{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:08:20Z","timestamp":1764936500200},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"814","license":[{"start":{"date-parts":[[1993,8,1]],"date-time":"1993-08-01T00:00:00Z","timestamp":744163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Haemolytic-uraemic syndrome is characterized by thrombotic microangiopathy of the glomeruli and smaller arterial vessels of the kidney. Extrarenal thrombotic microangiopathy occurs, but ocular involvement is rarely demonstrated microscopically. We describe a 33 year old woman with a 3 week febrile episode and seropositivity for cytomegalovirus infection who developed acute renal failure, blindness and severe encephalopathy which was the cause of death. Thrombotic microangiopathy of retinal vessels may be more common than is expected from the literature. The exclusion of ocular structures in postmortem examinations explains the lack of anatomoclinical correlation.<\/jats:p>","DOI":"10.1136\/pgmj.69.814.653","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"653-655","source":"Crossref","is-referenced-by-count":16,"title":["Haemolytic-uraemic syndrome with thrombotic microangiopathy of the retina following cytomegalovirus infection: postmortem findings"],"prefix":"10.1093","volume":"69","author":[{"given":"Blanca","family":"Cat\u00f3n","sequence":"first","affiliation":[{"name":"Departments of Pathology and Internal Medicine, Hospital Txagorritxu , 01009 Vitoria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"D\u00edaz de Otazu","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Internal Medicine, Hospital Txagorritxu , 01009 Vitoria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikel","family":"Aldamiz-Echebarria","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Internal Medicine, Hospital Txagorritxu , 01009 Vitoria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amparo","family":"Viguri","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Internal Medicine, Hospital Txagorritxu , 01009 Vitoria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1993,8,1]]},"reference":[{"key":"ref_1","first-page":"292","article-title":"HUS and TTP: variable expression of a single entity","volume":"32","author":"Remuzzi, G.","year":"1987","unstructured":"Remuzzi, G. HUS and TTP: variable expression of a single entity. Kidney Int 1987, 32: 292-308."},{"key":"ref_2","first-page":"499","article-title":"Thrombotic microangiopathy","volume-title":"Renal Pathology in Biopsy","author":"Zollinger, H.U.; Mihatsch, M.J.","year":"1978","unstructured":"Zollinger, H.U. & Mihatsch, M.J. Thrombotic microangiopathy. In: Zollinger, H.U. & Mihatsch, M.J. (eds). Renal Pathology in Biopsy. Springer Verlag, Berlin, 1978, pp. 499-506."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0046-8177(88)80093-5","article-title":"The histopathology of the hemolytic uremic syndrome associated with verocytotoxin-producing Escherichia coli infections","volume":"19","author":"Richardson, S.E.; Karmali, M.A.; Becke, L.E.; Smith, C.R.","year":"1988","unstructured":"Richardson, S.E., Karmali, M.A., Becke, L.E. & Smith, C.R. The histopathology of the hemolytic uremic syndrome associated with verocytotoxin-producing Escherichia coli infections. Hum Pathol 1988, 19: 1102-1108.","journal-title":"Hum Pathol"},{"issue":"112","key":"ref_4","first-page":"594","article-title":"Ocular involvement in hemolytic-uremic syndrome","volume":"1988","author":"Siegler, R.L.; Brewer, E.D.; Swartz, M.","unstructured":"Siegler, R.L., Brewer, E.D. & Swartz, M. Ocular involvement in hemolytic-uremic syndrome. J Pediatr 1988, 112: 594-597.","journal-title":"J Pediatr"},{"issue":"8","key":"ref_5","first-page":"185","article-title":"Massive bilateral retinal vascular occlusion secondary to thrombocytopenic purpura","volume":"1988","author":"Gum, K.G.; Carter, K.D.; Vine, A.K.","unstructured":"Gum, K.G., Carter, K.D. & Vine, A.K. Massive bilateral retinal vascular occlusion secondary to thrombocytopenic purpura. 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Prognostic importance of vascular lesions in acute renal failure with microangiopathic hemolytic anemia (hemolytic-uremic syndrome): Clinicopathologic study in 20 adults. Kidney Int 1979, 15: 548-558.","journal-title":"Kidney Int"},{"issue":"105","key":"ref_8","first-page":"421","article-title":"Presumed thrombotic thrombocytopenic purpura associated with bilateral serous retinal detachments","volume":"1988","author":"Haemeter, W.","unstructured":"Haemeter, W. Presumed thrombotic thrombocytopenic purpura associated with bilateral serous retinal detachments. Am J Ophthalmol 1988, 105: 421-422.","journal-title":"Am J Ophthalmol"},{"key":"ref_9","first-page":"367","article-title":"The haemolytic uremic syndrome: a review","volume":"63","author":"Neild, G.","year":"1987","unstructured":"Neild, G. The haemolytic uremic syndrome: a review. Q J Med [New Series] 1987, 63: 367-376.","journal-title":"Q J Med [New Series]"},{"issue":"73","key":"ref_10","first-page":"505","article-title":"Hemolytic uremic syndrome: an analysis of the natural history and prognostic features","volume":"1984","author":"Loirat, C.; Sonsino, E.; Varga Moreno, A.","unstructured":"Loirat, C., Sonsino, E., Varga Moreno, A. et al. Hemolytic uremic syndrome: an analysis of the natural history and prognostic features. Acta Paediatr Scand 1984, 73: 505-514.","journal-title":"Acta Paediatr Scand"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ajh.2830250315","article-title":"Thrombotic thrombocytopenic purpura in human immunodeficiency virus (HIV)-seropositive homosexual man","volume":"25","author":"Jokela, J.; Flynn, T.; Henry, K.","year":"1987","unstructured":"Jokela, J., Flynn, T. & Henry, K. Thrombotic thrombocytopenic purpura in human immunodeficiency virus (HIV)-seropositive homosexual man. Am J Hematol 1987, 25: 341-345.","journal-title":"Am J Hematol"},{"key":"ref_12","first-page":"141","article-title":"Miscellaneous secondary thrombotic microangiopathy","volume":"24","author":"Kwaan, H.C.","year":"1987","unstructured":"Kwaan, H.C. Miscellaneous secondary thrombotic microangiopathy. Semin Hematol 1987, 24: 141-147.","journal-title":"Semin Hematol"},{"issue":"2","key":"ref_13","first-page":"580","article-title":"Pathogenesis of haemolytic uraemic syndrome","volume":"1988","author":"Rose, P.E.; Taylor, C.M.; Kavi, J.","unstructured":"Rose, P.E., Taylor, C.M. & Kavi, J. Pathogenesis of haemolytic uraemic syndrome. Lancet 1988, 2: 580.","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/archpedi.1980.02130210053014","article-title":"CNS manifestations of the hemolytic-uremic syndrome","volume":"134","author":"Bale, Jr, F.; Brasher, C.; Siegler, R.L.","year":"1980","unstructured":"Bale, F., Jr, Brasher, C. & Siegler, R.L. CNS manifestations of the hemolytic-uremic syndrome. Am J Dis Child 1980, 134: 869-872.","journal-title":"Am J Dis Child"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/ana.410190120","article-title":"Neurological involvement in hemolytic-uremic syndrome","volume":"19","author":"Sheth, K.J.; Swick, H.M.; Haworth, N.","year":"1986","unstructured":"Sheth, K.J., Swick, H.M. & Haworth, N. Neurological involvement in hemolytic-uremic syndrome. 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