":"Reading, C.C.; Charboneau, J.W.; James, E.M.","year":"1982","unstructured":"Reading, C.C., Charboneau, J.W., James, E.M. et al. High resolution parathyroid sonography. Am J Roentgenol 1982, 139: 539-546.","journal-title":"et al. High resolution parathyroid sonography. Am J Roentgenol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1148\/radiology.148.1.6856852","article-title":"Parathyroid scanning by computed tomography","volume":"148","author":"Stark, D.D.; Moss, A.A.; Gooding, G.A.W.; Clark, O.H.","year":"1983","unstructured":"Stark, D.D., Moss, A.A., Gooding, G.A.W. & Clark, O.H. Parathyroid scanning by computed tomography. Radiology 1983, 148: 297-299.","journal-title":"Radiology"},{"key":"ref_7","first-page":"96","article-title":"Magnetic resonance imaging of the thyroid, thymus and parathyroid glands","volume":"1984","author":"Stark, D.D.; Clark, O.H.; A, Moss A.","unstructured":"Stark, D.D., Clark, O.H. & Moss. A.A. Magnetic resonance imaging of the thyroid, thymus and parathyroid glands. 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A two-site immunoradiometric assay for PTH(1-84) using N and C terminal specific monoclonal antibodies. Ann Clin Biochem 1991, 28: 160-166.","journal-title":"Ann Clin Biochem"},{"key":"ref_10","first-page":"545","article-title":"Successful localisation of parathyroid adenomata by","volume":"9","author":"Fogelman, I.; McKillop, J.H.; Bessent, R.G.; Boyle, I.T.; Gray, H.W.; Gunn, I.; Hutchison, J.S.F.","year":"1984","unstructured":"Fogelman, I., McKillop, J.H., Bessent, R.G., Boyle, I.T., Gray, H.W., Gunn, I. & Hutchison, J.S.F. Successful localisation of parathyroid adenomata by thallium 201 and technetium 99m subtraction scintigraphy. Description of an improved technique. Eur J Nucl Med 1984, 9: 545-547.","journal-title":"Eur J Nucl Med; and technetium 99m subtraction scintigraphy. Description of an improved technique"},{"key":"ref_11","first-page":"887","article-title":"Parathyroid imaging","volume":"32","author":"Goris, M.L.; Basso, L.V.; Keeling, C.","year":"1991","unstructured":"Goris, M.L., Basso, L.V. & Keeling, C. Parathyroid imaging. J Nucl Med 1991, 32: 887-889.","journal-title":"J Nucl Med"},{"key":"ref_12","first-page":"639","article-title":"Prospective comparison of radionuclide, computed tomographic, sonographic and magnetic resonance localisation of parathyroid tumours","volume":"106","author":"Krubsack, A.J.; Wilson, S.D.; Lawson, T.L.","year":"1989","unstructured":"Krubsack, A.J., Wilson, S.D., Lawson, T.L. et al. Prospective comparison of radionuclide, computed tomographic, sonographic and magnetic resonance localisation of parathyroid tumours. Surgery 1989, 106: 639-646.","journal-title":"Surgery"},{"issue":"155","key":"ref_13","first-page":"231","article-title":"Parathyroid adenomas evaluated by 201TI\/99mTc pertechnetate scintigraphy and high resolution ultrasonography","volume":"1985","author":"Winzelberg, G.C.; Hydrovitz, J.D.; O'Hara, K.R.","unstructured":"Winzelberg, G.C., Hydrovitz, J.D., O'Hara, K.R. et al. Parathyroid adenomas evaluated by 201TI\/99mTc pertechnetate scintigraphy and high resolution ultrasonography. Radiology 1985, 155: 231-235.","journal-title":"Radiology"},{"issue":"161","key":"ref_14","first-page":"57","article-title":"Parathyroid imaging: comparison of double-tracer (TI-201, Tc-99m) scintigraphy and high resolution US","volume":"1986","author":"Gooding, G.A.W.; Okerlund, M.D.; Stark, D.D.; Clark, O.H.","unstructured":"Gooding, G.A.W., Okerlund, M.D., Stark, D.D. & Clark, O.H. Parathyroid imaging: comparison of double-tracer (TI-201, Tc-99m) scintigraphy and high resolution US. Radiology 1986, 161: 57-64.","journal-title":"Radiology"},{"key":"ref_15","first-page":"99","article-title":"The use of preoperative localization of adenomas of the parathyroid glands by thallium-technetium subtraction scintigraphy, high resolution ultrasonography and computed tomography","volume":"168","author":"Roses, D.F.; Sudarsky, L.A.; Sanger, J.","year":"1989","unstructured":"Roses, D.F., Sudarsky, L.A., Sanger, J. et al. The use of preoperative localization of adenomas of the parathyroid glands by thallium-technetium subtraction scintigraphy, high resolution ultrasonography and computed tomography. Surg Gynecol Obstet 1989, 168: 99-106.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_16","first-page":"438","article-title":"New perspectives in localising enlarged parathyroids by Technetium-Thallium subtraction scan","volume":"24","author":"Ferlin, G.; Borsato, M.; Camerani, M.; Conte, N.; Zotti, D.","year":"1983","unstructured":"Ferlin, G., Borsato, M., Camerani, M., Conte, N. & Zotti, D. New perspectives in localising enlarged parathyroids by Technetium-Thallium subtraction scan. J Nucl Med 1983, 24: 438-441.","journal-title":"J Nucl Med"},{"issue":"22","key":"ref_17","first-page":"511","article-title":"How reliable is Thallium-201\/Technetium-99m subtraction scintigraphy in localising parathyroid adenomata?","volume":"1986","author":"Gunn, I.G.; McKillop, J.H.; McBride, D.","unstructured":"Gunn, I.G., McKillop, J.H., McBride, D. et al. How reliable is Thallium-201\/Technetium-99m subtraction scintigraphy in localising parathyroid adenomata? Nuklear Medizin 1986, 22 (Suppl): 511-513.","journal-title":"Nuklear Medizin"},{"key":"ref_18","first-page":"27","article-title":"Limits to parathyroid imaging with thallium-201 confirmed by tissue uptake and phantom studies","volume":"1986","author":"Gimlette, T.M.D.; Brownless, S.M.; Taylor, W.H.; Shields, R.; Simkin, E.P.","unstructured":"Gimlette, T.M.D., Brownless, S.M., Taylor, W.H., Shields, R. & Simkin, E.P. Limits to parathyroid imaging with thallium-201 confirmed by tissue uptake and phantom studies. J Nucl Med 1986, 27: 1262-1265.","journal-title":"J Nucl Med"},{"key":"ref_19","first-page":"405","article-title":"Hypercalcaemiaa hospital survey","volume":"49","author":"Fisken, R.A.; Heath, D.A.; Bold, A.M.","year":"1980","unstructured":"Fisken, R.A., Heath, D.A. & Bold, A.M. Hypercalcaemiaa hospital survey. Q J Med 1980, NS 49: 405-418.","journal-title":"Q J Med"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1136\/bmj.287.6389.427-b","article-title":"Location ofparathyroid adenomas by 201T1 and 99mTc subtraction scanning","volume":"287","author":"Young, A.E.; Gaunt, J.I.; Croft, D.","year":"1983","unstructured":"Young, A.E., Gaunt, J.I. & Croft, D. Location ofparathyroid adenomas by 201T1 and 99mTc subtraction scanning. Br Med J 1983, 287: 427-428.","journal-title":"Br Med J"},{"key":"ref_21","first-page":"313","article-title":"Parathyroid imaging with technetium- 99msestamibi: preoperative localisation and tissue uptake studies","volume":"33","author":"O'Docherty, M.J.; Kettle, A.G.; Wells, P.; Collins, R.E.C.; Coakley, A.J.","year":"1992","unstructured":"O'Docherty, M.J., Kettle, A.G., Wells, P., Collins, R.E.C. & Coakley, A.J. Parathyroid imaging with technetium-99msestamibi: preoperative localisation and tissue uptake studies. J Nucl Med 1992, 33: 313-318.","journal-title":"J Nucl Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/69\/811\/376\/50072804\/postgradmedj-69-376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/69\/811\/376\/50072804\/postgradmedj-69-376.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T13:39:09Z","timestamp":1682602749000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/69\/811\/376\/7062916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5,1]]},"references-count":21,"journal-issue":{"issue":"811","published-online":{"date-parts":[[1993,5,1]]},"published-print":{"date-parts":[[1993,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.69.811.376","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1993,5]]},"published":{"date-parts":[[1993,5,1]]}}}